Tracing the History of Goat Pastoralism: New Clues from Mitochondrial and Y Chromosome DNA in North Africa von Pereira, Filipe, Queirós, Sara, Gusmão, Leonor, Nijman, Isäac J., Cuppen, Edwin, Lenstra, Johannes A., Consortium, Econogene, Davis, Simon J.M., Nejmeddine, Fouad, Amorim, António

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Sambamba: fast processing of NGS alignment formats von Tarasov, Artem, Vilella, Albert J, Cuppen, Edwin, Nijman, Isaac J, Prins, Pjotr

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A systematic genome-wide analysis of zebrafish protein-coding gene function von Kettleborough, Ross N. W., Busch-Nentwich, Elisabeth M., Harvey, Steven A., Dooley, Christopher M., de Bruijn, Ewart, van Eeden, Freek, Sealy, Ian, White, Richard J., Herd, Colin, Nijman, Isaac J., Fényes, Fruzsina, Mehroke, Selina, Scahill, Catherine, Gibbons, Richard, Wali, Neha, Carruthers, Samantha, Hall, Amanda, Yen, Jennifer, Cuppen, Edwin, Stemple, Derek L.

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Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia von Massink, Maarten P.G., Créton, Marijn A., Spanevello, Francesca, Fennis, Willem M.M., Cune, Marco S., Savelberg, Sanne M.C., Nijman, Isaäc J., Maurice, Madelon M., van den Boogaard, Marie-José H., van Haaften, Gijs

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Effectiveness of whole-exome sequencing and costs of the traditional diagnostic trajectory in children with intellectual disability von Monroe, Glen R., Frederix, Gerardus W., Savelberg, Sanne M. C., de Vries, Tamar I., Duran, Karen J., van der Smagt, Jasper J., Terhal, Paulien A., van Hasselt, Peter M., Kroes, Hester Y., Verhoeven-Duif, Nanda M., Nijman, Isaäc J., Carbo, Ellen C., van Gassen, Koen L., Knoers, Nine V., Hövels, Anke M., van Haelst, Mieke M., Visser, Gepke, van Haaften, Gijs

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Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach von Mokry, Michal, Nijman, Isaäc J, van Dijken, Anja, Benjamins, Rene, Heidstra, Renze, Scheres, Ben, Cuppen, Edwin

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Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island von van Schaik, Willem, Top, Janetta, Riley, David R, Boekhorst, Jos, Vrijenhoek, Joyce E P, Schapendonk, Claudia M E, Hendrickx, Antoni P A, Nijman, Isaäc J, Bonten, Marc J M, Tettelin, Hervé, Willems, Rob J L

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Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples von Cuppen, Edwin, Nijman, Isaäc J, Mokry, Michal, van Boxtel, Ruben, Toonen, Pim, de Bruijn, Ewart

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Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease von Wiegerinck, Caroline L, Janecke, Andreas R, Schneeberger, Kerstin, Vogel, Georg F, van Haaften–Visser, Désirée Y, Escher, Johanna C, Adam, Rüdiger, Thöni, Cornelia E, Pfaller, Kristian, Jordan, Alexander J, Weis, Cleo–Aron, Nijman, Isaac J, Monroe, Glen R, van Hasselt, Peter M, Cutz, Ernest, Klumperman, Judith, Clevers, Hans, Nieuwenhuis, Edward E.S, Houwen, Roderick H.J, van Haaften, Gijs, Hess, Michael W, Huber, Lukas A, Stapelbroek, Janneke M, Müller, Thomas, Middendorp, Sabine

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Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells von Hatzis, Pantelis, van der Flier, Laurens G., van Driel, Marc A., Guryev, Victor, Nielsen, Fiona, Denissov, Sergei, Nijman, Isaäc J., Koster, Jan, Santo, Evan E., Welboren, Willem, Versteeg, Rogier, Cuppen, Edwin, van de Wetering, Marc, Clevers, Hans, Stunnenberg, Hendrik G.

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Pseudobudding: ruptured glands do not represent true tumor buds von Haddad, Tariq Sami, Dobbelsteen, Luuk, Öztürk, Sonay K, Geene, Robin, Nijman, Isaäc J, Verrijp, Kiek, Jamieson, Nigel B, Wood, Colin, Vliet, Shannon, Reuvers, Luuk, Achouiti, Soumia, Rutgers, Natasja, Brouwer, Nelleke, Simmer, Femke, Zlobec, Inti, Lugli, Alessandro, Nagtegaal, Iris D

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Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer von Kloosterman, Wigard P, Hoogstraat, Marlous, Paling, Oscar, Tavakoli-Yaraki, Masoumeh, Renkens, Ivo, Vermaat, Joost S, van Roosmalen, Markus J, van Lieshout, Stef, Nijman, Isaac J, Roessingh, Wijnand, van’t Slot, Ruben, van de Belt, José, Guryev, Victor, Koudijs, Marco, Voest, Emile, Cuppen, Edwin

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Myeloid lineage–restricted somatic mosaicism of NLRP3 mutations in patients with variant Schnitzler syndrome von de Koning, Heleen D., MD, van Gijn, Mariëlle E., MD, PhD, Stoffels, Monique, PhD, Jongekrijg, Johanna, BSc, Zeeuwen, Patrick L.J.M., PhD, Elferink, Martin G., PhD, Nijman, Isaac J., PhD, Jansen, Patrick A.M., PhD, Neveling, Kornelia, PhD, van der Meer, Jos W.M., MD, PhD, Schalkwijk, Joost, PhD, Simon, Anna, MD, PhD

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Targeted next-generation sequencing: A novel diagnostic tool for primary immunodeficiencies von Nijman, Isaac J., PhD, van Montfrans, Joris M., MD, PhD, Hoogstraat, Marlous, BAS, Boes, Marianne L., PhD, van de Corput, Lisette, PhD, Renner, Ellen D., MD, PhD, van Zon, Patrick, BSc, van Lieshout, Stef, BSc, Elferink, Martin G., PhD, van der Burg, Mirjam, PhD, Vermont, Clementien L., MD, PhD, van der Zwaag, Bert, PhD, Janson, Esther, BSc, Cuppen, Edwin, PhD, Ploos van Amstel, Johannes K., PhD, van Gijn, Marielle E., PhD

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Dutch genome diagnostic laboratories accelerated and improved variant interpretation and increased accuracy by sharing data von Fokkema, Ivo F. A. C., Velde, Kasper J., Slofstra, Mariska K., Ruivenkamp, Claudia A. L., Vogel, Maartje J., Pfundt, Rolph, Blok, Marinus J., Lekanne Deprez, Ronald H., Waisfisz, Quinten, Abbott, Kristin M., Sinke, Richard J., Rahman, Rubayte, Nijman, Isaäc J., Koning, Bart, Thijs, Gert, Wieskamp, Nienke, Moritz, Ruben J. G., Charbon, Bart, Saris, Jasper J., den Dunnen, Johan T., Laros, Jeroen F. J., Swertz, Morris A., Gijn, Marielle E.

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Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity von Josifova, Dragana J, Monroe, Glen R, Tessadori, Federico, de Graaff, Esther, van der Zwaag, Bert, Mehta, Sarju G, Harakalova, Magdalena, Duran, Karen J, Savelberg, Sanne M C, Nijman, Isaäc J, Jungbluth, Heinz, Hoogenraad, Casper C, Bakkers, Jeroen, Knoers, Nine V, Firth, Helen V, Beales, Philip L, van Haaften, Gijs, van Haelst, Mieke M

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Multiplex spatial omics reveals changes in immune-epithelial crosstalk during inflammation and dysplasia development in chronic IBD patients von Baars, Matthijs J.D., Floor, Evelien, Sinha, Neeraj, ter Linde, José J.M., van Dam, Stephanie, Amini, Mojtaba, Nijman, Isaäc J., ten Hove, Joren R., Drylewicz, Julia, Offerhaus, G.Johan A., Laclé, Miangela M., Oldenburg, Bas, Vercoulen, Yvonne

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Genomic and transcriptomic plasticity in treatment-naive ovarian cancer von Hoogstraat, Marlous, de Pagter, Mirjam S, Cirkel, Geert A, van Roosmalen, Markus J, Harkins, Timothy T, Duran, Karen, Kreeftmeijer, Jennifer, Renkens, Ivo, Witteveen, Petronella O, Lee, Clarence C, Nijman, Isaac J, Guy, Tanisha, van 't Slot, Ruben, Jonges, Trudy N, Lolkema, Martijn P, Koudijs, Marco J, Zweemer, Ronald P, Voest, Emile E, Cuppen, Edwin, Kloosterman, Wigard P

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Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing von Harakalova, Magdalena, Mokry, Michal, Hrdlickova, Barbara, Renkens, Ivo, Duran, Karen, van Roekel, Henk, Lansu, Nico, van Roosmalen, Mark, de Bruijn, Ewart, Nijman, Isaac J, Kloosterman, Wigard P, Cuppen, Edwin

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Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers von Wu, Xiaoyan, den Boer, Elise R., Vos-Loohuis, Manon, Steenbeek, Frank G. van, Monroe, Glen R., Nijman, Isaac J., Leegwater, Peter. A. J., Fieten, Hille

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