Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation von Chen, Jun, Joshi, Shailen K., DiDomenico, Stanley, Perner, Richard J., Mikusa, Joe P., Gauvin, Donna M., Segreti, Jason A., Han, Ping, Zhang, Xu-Feng, Niforatos, Wende, Bianchi, Bruce R., Baker, Scott J., Zhong, Chengmin, Simler, Gricelda H., McDonald, Heath A., Schmidt, Robert G., McGaraughty, Steve P., Chu, Katharine L., Faltynek, Connie R., Kort, Michael E., Reilly, Regina M., Kym, Philip R.

Volltext

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat von Jarvis, Michael F, Burgard, Edward C, McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J, Subieta, Alberto, Van Biesen, Tim, Cartmell, Jayne, Bianchi, Bruce, Niforatos, Wende, Kage, Karen, Yu, Haixia, Mikusa, Joe, Wismer, Carol T, Zhu, Chang Z, Chu, Katharine, Lee, Chih-Hung, Stewart, Andrew O, Polakowski, James, Cox, Bryan F, Kowaluk, Elizabeth, Williams, Michael, Sullivan, James, Faltynek, Connie

Volltext

Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597) von Niforatos, Wende, Zhang, Xu-Feng, Lake, Marc R, Walter, Karl A, Neelands, Torben, Holzman, Thomas F, Scott, Victoria E, Faltynek, Connie R, Moreland, Robert B, Chen, Jun

Volltext

Pharmacological characterization of recombinant human and rat P2X receptor subtypes von Bianchi, Bruce R, Lynch, Kevin J, Touma, Edward, Niforatos, Wende, Burgard, Edward C, Alexander, Karen M, Park, Helen S, Yu, Haixia, Metzger, Randy, Kowaluk, Elizabeth, Jarvis, Michael F, van Biesen, Tim

Volltext

P2X Receptor-Mediated Ionic Currents in Dorsal Root Ganglion Neurons von Burgard, Edward C, Niforatos, Wende, van Biesen, Tim, Lynch, Kevin J, Touma, Edward, Metzger, Randy E, Kowaluk, Elizabeth A, Jarvis, Michael F

Volltext

Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists von Chen, Jun, Lake, Marc R., Sabet, Reza S., Niforatos, Wende, Pratt, Steve D., Cassar, Steven C., Xu, Jing, Gopalakrishnan, Sujatha, Pereda-Lopez, Ana, Gopalakrishnan, Murali, Holzman, Thomas F., Moreland, Robert B., Walter, Karl A., Faltynek, Connie R., Warrior, Usha, Scott, Victoria E.

Volltext

Molecular and Functional Characterization of Human P2X2 Receptors von Kevin J. Lynch, Edward Touma, Wende Niforatos, Karen L. Kage, Edward C. Burgard, Tim van Biesen, Elizabeth A. Kowaluk, Michael F. Jarvis

Volltext

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats von Jarvis, Michael F., Scott, Victoria E., McGaraughty, Steve, Chu, Katharine L., Xu, Jun, Niforatos, Wende, Milicic, Ivan, Joshi, Shailen, Zhang, Qingwei, Xia, Zhiren

Volltext

Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists von Nelson, Derek W, Gregg, Robert J, Kort, Michael E, Perez-Medrano, Arturo, Voight, Eric A, Wang, Ying, Grayson, George, Namovic, Marian T, Donnelly-Roberts, Diana L, Niforatos, Wende, Honore, Prisca, Jarvis, Michael F, Faltynek, Connie R, Carroll, William A

Volltext

Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states von Joshi, S.K., Mikusa, Joseph P., Hernandez, Gricelda, Baker, Scott, Shieh, Char-Chang, Neelands, Torben, Zhang, Xu-Feng, Niforatos, Wende, Kage, Karen, Han, Ping, Krafte, Douglas, Faltynek, Connie, Sullivan, James P., Jarvis, Michael F., Honore, Prisca

Volltext

Alteration of dorsal root ganglion P2X 3 receptor expression and function following spinal nerve ligation in the rat von Kage, Karen, Niforatos, Wende, Zhu, Chang, Lynch, Kevin, Honore, Prisca, Jarvis, Michael

Volltext

Corrigendum to “A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats” [Biochem. Pharmacol. 89 (4)... von Jarvis, Michael F., Scott, Victoria E., McGaraughty, Steve, Chu, Katharine L., Xu, Jun, Niforatos, Wende, Milicic, Ivan, Joshi, Shailen, Zhang, Qingwei, Xia, Zhiren

Volltext

Characterization of the triazine, T4, a representative from a novel series of CaV2 inhibitors with strong state-dependence, poor use-dependence, and distinctively fast kinetics von Swensen, Andrew M., Niforatos, Wende, Lee, Chih-Hung, Jarvis, Michael F., McGaraughty, Steve

Volltext

A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain von Xu, Jun, Chu, Katharine L, Zhu, Chang Z, Niforatos, Wende, Swensen, Andrew, Searle, Xenia, Lee, Lance, Jarvis, Michael F, McGaraughty, Steve

Volltext

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats von Scott, Victoria E., Vortherms, Timothy A., Niforatos, Wende, Swensen, Andrew M., Neelands, Torben, Milicic, Ivan, Banfor, Patricia N., King, Andrew, Zhong, Chengmin, Simler, Gricelda, Zhan, Cenchen, Bratcher, Natalie, Boyce-Rustay, Janel M., Zhu, Chang Z., Bhatia, Pramila, Doherty, George, Mack, Helmut, Stewart, Andrew O., Jarvis, Michael F.

Volltext

A mixed Ca 2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain von Xu, Jun, Chu, Katharine L., Zhu, Chang Z., Niforatos, Wende, Swensen, Andrew, Searle, Xenia, Lee, Lance, Jarvis, Michael F., McGaraughty, Steve

Volltext

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models von Zhu, Chang Z, Vortherms, Timothy A, Zhang, Min, Xu, Jun, Swensen, Andrew M, Niforatos, Wende, Neelands, Torben, Milicic, Ivan, Lewis, La Geisha, Zhong, Chengmin, Gauvin, Donna, Mikusa, Joseph, Zhan, Cenchen, Pai, Madhavi, Roderwald, Victoria, Chu, Katharine L, Cole, Emily E, Bespalov, Anton, Searle, Xenia B, McGaraughty, Steve, Bitner, Robert S, Jarvis, Michael F, Bannon, Anthony W, Joshi, Shailen K, Scott, Victoria E, Lee, Chih-Hung

Volltext

2′, 3′‐ O ‐(2,4,6,Trinitrophenyl)‐ATP and A‐317491 are competitive antagonists at a slowly desensitizing chimeric human P2X 3 receptor von Neelands, Torben R, Burgard, Edward C, Uchic, Marie E, McDonald, Heath A, Niforatos, Wende, Faltynek, Connie R, Lynch, Kevin J, Jarvis, Michael F

Volltext

Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity von Beebe, Xenia, Darczak, Daria, Henry, Rodger F., Vortherms, Timothy, Janis, Richard, Namovic, Marian, Donnelly-Roberts, Diana, Kage, Karen L., Surowy, Carol, Milicic, Ivan, Niforatos, Wende, Swensen, Andrew, Marsh, Kennan C., Wetter, Jill M., Franklin, Pamela, Baker, Scott, Zhong, Chengmin, Simler, Gricelda, Gomez, Erica, Boyce-Rustay, Janel M., Zhu, Chang Z., Stewart, Andrew O., Jarvis, Michael F., Scott, Victoria E.

Volltext

Optimization of a Cav1.2 Cell Line for Use on QPatch and PatchXpress von Martin, Ruth L., Limberis, James T., Liu, Xiaoqin, Houseman, Kathryn, Su, Zhi, Niforatos, Wende, Cox, Bryan F., Gintant, Gary A.

Volltext