Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer von Smyth, Lillian M., Batist, Gerald, Meric-Bernstam, Funda, Kabos, Peter, Spanggaard, Iben, Lluch, Ana, Jhaveri, Komal, Varga, Andrea, Wong, Andrea, Schram, Alison M., Ambrose, Helen, Carr, T. Hedley, de Bruin, Elza C., Salinas-Souza, Carolina, Foxley, Andrew, Hauser, Joana, Lindemann, Justin P. O., Maudsley, Rhiannon, McEwen, Robert, Moschetta, Michele, Nikolaou, Myria, Schiavon, Gaia, Razavi, Pedram, Banerji, Udai, Baselga, José, Hyman, David M., Chandarlapaty, Sarat

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A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diag... von Robertson, John F. R., Evans, Abigail, Henschen, Stephan, Kirwan, Cliona C., Jahan, Ali, Kenny, Laura M., Dixon, J. Michael, Schmid, Peter, Kothari, Ashutosh, Mohamed, Omar, Fasching, Peter A., Cheung, Kwok-Leung, Wuerstlein, Rachel, Carroll, Danielle, Klinowska, Teresa, Lindemann, Justin P. O., MacDonald, Alexander, Mather, Richard, Maudsley, Rhiannon, Moschetta, Michele, Nikolaou, Myria, Roudier, Martine P., Sarvotham, Tinnu, Schiavon, Gaia, Zhou, Diansong, Zhou, Li, Harbeck, Nadia

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A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors von Choudhury, Atish D, Higano, Celestia S, de Bono, Johann S, Cook, Natalie, Rathkopf, Dana E, Wisinski, Kari B, Martin-Liberal, Juan, Linch, Mark, Heath, Elisabeth I, Baird, Richard D, García-Carbacho, Javier, Quintela-Fandino, Miguel, Barry, Simon T, de Bruin, Elza C, Colebrook, Steve, Hawkins, George, Klinowska, Teresa, Maroj, Brijesh, Moorthy, Ganesh, Mortimer, Peter G, Moschetta, Michele, Nikolaou, Myria, Sainsbury, Liz, Shapiro, Geoffrey I, Siu, Lillian L, Hansen, Aaron R

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Abstract PD1-11: Mature survival update of the double-blind placebo-controlled randomised phase II PAKT trial of first-line capivasertib plus paclitaxel for metastatic triple-negat... von Schmid, Peter, Abraham, Jacinta, Chan, Stephen, Brunt, Adrian Murray, Nemsadze, Gia, Baird, Richard D, Park, Yeon Hee, Hall, Peter, Perren, Timothy, Stein, Robert C, Mangel, László, Ferrero, Jean-Marc, Phillips, Melissa, Conibear, John, Cortes, Javier, Foxley, Andrew, de Bruin, Elza, McEwen, Robert, Nikolaou, Myria, Stetson, Daniel, Dougherty, Brian, Prendergast, Aaron, McLaughlin-Callan, Max, Burgess, Matthew, Lawrence, Cheryl, Cartwright, Hayley, Mousa, Kelly, Turner, Nicholas, Wheatley, Duncan

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Successes and challenges faced by tissue collection during trials by oncology translational sciences von Roudier, Martine P, Rocher Ros, Vidalba, Hirst, Caroline, Nikolaou, Myria, Jones, Gemma N, Willis, Sophie E, Howat, William J, Barrett, J Carl, Harrington, Elizabeth

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Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers von Hudson, Kevin, Hancox, Urs J, Trigwell, Cath, McEwen, Robert, Polanska, Urszula M, Nikolaou, Myria, Morentin Gutierrez, Pablo, Avivar-Valderas, Alvaro, Delpuech, Oona, Dudley, Phillippa, Hanson, Lyndsey, Ellston, Rebecca, Jones, Alys, Cumberbatch, Marie, Cosulich, Sabina C, Ward, Lara, Cruzalegui, Francisco, Green, Stephen

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Abstract P6-04-01: A pre-surgical, window of opportunity study comparing the novel oral SERD AZD9496 with fulvestrant in patients with newly diagnosed ER+ HER2- primary breast canc... von Robertson, John FR, Evans, Abigail, Henschen, Stephan, Kirwan, Cliona, Jahan, Ali, Kenny, Laura, Dixon, J. Michael, Schmid, Peter, Kothari, Ashutosh, Mohamed, Omar, Fasching, Peter A, Cheung, Kwok-Leung, Wuerstlein, Rachel, Carroll, Danielle, Klinowska, Teresa, Lindemann, Justin PO, MacDonald, Alexander, Mather, Richard, Maudsley, Rhiannon, Moschetta, Michele, Nikolaou, Myria, Roudier, Martine P, Sarvotham, Tinnu, Schiavon, Gaia, Zhou, Diansong, Zhou, Li, Harbeck, Nadia

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Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC von Hayhow, Thomas G., Williamson, Beth, Lawson, Mandy, Cureton, Natalie, Braybrooke, Erin L., Campbell, Andrew, Carbajo, Rodrigo J., Cheraghchi-Bashi, Azadeh, Chiarparin, Elisabetta, Diène, Coura R., Fallan, Charlene, Fisher, David I., Goldberg, Frederick W., Hopcroft, Lorna, Hopcroft, Philip, Jackson, Anne, Kettle, Jason G., Klinowska, Teresa, Künzel, Ulrike, Lamont, Gillian, Lewis, Hilary J., Maglennon, Gareth, Martin, Scott, Gutierrez, Pablo Morentin, Morrow, Christopher J., Nikolaou, Myria, Nissink, J. Willem M., O’Shea, Patrick, Polanski, Radoslaw, Schade, Markus, Scott, James S., Smith, Aaron, Weber, Judith, Wilson, Joanne, Yang, Bin, Crafter, Claire

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Abstract P3-07-13: The next generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) is active against wild type and mutant estrogen receptor α von Morrow, Christopher, Carnevalli, Larissa, Baird, Richard D., Brier, Tim, Ciardullo, Carmela, Cureton, Natalie, Lawson, Mandy, McEwen, Robert, Nikolaou, Myria, Armstrong, Anne, Bermejo, Begoña, Calvo, Emiliano, Ciruelos, Eva, Garcia-Corbacho, Javier, Hamilton, Erika, Incorvati, Jason, Kabos, Peter, Oliveira, Mafalda, Patel, Manish R, Ruiz-Borregó, Manuel, Turner, Nicholas, Twelves, Chris, Vaklavas, Christos, Carroll, Danielle, Ching, Steven, Cvetesic, Nevena, DuPont, Michelle, Gibbons, Lisa, Mathewson, Alastair, Maudsley, Rhiannon, Gutierrez, Pablo Morentin, Reddy, Avinash, Rodriguez-Canales, Jaime, Ros, Susana, Sudhan, Dhivya, Sykes, Andy, Whitson, David, Klinowska, Teresa, Lindemann, Justin

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Abstract P3-07-13: The next generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) is active against wild type and mutant estrogen receptor α von Morrow, Christopher, Carnevalli, Larissa, Baird, Richard D, Brier, Tim, Ciardullo, Carmela, Cureton, Natalie, Lawson, Mandy, McEwen, Robert, Nikolaou, Myria, Armstrong, Anne, Bermejo, Begoña, Calvo, Emiliano, Ciruelos, Eva, Garcia-Corbacho, Javier, Hamilton, Erika, Incorvati, Jason, Kabos, Peter, Oliveira, Mafalda, Patel, Manish R, Ruiz-Borregó, Manuel, Turner, Nicholas, Twelves, Chris, Vaklavas, Christos, Carroll, Danielle, Ching, Steven, Cvetesic, Nevena, DuPont, Michelle, Gibbons, Lisa, Mathewson, Alastair, Maudsley, Rhiannon, Gutierrez, Pablo Morentin, Reddy, Avinash, Rodriguez-Canales, Jaime, Ros, Susana, Sudhan, Dhivya, Sykes, Andy, Whitson, David, Klinowska, Teresa, Lindemann, Justin

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A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors von Choudhury, Atish D, Higano, Celestia S, de Bono, Johann S, Cook, Natalie, Rathkopf, Dana E, Wisinski, Kari B, Martin-Liberal, Juan, Linch, Mark, Heath, Elisabeth I, Baird, Richard D, García-Carbacho, Javier, Quintela-Fandino, Miguel, Barry, Simon T, de Bruin, Elza C, Colebrook, Steve, Hawkins, George, Klinowska, Teresa, Maroj, Brijesh, Moorthy, Ganesh, Mortimer, Peter G, Moschetta, Michele, Nikolaou, Myria, Sainsbury, Liz, Shapiro, Geoffrey I, Siu, Lillian L, Hansen, Aaron R

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