Temsirolimus combined with sorafenib in hepatocellular carcinoma: a phase I dose-finding trial with pharmacokinetic and biomarker correlates von Kelley, R.K., Nimeiri, H.S., Munster, P.N., Vergo, M.T., Huang, Y., Li, C.-M., Hwang, J., Mulcahy, M.F., Yeh, B.M., Kuhn, P., Luttgen, M.S., Grabowsky, J.A., Stucky-Marshall, L., Korn, W.M., Ko, A.H., Bergsland, E.K., Benson, A.B., Venook, A.P.

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Pan-tumor landscape of fibroblast growth factor receptor 1-4 genomic alterations von Murugesan, K., Necchi, A., Burn, T.C., Gjoerup, O., Greenstein, R., Krook, M., López, J.A., Montesion, M., Nimeiri, H., Parikh, A.R., Roychowdhury, S., Schwemmers, S., Silverman, I.M., Vogel, A.

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Phase 2 Trial of Preoperative Radiation With Concurrent Capecitabine, Oxaliplatin, and Bevacizumab Followed by Surgery and Postoperative 5-FU, Leucovorin, Oxaliplatin (FOLFOX), and... von Prabhu, R.S, Feng, Y, Landry, J.C, Cohen, S.J, Staley, C.A, Whittington, R, Sigurdson, E.R, Nimeiri, H, Verma, U, Benson, A.B

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113P The association of changes in circulating tumor fraction and in actionable variant allele frequencies with clinical outcomes in real world diverse cohort of advanced patients... von Iams, W., Guittar, J., Dugan, A.J., Mitra, A., Ben-Shachar, R., Nimeiri, H.

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79P Comprehensive genomic profiling provides patients access to novel matched therapies in a diverse real-world cohort of advanced lung cancer patients von Patel, J.D., Nadhamuni, K., Mitra, A., Carty, M., Nimeiri, H., Klein, I., Pelossof, R.

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Phase II Study of Preoperative Radiation With Concurrent Capecitabine, Oxaliplatin, and Bevacizumab Followed by Surgery and Postoperative 5-FU, Leucovorin, Oxaliplatin (FOLFOX), an... von Landry, J.C, Feng, Y, Cohen, S.J, Staley, C, Whittington, R, Sigurdson, E.R, Nimeiri, H, Verma, U, Prabhu, R.S, Benson, A.B

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185P Real-world data analysis of genomic profiling-matched targeted therapy outcomes in patients with fusion-positive NSCLC von Patel, J., Ben-Shachar, R., Nadhamuni, K., Carty, M., Pelossof, R., Klein, I., Nimeiri, H., Aggarwal, C., Gentzler, R.D.

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EP.06F.06 Concurrent DNA and RNA NGS Testing to Characterize Rare Fusions in Advanced NSCLC Patients von Feliciano, J.L., Gai, L., Rivers, Z., Hockenberry, A.J., Nimeiri, H., Beauchamp, K.A., Ben-Shachar, R., Guinney, J., Patel, J.

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182P ALK fusion detection by RNA next-generation sequencing (NGS) compared to DNA in a large, real-world non-small cell lung cancer (NSCLC) dataset von Iams, W., Ben-Shachar, R., Gai, L., Beauchamp, K., Sharma, N., Islam, S., Guinney, J., Nimeiri, H., Gentzler, R.D., Cohen, E.

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203P Genomic characterization of sporadic MET amplified non-small cell lung cancer (NSCLC) and association with real-world outcomes von Gentzler, R.D., Sharma, N., Mitra, A., Ben-Shachar, R., Stein, M., Guinney, J., Nimeiri, H., Iams, W., Aggarwal, C., Patel, J.

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EP.07D.05 Molecular Testing Care Gap Analysis of EGFR Mutation for Early-Stage NSCLC Patients in Community Practices von Dow, J., Zimmerman, N., Monzon, S., Zhao, W., Barrett, A., Erese, V., Gurbatri, C., Cohen, E., ScottoDiVetta, C., Huerga, I., Nimeiri, H., Owen, D.H., Patel, J.D.

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457P Circulating tumor DNA (ctDNA) from patients (pts) with advanced colorectal cancer (CRC) is enriched for EGFR extracellular domain (ECD) mutations von Tejpar, S., Tukachinsky, H., Zhang, L., Schrock, A.B., Decker, B., Pavlick, D.C., Venstrom, J., Nimeiri, H., Oxnard, G.

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100P Co-mutational landscape of key fibroblast growth factor receptor (FGFR) alterations in intra-hepatic cholangiocarcinoma (iCCA), bladder cancer (BC) and glioma von Necchi, A., Murugesan, K., Burn, T., Gjoerup, O., Greenstein, R., López, J.A., Montesion, M., Nimeiri, H., Parikh, A.R., Roychowdhury, S., Schwemmers, S., Silverman, I.M., Vogel, A.

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477P Utilisation and predictors of genomic testing prior to first-line (1L) therapy in patients (pts) with metastatic colorectal cancer (mCRC) von Lenz, H.J., Weberpals, J., Cremolini, C., Grothey, A., Leutgeb, B., Mahrus, S., Nimeiri, H., Reyes-Rivera, I., Seligmann, J., Tabernero, J., Tejpar, S., Yoshino, T., Stintzing, S.

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1739O - A phase I study evaluating rovalpituzumab tesirine (ROVA-T) in frontline treatment of patients (pts) with extensive stage small cell lung cancer (ES-SCLC) von Hann, C., Burns, T., Dowlati, A., Morgensztern, D., Koch, M., Chang, Y.-W., Komarnitsky, P., Ludwig, C., Nimeiri, H., Camidge, D.R.

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1739OA phase I study evaluating rovalpituzumab tesirine (ROVA-T) in frontline treatment of patients (pts) with extensive stage small cell lung cancer (ES-SCLC) von Hann, C, Burns, T, Dowlati, A, Morgensztern, D, Koch, M, Chang, Y-W, Komarnitsky, P, Ludwig, C, Nimeiri, H, Camidge, D R

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A phase I study evaluating rovalpituzumab tesirine (ROVA-T) in frontline treatment of patients (pts) with extensive stage small cell lung cancer (ES-SCLC) von Hann, C., Burns, T., Dowlati, A., Morgensztern, D., Koch, M., Chang, Y.-W., Komarnitsky, P., Ludwig, C., Nimeiri, H., Camidge, D.R.

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Challenges with linezolid therapy and reversible pancytopenia von Nimeiri, H S, Nemiary, D S

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A phase I trial of the combination of temsirolimus (TEM) and sorafenib (SOR) in advanced hepatocellular carcinoma (HCC) von Kelley, R. K., Nimeiri, H. S., Vergo, M. T., Bergsland, E. K., Ko, A. H., Munster, P. N., Reinert, A., Mulcahy, M. F., Benson, A. B., Venook, A. P.

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O-022A multi-institutional phase 2 study of single agent nivolumab in previously treated metastatic squamous cell carcinoma of the anal canal (SCCA) von Morris, V, Ciombor, K, Salem, M, Nimeiri, H, Iqbal, S, Singh, P, Polite, B, Deming, D, Chan, E, Wade, J, Bekaii-Saab, T, Wolff, R, Eng, C

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