The molecular regulation of Janus kinase (JAK) activation von Babon, Jeffrey J, Lucet, Isabelle S, Murphy, James M, Nicola, Nicos A, Varghese, Leila N

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The molecular basis of JAK/STAT inhibition by SOCS1 von Liau, Nicholas P. D., Laktyushin, Artem, Lucet, Isabelle S., Murphy, James M., Yao, Shenggen, Whitlock, Eden, Callaghan, Kimberley, Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J.

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The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism von Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.

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Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity von Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.

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The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments von Zhang, Jian-Guo, Czabotar, Peter E., Policheni, Antonia N., Caminschi, Irina, San Wan, Soo, Kitsoulis, Susie, Tullett, Kirsteen M., Robin, Adeline Y., Brammananth, Rajini, van Delft, Mark F., Lu, Jinhua, O'Reilly, Lorraine A., Josefsson, Emma C., Kile, Benjamin T., Chin, Wei Jin, Mintern, Justine D., Olshina, Maya A., Wong, Wilson, Baum, Jake, Wright, Mark D., Huang, David C.S., Mohandas, Narla, Coppel, Ross L., Colman, Peter M., Nicola, Nicos A., Shortman, Ken, Lahoud, Mireille H.

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Inhibition of IL-6 family cytokines by SOCS3 von Babon, Jeffrey J, Varghese, Leila N, Nicola, Nicos A

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SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition von Kershaw, Nadia J, Murphy, James M, Liau, Nicholas P D, Varghese, Leila N, Laktyushin, Artem, Whitlock, Eden L, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J

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Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells von Ushiki, Takashi, Huntington, Nicholas D, Glaser, Stefan P, Kiu, Hiu, Georgiou, Angela, Zhang, Jian-Guo, Metcalf, Donald, Nicola, Nicos A, Roberts, Andrew W, Alexander, Warren S

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Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity von D'Cruz, Akshay A, Babon, Jeffrey J, Norton, Raymond S, Nicola, Nicos A, Nicholson, Sandra E

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Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin von Sarson-Lawrence, Kaiseal T. G., Hardy, Joshua M., Iaria, Josephine, Stockwell, Dina, Behrens, Kira, Saiyed, Tamanna, Tan, Cyrus, Jebeli, Leila, Scott, Nichollas E., Dite, Toby A., Nicola, Nicos A., Leis, Andrew P., Babon, Jeffrey J., Kershaw, Nadia J.

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Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice von Walker, Emma C, McGregor, Narelle E, Poulton, Ingrid J, Solano, Melissa, Pompolo, Sueli, Fernandes, Tania J, Constable, Matthew J, Nicholson, Geoff C, Zhang, Jian-Guo, Nicola, Nicos A, Gillespie, Matthew T, Martin, T John, Sims, Natalie A

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DEC-205 is a cell surface receptor for CpG oligonucleotides von Lahoud, Mireille H, Ahmet, Fatma, Zhang, Jian-Guo, Meuter, Simone, Policheni, Antonia N, Kitsoulis, Susie, Lee, Chin-Nien, O’Keeffe, Meredith, Sullivan, Lucy C, Brooks, Andrew G, Berry, Richard, Rossjohn, Jamie, Mintern, Justine D, Vega-Ramos, Javier, Villadangos, Jose A, Nicola, Nicos A, Nussenzweig, Michel C, Stacey, Katryn J, Shortman, Ken, Heath, William R, Caminschi, Irina

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Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection von Kedzierski, Lukasz, Linossi, Edmond M, Kolesnik, Tatiana B, Day, E Bridie, Bird, Nicola L, Kile, Benjamin T, Belz, Gabrielle T, Metcalf, Donald, Nicola, Nicos A, Kedzierska, Katherine, Nicholson, Sandra E

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Leukemia inhibitory factor (LIF) von Nicola, Nicos A, Babon, Jeffrey J

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Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice von Winship, Amy, Correia, Jeanne, Zhang, Jian-Guo, Nicola, Nicos A, Dimitriadis, Evdokia

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Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling von Kedzierski, Lukasz, Tate, Michelle D, Hsu, Alan C, Kolesnik, Tatiana B, Linossi, Edmond M, Dagley, Laura, Dong, Zhaoguang, Freeman, Sarah, Infusini, Giuseppe, Starkey, Malcolm R, Bird, Nicola L, Chatfield, Simon M, Babon, Jeffrey J, Huntington, Nicholas, Belz, Gabrielle, Webb, Andrew, Wark, Peter Ab, Nicola, Nicos A, Xu, Jianqing, Kedzierska, Katherine, Hansbro, Philip M, Nicholson, Sandra E

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Hhex Regulates Hematopoietic Stem Cell Self‐Renewal and Stress Hematopoiesis via Repression of Cdkn2a von Jackson, Jacob T., Shields, Benjamin J., Shi, Wei, Di Rago, Ladina, Metcalf, Donald, Nicola, Nicos A., McCormack, Matthew P.

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Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling von D'Cruz, Akshay A, Kershaw, Nadia J, Chiang, Jessica J, Wang, May K, Nicola, Nicos A, Babon, Jeffrey J, Gack, Michaela U, Nicholson, Sandra E

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Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy Loss von Winship, Amy, Correia, Jeanne, Krishnan, Tara, Menkhorst, Ellen, Cuman, Carly, Zhang, Jian-Guo, Nicola, Nicos A., Dimitriadis, Evdokia

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Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses von Varghese, Leila N, Ungureanu, Daniela, Liau, Nicholas P D, Young, Samuel N, Laktyushin, Artem, Hammaren, Henrik, Lucet, Isabelle S, Nicola, Nicos A, Silvennoinen, Olli, Babon, Jeffrey J, Murphy, James M

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