ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets von Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W

Volltext

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo von Wendt, Michael D, Shen, Wang, Kunzer, Aaron, McClellan, William J, Bruncko, Milan, Oost, Thorsten K, Ding, Hong, Joseph, Mary K, Zhang, Haichao, Nimmer, Paul M, Ng, Shi-Chung, Shoemaker, Alexander R, Petros, Andrew M, Oleksijew, Anatol, Marsh, Kennan, Bauch, Joy, Oltersdorf, Tilman, Belli, Barbara A, Martineau, Darlene, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

Volltext

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL von Bruncko, Milan, Oost, Thorsten K, Belli, Barbara A, Ding, Hong, Joseph, Mary K, Kunzer, Aaron, Martineau, Darlene, McClellan, William J, Mitten, Michael, Ng, Shi-Chung, Nimmer, Paul M, Oltersdorf, Tilman, Park, Cheol-Min, Petros, Andrew M, Shoemaker, Alexander R, Song, Xiaohong, Wang, Xilu, Wendt, Michael D, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

Volltext

An inhibitor of Bcl-2 family proteins induces regression of solid tumours von Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao

Volltext

Design, Synthesis, and Computational Studies of Inhibitors of Bcl-XL von Park, Cheol-Min, Oie, Tetsuro, Petros, Andrew M, Zhang, Haichao, Nimmer, Paul M, Henry, Rodger F, Elmore, Steven W

Volltext

Design, Synthesis, and Computational Studies of Inhibitors of Bcl-X L von Park, Cheol-Min, Oie, Tetsuro, Petros, Andrew M., Zhang, Haichao, Nimmer, Paul M., Henry, Rodger F., Elmore, Steven W.

Volltext

A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children von Brousseau, David C., Scott, J. Paul, Badaki-Makun, Oluwakemi, Darbari, Deepika S., Chumpitazi, Corrie E., Airewele, Gladstone E., Ellison, Angela M., Smith-Whitley, Kim, Mahajan, Prashant, Sarnaik, Sharada A., Casper, T. Charles, Cook, Lawrence J., Dean, J. Michael, Leonard, Julie, Hulbert, Monica L., Powell, Elizabeth C., Liem, Robert I., Hickey, Robert, Krishnamurti, Lakshmanan, Hillery, Cheryl A., Nimmer, Mark, Panepinto, Julie A.

Volltext

Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity von Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

Volltext

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity von Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

Volltext

Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR von Petros, Andrew M., Huth, Jeffrey R., Oost, Thorsten, Park, Cheol-Min, Ding, Hong, Wang, Xilu, Zhang, Haichao, Nimmer, Paul, Mendoza, Renaldo, Sun, Chaohong, Mack, Jamey, Walter, Karl, Dorwin, Sarah, Gramling, Emily, Ladror, Uri, Rosenberg, Saul H., Elmore, Steven W., Fesik, Stephen W., Hajduk, Philip J.

Volltext

Higher Dose of Opioids in the Emergency Department and Earlier Initiation of Oral Opioids after Hospitalization Are Associated with Shorter Length of Stay in Children with Sickle C... von Brandow, Amanda M, Nimmer, Mark, Simmons, Timothy, Casper, T Charles, Cook, Larry J, Scott, J. Paul, Panepinto, Julie A., Brousseau, David C.

Volltext

Impact of emergency department care on outcomes of acute pain events in children with sickle cell disease von Brandow, Amanda M., Nimmer, Mark, Simmons, Timothy, Charles Casper, T., Cook, Lawrence J., Chumpitazi, Corrie E., Paul Scott, J., Panepinto, Julie A., Brousseau, David C.

Volltext

Glycan-Mediated, Ligand-Controlled Click Chemistry for Drug-Target Identification von Stöckmann, Henning, Marin, Violeta L., Nimmer, Paul, Balut, Corina M., Davidson, Donald J., Richardson, Paul L., Vasudevan, Anil

Volltext

A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo von SHOEMAKER, Alex R, OLEKSIJEW, Anatol, MARSH, Kennan, MCCLELLAN, William, NELLANS, Hugh, NG, Shichung, NIMMER, Paul, O'CONNOR, Jacqueline M, OLTERSDORF, Tilman, WEIGUO QING, WANG SHEN, STAVROPOULOS, Jason, BAUCH, Joy, TAHIR, Stephen K, BAOLE WANG, WARNER, Robert, HAICHAO ZHANG, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, BELLI, Barbara A, BORRE, Tony, BRUNCKO, Milan, DECKWIRTH, Thomas, FROST, David J, JARVIS, Ken, JOSEPH, Mary K

Volltext

Development of a high-throughput fluorescence polarization assay for Bcl-x(L) von Zhang, Haichao, Nimmer, Paul, Rosenberg, Saul H, Ng, Shi-Chung, Joseph, Mary

Volltext

Correction to Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity von Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

Volltext

Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity von Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M., Park, Chang H., Boghaert, Erwin R., Catron, Nathaniel D., Chen, Jun, Colman, Peter M., Czabotar, Peter E., Deshayes, Kurt, Fairbrother, Wayne J., Flygare, John A., Hymowitz, Sarah G., Jin, Sha, Judge, Russell A., Koehler, Michael F. T., Kovar, Peter J., Lessene, Guillaume, Mitten, Michael J., Ndubaku, Chudi O., Nimmer, Paul, Purkey, Hans E., Oleksijew, Anatol, Phillips, Darren C., Sleebs, Brad E., Smith, Brian J., Smith, Morey L., Tahir, Stephen K., Watson, Keith G., Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H., Tse, Chris, Leverson, Joel D., Elmore, Steven W., Souers, Andrew J.

Volltext

The Bcl-2 Family Protein Inhibitor, ABT-263, Promotes Apoptotic-Like Response in Isolated Platelets von Tse, Chris, Zhang, Haichao, Chen, Jun, Fryer, Ryan M., Nelson, Richard, Nimmer, Paul, Reinhart, Glenn A., Smith, Morey L., Tahir, Stephen K., Rosenberg, Saul H., Elmore, Steven W.

Volltext

The Bcl-2 Family Inhibitor ABT-263 Shows Significant Anti-Tumor Efficacy in Models of B Cell Non-Hodgkin's Lymphoma von Shoemaker, Alex R., Mitten, Michael J., Oleksijew, Anatol, O'Connor, Jacqeuline M., Wang, Baole, Ackler, Scott, Joseph, Mary, Zhang, Haichao, Nimmer, Paul, Xiao, Yu, Tse, Christin, Frost, David J., Fesik, Stephen W., Rosenberg, Saul H., Elmore, Steven W.

Volltext

Recommendations on Responsibility for Design and Construction of Precast Concrete Structures von HANSON, JOHN M., BRECHER, E. FRED, GUTT, TED J., Mack, Paul D., NIMMER, MILO J., RATHS, CHARLES H., VOSS, JAMES R., WILDEN, HELMUTH

Volltext