The Clinical Potential of Senolytic Drugs von Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.

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Cellular senescence: a key therapeutic target in aging and diseases von Zhang, Lei, Pitcher, Louise E, Yousefzadeh, Matthew J, Niedernhofer, Laura J, Robbins, Paul D, Zhu, Yi

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Epigenetics, DNA damage, and aging von Soto-Palma, Carolina, Niedernhofer, Laura J, Faulk, Christopher D, Dong, Xiao

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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues von Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

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Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy von Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, Deursen, Jan van, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O’Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, Coleman, C Norman

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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span von Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

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Nuclear Genomic Instability and Aging von Niedernhofer, Laura J, Gurkar, Aditi U, Wang, Yinsheng, Vijg, Jan, Hoeijmakers, Jan H.J, Robbins, Paul D

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Identification of HSP90 inhibitors as a novel class of senolytics von Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.

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Role of Cellular Senescence in Type II Diabetes von Narasimhan, Akilavalli, Flores, Rafael R, Robbins, Paul D, Niedernhofer, Laura J

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Senolytics reduce coronavirus-related mortality in old mice von Camell, Christina D, Yousefzadeh, Matthew J, Zhu, Yi, Prata, Larissa G P Langhi, Huggins, Matthew A, Pierson, Mark, Zhang, Lei, O'Kelly, Ryan D, Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J, Inman, Christina L, Johnson, Kurt O, Cholensky, Stephanie H, Carlson, Timothy W, LeBrasseur, Nathan K, Khosla, Sundeep, O'Sullivan, M Gerard, Allison, David B, Jameson, Stephen C, Meves, Alexander, Li, Ming, Prakash, Y S, Chiarella, Sergio E, Hamilton, Sara E, Tchkonia, Tamara, Niedernhofer, Laura J, Kirkland, James L, Robbins, Paul D

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Senolytics improve physical function and increase lifespan in old age von Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.

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Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice von Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors von Zhu, Yi, Tchkonia, Tamara, Fuhrmann‐Stroissnigg, Heike, Dai, Haiming M., Ling, Yuanyuan Y., Stout, Michael B., Pirtskhalava, Tamar, Giorgadze, Nino, Johnson, Kurt O., Giles, Cory B., Wren, Jonathan D., Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L.

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DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria von Karakasilioti, Ismene, Kamileri, Irene, Chatzinikolaou, Georgia, Kosteas, Theodoros, Vergadi, Eleni, Robinson, Andria Rasile, Tsamardinos, Iannis, Rozgaja, Tania A., Siakouli, Sandra, Tsatsanis, Christos, Niedernhofer, Laura J., Garinis, George A.

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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis von Farr, Joshua N, Saul, Dominik, Doolittle, Madison L, Kaur, Japneet, Rowsey, Jennifer L, Vos, Stephanie J, Froemming, Mitchell N, Lagnado, Anthony B, Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J, Niedernhofer, Laura J, Robbins, Paul D, Jurk, Diana, Passos, João F, LeBrasseur, Nathan K, Tchkonia, Tamara, Kirkland, James L, Monroe, David G, Khosla, Sundeep

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Aging and chronic inflammation: highlights from a multidisciplinary workshop von Saavedra, Danay, Añé-Kourí, Ana Laura, Barzilai, Nir, Caruso, Calogero, Cho, Kyung-Hyun, Fontana, Luigi, Franceschi, Claudio, Frasca, Daniela, Ledón, Nuris, Niedernhofer, Laura J, Pereira, Karla, Robbins, Paul D, Silva, Alexa, Suarez, Gisela M, Berghe, Wim Vanden, von Zglinicki, Thomas, Pawelec, Graham, Lage, Agustín

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Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome von Mu, Xiaodong, Tseng, Chieh, Hambright, William S., Matre, Polina, Lin, Chih‐Yi, Chanda, Palas, Chen, Wanqun, Gu, Jianhua, Ravuri, Sudheer, Cui, Yan, Zhong, Ling, Cooke, John P., Niedernhofer, Laura J., Robbins, Paul D., Huard, Johnny

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Extending human healthspan and longevity: a symposium report von DeVito, Loren M., Barzilai, Nir, Cuervo, Ana Maria, Niedernhofer, Laura J., Milman, Sofiya, Levine, Morgan, Promislow, Daniel, Ferrucci, Luigi, Kuchel, George A., Mannick, Joan, Justice, Jamie, Gonzales, Mitzi M., Kirkland, James L., Cohen, Pinchas, Campisi, Judith

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Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease von Xun, Zhiyin, Rivera-Sánchez, Sulay, Ayala-Peña, Sylvette, Lim, James, Budworth, Helen, Skoda, Erin M., Robbins, Paul D., Niedernhofer, Laura J., Wipf, Peter, McMurray, Cynthia T.

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Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation von Zhao, Jing, Zhang, Lei, Mu, Xiaodong, Doebelin, Christelle, Nguyen, William, Wallace, Callen, Reay, Daniel P, McGowan, Sara J, Corbo, Lana, Clemens, Paula R, Wilson, Gabriela Mustata, Watkins, Simon C, Solt, Laura A, Cameron, Michael D, Huard, Johnny, Niedernhofer, Laura J, Kamenecka, Theodore M, Robbins, Paul D

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