Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123 von Gauthier, Laurent, Virone-Oddos, Angela, Beninga, Jochen, Rossi, Benjamin, Nicolazzi, Céline, Amara, Céline, Blanchard-Alvarez, Audrey, Gourdin, Nicolas, Courta, Jacqueline, Basset, Alexandra, Agnel, Magali, Guillot, Franceline, Grondin, Gwendoline, Bonnevaux, Hélène, Bauchet, Anne-Laure, Morel, Ariane, Morel, Yannis, Chiron, Marielle, Vivier, Eric

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Preclinical Activity of SAR408701: A Novel Anti-CEACAM5-maytansinoid Antibody-drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors von Decary, Stephanie, Berne, Pierre-Francois, Nicolazzi, Celine, Lefebvre, Anne-Marie, Dabdoubi, Tarik, Cameron, Beatrice, Rival, Pierrick, Devaud, Catherine, Prades, Catherine, Bouchard, Herve, Casse, Alhassan, Henry, Christophe, Amara, Celine, Brillac, Claire, Ferrari, Paul, Macon, Laetitia, Lacoste, Eric, Combeau, Cecile, Beys, Eric, Naimi, Souad, Garcia-Echeverria, Carlos, Mayaux, Jean-Francois, Blanc, Veronique

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An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities von Nicolazzi, Celine, Caron, Anne, Tellier, Alexia, Trombe, Marc, Pinkas, Jan, Payne, Gillian, Carrez, Chantal, Guerif, Stephane, Maguin, Marie, Baffa, Raffaele, Fassan, Matteo, Adam, Julien, Mangatal-Wade, Lydie, Blanc, Veronique

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SAR442085, a novel anti-CD38 antibody with enhanced antitumor activity against multiple myeloma von Kassem, Sahar, Diallo, Béré K., El-Murr, Nizar, Carrié, Nadège, Tang, Alexandre, Fournier, Alain, Bonnevaux, Hélène, Nicolazzi, Céline, Cuisinier, Marine, Arnould, Isabelle, Sidhu, Sukhvinder S., Corre, Jill, Avet-Loiseau, Hervé, Teillaud, Jean-Luc, van de Velde, Helgi, Wiederschain, Dmitri, Chiron, Marielle, Martinet, Ludovic, Virone-Oddos, Angela

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The search for therapeutic targets in lung cancer: Preclinical and human studies of carcinoembryonic antigen-related cell adhesion molecule 5 expression and its associated molecula... von Lefebvre, Anne-Marie, Adam, Julien, Nicolazzi, Céline, Larois, Christelle, Attenot, Florence, Falda-Buscaiot, François, Dib, Colette, Masson, Nina, Ternès, Nils, Bauchet, Anne-Laure, Demers, Brigitte, Chadjaa, Mustapha, Sidhu, Sukhvinder, Combeau, Cécile, Soria, Jean-Charles, Scoazec, Jean-Yves, Naimi, Souad, Angevin, Eric, Chiron, Marielle, Henry, Christophe

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A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility von Vecchione, Loredana, Gambino, Valentina, Raaijmakers, Jonne, Schlicker, Andreas, Fumagalli, Arianna, Russo, Mariangela, Villanueva, Alberto, Beerling, Evelyne, Bartolini, Alice, Mollevi, David G., El-Murr, Nizar, Chiron, Marielle, Calvet, Loreley, Nicolazzi, Céline, Combeau, Cécile, Henry, Christophe, Simon, Iris M., Tian, Sun, in ‘t Veld, Sjors, D’ario, Giovanni, Mainardi, Sara, Beijersbergen, Roderick L., Lieftink, Cor, Linn, Sabine, Rumpf-Kienzl, Cornelia, Delorenzi, Mauro, Wessels, Lodewyk, Salazar, Ramon, Di Nicolantonio, Federica, Bardelli, Alberto, van Rheenen, Jacco, Medema, René H., Tejpar, Sabine, Bernards, René

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Translational Model‐Based Strategy to Guide the Choice of Clinical Doses for Antibody–Drug Conjugates von Bouillon‐Pichault, Marion, Brillac, Claire, Amara, Céline, Nicolazzi, Céline, Fagniez, Nathalie, Fau, Jean‐Baptiste, Koiwai, Kimiko, Ziti‐Ljajic, Samira, Veyrat‐Follet, Christine

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Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours von Seguin, Johanne, Nicolazzi, Céline, Mignet, Nathalie, Scherman, Daniel, Chabot, Guy G.

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DTS-108, A Novel Peptidic Prodrug of SN38: In vivo Efficacy and Toxicokinetic Studies von MEYER-LOSIC, Florence, NICOLAZZI, Céline, ARRANZ, Valérie, ZOUBAA, Imane, FRUCHART, Jean-Sébastien, RAVEL, Denis, KEARSEY, Jonathan, QUINONERO, Jérome, RIBES, Fabien, MICHEL, Matthieu, DUBOIS, Vincent, DE COUPADE, Catherine, BOUKAISSI, Matthieu, CHENE, Anne-Sophie, TRANCHANT, Isabelle

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Abstract 5179: Isatuximab based combinations induce potent tumor growth inhibition in pre-clinical models of multiple myeloma and acute lymphocytic leukemia von Zhu, Chen, Nicolazzi, Celine, de Velde, Helgi Van, Wiederschain, Dmitri, Sidhu, Sukhvinder, Chiron, Marielle

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Preclinical Toxicity, Toxicokinetics, and Antitumoral Efficacy Studies of DTS-201, a Tumor-Selective Peptidic Prodrug of Doxorubicin von RAVEL, Denis, DUBOIS, Vincent, VIALATTE, Karine, HOR, Inès, KEARSEY, Jonathan, TROUET, André, QUINONERO, Jerome, MEYER-LOSIC, Florence, DELORD, Jean Pierre, ROCHAIX, Philippe, NICOLAZZI, Céline, RIBES, Fabien, MAZEROLLES, Catherine, ASSOULY, Elise

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Evaluation of Preclinical Activity of Isatuximab in Patients with Acute Lymphoblastic Leukemia von Wang, Anlai, Song, Zhili, Zheng, Gang, Nicolazzi, Celine, Fromm, Jonathan R., Shehu, Elvis, Srinivasan, Srimathi, Chen, Xueyan, Zhu, Chen, Blondel, Marielle Chiron, Adrian, Francisco J.

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Abstract 561: Preclinical efficacy data for the anti-CEACAM5-DM4 ADC SAR408701 supports further development in lung and gastro-intestinal cancers von Decary, Stephanie, Lemaitre, Olivier, Lefebvre, Anne-Marie, Ferrier, Alexandra, Chiron, Marielle, Wiederschain, Dmitri, Lacoste-Bourgeacq, Anne-Sophie, Bail, Nathalie Le, Sidhu, Sukhvinder, Combeau, Cecile, Chadjaa, Mustapha, Nicolazzi, Celine

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852 Trifunctional NKp46/CD16a-NK cell engager targeting CD123 overcomes acute myeloid leukemia resistance to ADCC von Gauthier, Laurent, Virone-Oddos, Angela, Beninga, Jochen, Rossi, Benjamin, Nicolazzi, Céline, Amara, Céline, Blanchard-Alvarez, Audrey, Gourdin, Nicolas, Courta, Jacqueline, Basset, Alexandra, Guillot, Franceline, Grondin, Gwendoline, Bonnevaux, Hélène, Bauchet, Anne-Laure, Morel, Ariane, Morel, Yannis, Chiron, Marielle, Vivier, Eric

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Abstract 235: Preclinical activity of an antibody drug conjugate targeting tumor specificmuc1 structural peptide-glycotope von Trombe, Marc, Caron, Anne, Tellier, Alexia, Carrez, Chantal, Guérif, Stephane, Clavier, Severine, Karst, Nathalie, Saarinen, Juhani, Satomaa, Tero, Pitkänen, Virve, Aitio, Olli, Heiskanen, Annamari, Fassan, Matteo, Pinkas, Jan, Baffa, Raffaele, Blanc, Veronique, Nicolazzi, Celine

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Abstract 4890: A novel topoisomerase I inhibitor antibody-drug conjugate targeting CEACAM5 has potent anti-tumor activity in colorectal cancer models von Baudat, Yves, Neff-LaFord, Haley, Nicolazzi, Celine, Meyer, Dave, Sigurjonsson, Johann Petur, Lyski, Ryan, Fantin, Valeria, Brun, Marie-Priscille, Chiron, Marielle, Decary, Stephanie

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Abstract 1197: Outstanding preclinical efficacy of a novel maytansinoid-antibody-drug conjugate targeting LAMP1 in patient-derived xenograft solid tumors von Calvet, Loreley, Lefebvre, Anne-Marie, Nicolazzi, Celine, Blot, Lydia, Thomas, Corinne, Baudat, Yves, Cameron, Beatrice, Garcia-Echeverria, Carlos, Mayaux, Jean-Francois, Blanc, Veronique, Combeau, Cecile, Naimi, Souad, Sidhu, Sukhvinder

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Abstract 3269: Ablation of Cbl-b gene function leads to increased activation and resistance to immunosuppression in human primary T lymphocytes von Parmantier, Eric, Kalouche, Georges, Soulard, Clara, Lanneau, Christophe, Boisrobert-Blais, Sophie, Nicolazzi, Céline, Orsini, Cécile

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An antibody drug conjugate targeting MUC1 associated carbohydrate CA6, shows promising anti-tumor activities von Nicolazzi, Celine, Caron, Anne, Tellier, Alexia, Trombe, Marc, Pinkas, Jan, Payne, Gillian, Carrez, Chantal, Guerif, Stephane, Maguin, Marie, Baffa, Raffaele, Fassan, Matteo, Adam, Julien, Mangatal-Wade, Lydie, Blanc, Veronique

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ANTITUMOR COMBINATIONS CONTAINING ANTI-CEACAM5 ANTIBODY CONJUGATES, TRIFLURIDINE AND TIPIRACIL von NICOLAZZI, CELINE

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