Regioselective Cobalt-Catalyzed Addition of Sulfides to Unactivated Alkenes von Girijavallabhan, Vinay, Alvarez, Carmen, Njoroge, F. George

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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection von Njoroge, F. George, Chen, Kevin X, Shih, Neng-Yang, Piwinski, John J

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Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B von Zhang, Xiaoyan, Zhang, Nanjing, Chen, Guangming, Turpoff, Anthony, Ren, Hongyu, Takasugi, James, Morrill, Christie, Zhu, Jin, Li, Chunshi, Lennox, William, Paget, Steven, Liu, Yalei, Almstead, Neil, George Njoroge, F., Gu, Zhengxian, Komatsu, Takashi, Clausen, Valerie, Espiritu, Christine, Graci, Jason, Colacino, Joseph, Lahser, Fred, Risher, Nicole, Weetall, Marla, Nomeir, Amin, Karp, Gary M.

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Enantioselective Synthesis of 3,3-Difluoropyrrolidin-4-ol, a Valuable Building Block in Medicinal Chemistry von Si, Chong, Fales, Kevin R, Torrado, Alicia, Frimpong, Kwame, Kaoudi, Talbi, Vandeveer, Harold George, Njoroge, F. George

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Potent inhibitors of HCV-NS3 protease derived from boronic acids von Venkatraman, Srikanth, Wu, Wanli, Prongay, Andrew, Girijavallabhan, Viyyoor, George Njoroge, F.

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Structure–Activity Relationship (SAR) Optimization of 6‑(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting... von Zhang, Nanjing, Zhang, Xiaoyan, Zhu, Jin, Turpoff, Anthony, Chen, Guangming, Morrill, Christie, Huang, Song, Lennox, William, Kakarla, Ramesh, Liu, Ronggang, Li, Chunshi, Ren, Hongyu, Almstead, Neil, Venkatraman, Srikanth, Njoroge, F. George, Gu, Zhengxian, Clausen, Valerie, Graci, Jason, Jung, Stephen P., Zheng, Yingcong, Colacino, Joseph M., Lahser, Fred, Sheedy, Josephine, Mollin, Anna, Weetall, Marla, Nomeir, Amin, Karp, Gary M.

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A notable conversion of a thiolacetate to its corresponding sulfonyl chloride von Huang, Yuhua, Bennett, Frank, Verma, Vishal, George Njoroge, F., MacCoss, Malcolm

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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics von Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Heimark, Larry, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George

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II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides von Anilkumar, Gopinadhan N., Selyutin, Oleg, Rosenblum, Stuart B., Zeng, Qingbei, Jiang, Yueheng, Chan, Tin-Yau, Pu, Haiyan, Wang, Li, Bennett, Frank, Chen, Kevin X., Lesburg, Charles A., Duca, Jose, Gavalas, Stephen, Huang, Yuhua, Pinto, Patrick, Sannigrahi, Mousumi, Velazquez, Francisco, Venkatraman, Srikanth, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Huang, H.-C., Shih, Neng-Yang, George Njoroge, F., Kozlowski, Joseph A.

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Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical spe... von Bogen, Stéphane L., Arasappan, Ashok, Velazquez, Francisco, Blackman, Melissa, Huelgas, Regina, Pan, Weidong, Siegel, Elise, Nair, Latha G., Venkatraman, Srikanth, Guo, Zhuyan, Doll, Ronald, Shih, Neng-Yang, George Njoroge, F.

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Novel substituted pyrimidines as HCV replication (replicase) inhibitors von Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Shih, Neng-Yang, Piwinski, John J., Li, Cheng, Feld, Boris, Huang, Hsueh-Cheng, Tong, Xiao, George Njoroge, F., Arasappan, Ashok

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Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors von Girijavallabhan, Vinay M., Alvarez, Carmen, Bennett, Frank, Chen, Lei, Gavalas, Stephen, Huang, Yuhua, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Bansal, Namita, Clark, Jeremy L., Fowler, Anita T., Kezar, Hollis S., Valiyaveettil, Jacob, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George, Arasappan, Ashok

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Potent aza-peptide derived inhibitors of HCV NS3 protease von Venkatraman, Srikanth, Wu, Wanli, Shih, Neng-Yang, George Njoroge, F.

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5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors von Arasappan, Ashok, Bennett, Frank, Girijavallabhan, Vinay, Huang, Yuhua, Huelgas, Regina, Alvarez, Carmen, Chen, Lei, Gavalas, Stephen, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George

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P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile von Nair, Latha G., Sannigrahi, Mousumi, Bogen, Stephane, Pinto, Patrick, Chen, Kevin X., Prongay, Andrew, Tong, Xiao, Cheng, K.-C., Girijavallabhan, Viyyoor, George Njoroge, F.

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Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors von Tong, Xiao, Guo, Zhuyan, Wright-Minogue, Jacquelyn, Xia, Ellen, Prongay, Andrew, Madison, Vincent, Qiu, Ping, Venkatraman, Srikanth, Velazquez, Francisco, Njoroge, F. George, Malcolm, Bruce A.

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Characterization of resistance mutations against HCV ketoamide protease inhibitors von Tong, Xiao, Bogen, Stephane, Chase, Robert, Girijavallabhan, V., Guo, Zhuyan, Njoroge, F. George, Prongay, Andrew, Saksena, Anil, Skelton, Angela, Xia, Ellen, Ralston, Robert

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Discovery of N‑(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)‑3-hydroxypyrrolidin-1-yl]­thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate... von Fales, Kevin R., Njoroge, F. George, Brooks, Harold B., Thibodeaux, Stefan, Torrado, Alicia, Si, Chong, Toth, James L., Mc Cowan, Jefferson R., Roth, Kenneth D., Thrasher, Kenneth J., Frimpong, Kwame, Lee, Matthew R., Dally, Robert D., Shepherd, Timothy A., Durham, Timothy B., Margolis, Brandon J., Wu, Zhipei, Wang, Yong, Atwell, Shane, Wang, Jing, Hui, Yu-Hua, Meier, Timothy I., Konicek, Susan A., Geeganage, Sandaruwan

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Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors von Bennett, Frank, Kezar, Hollis S., Girijavallabhan, Vinay, Huang, Yuhua, Huelgas, Regina, Rossman, Randall, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, George Njoroge, F., Arasappan, Ashok

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An efficient synthesis of 3,4-dihydropyridone via a tandem olefin isomerization–ring-closing metathesis reaction von Si, Chong, Fales, Kevin R., Boyer, Robert D., George Njoroge, F.

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