Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies von Nichols, T. C., Hough, C., Agersø, H., Ezban, M., Lillicrap, D.

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Protease-Resistant Insulin-Like Growth Factor (IGF)-Binding Protein-4 Inhibits IGF-I Actions and Neointimal Expansion in a Porcine Model of Neointimal Hyperplasia von Nichols, T. C, Busby, W. H, Merricks, E, Sipos, J, Rowland, M, Sitko, K, Clemmons, D. R

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Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia von MONAHAN, P. E, SAMULSKI, R. J, TAZELAAR, J, XIAO, X, NICHOLS, T. C, BELLINGER, D. A, READ, M. S, WALSH, C. E

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Persistent expression of canine factor IX in hemophilia B canines von CHAO, H, SAMULSKI, R. J, BELLINGER, D. A, MONAHAN, P. E, NICHOLS, T. C, WALSH, C. E

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Intravenous administration of an AAV-2 vector for the expression of factor IX in mice and a dog model of hemophilia B von HARDING, T. C, KOPRIVNIKAR, K. E, NICHOLS, T. C, BELLINGER, D. A, YENDLURI, S, WAUGH, J, MCARTHUR, J, VERES, G, DONAHUE, B. A, TU, G. H, ZAYEK, N, LEW, S, SUBRAMANIAN, A, SIVAKUMARAN, A, FREY, D, HO, K, VANROEY, M. J

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An anti-αVβ3 antibody inhibits coronary artery atherosclerosis in diabetic pigs von Maile, L.A, Busby, W.H, Xi, G, Gollahan, K.P, Flowers, W, Gafbacik, N, Gafbacik, S, Stewart, K, Merricks, E.P, Nichols, T.C, Bellinger, D.A, Clemmons, D.R

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Pharmacokinetics of Recombinant Factor IX after Intravenous and Subcutaneous Administration in Dogs and Cynomolgus Monkeys von McCarthy, K., Stewart, P., Sigman, J., Read, M., Keith, J. C., Brinkhous, K. M., Nichols, T. C., Schaub, R. G.

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Improved kinetics of rIX‐FP, a recombinant fusion protein linking factor IX with albumin, in cynomolgus monkeys and hemophilia B dogs von NOLTE, M. W., NICHOLS, T. C., MUELLER‐COHRS, J., MERRICKS, E. P., PRAGST, I., ZOLLNER, S., DICKNEITE, G.

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Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs von Agersø, H., Stennicke, H. R., Pelzer, H., Olsen, E. N., Merricks, E. P., deFriess, N. A., Nichols, T. C., Ezban, M.

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Porphyromonas gingivalis Bacteremia Induces Coronary and Aortic Atherosclerosis in Normocholesterolemic and Hypercholesterolemic Pigs von Brodala, Nadine, Merricks, Elizabeth P, Bellinger, Dwight A, Damrongsri, Damrong, Offenbacher, Steven, Beck, James, Madianos, Phoebus, Sotres, Daniela, Chang, Yu-Ling, Koch, Gary, Nichols, Timothy C

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Haemophilic factors produced by transgenic livestock: abundance that can enable alternative therapies worldwide von Van Cott, K. E., Monahan, P. E., Nichols, T. C., Velander, W. H.

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Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency von Nichols, Timothy C, Dillow, Aaron M, Franck, Helen W.G, Merricks, Elizabeth P, Raymer, Robin A, Bellinger, Dwight A, Arruda, Valder R, High, Katherine A

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Sensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post‐transfusion elimination time o... von NICHOLS, T. C., FRANCK, H. W. G., FRANCK, C. T., de FRIESS, N., RAYMER, R. A., MERRICKS, E. P.

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Helper‐dependent adenoviral gene therapy mediates long‐term correction of the clotting defect in the canine hemophilia A model von McCORMACK, W. M., SEILER, M. P., BERTIN, T. K., UBHAYAKAR, K., PALMER, D. J., NG, P., NICHOLS, T. C., LEE, B.

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Intratracheal Administration of Recombinant Human Factor IX (BeneFix ) Achieves Therapeutic Levels in Hemophilia B Dogs von Russell, K. E., Read, M. S., Bellinger, D. A., Leitermann, K., Rup, B. J., McCarthy, K. P., Keith, J. C., Khor, S. P., Schaub, R. G., Nichols, T. C.

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Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs von KARPF, D. M., KJALKE, M., THIM, L., AGERSØ, H., MERRICKS, E. P., DEFRIESS, N., NICHOLS, T. C., EZBAN, M.

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Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction von Bleich, Stanley D., Nichols, Timothy C., Schumacher, Richard R., Cooke, David H., Tate, David A., Teichman, Sam L.

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Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector von High, Katherine A, Herzog, Roland W, Yang, Edmund Y, Couto, Linda B, Hagstrom, J. Nathan, Elwell, Dan, Fields, Paul A, Burton, Melissa, Bellinger, Dwight A, Read, Marjorie S, Brinkhous, Kenneth M, Podsakoff, Gregory M, Nichols, Timothy C, Kurtzman, Gary J

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Preservation of Hemostatic and Structural Properties of Rehydrated Lyophilized Platelets: Potential for Long-Term Storage of Dried Platelets for Transfusion von Read, Marjorie S., Reddick, Robert L., Bode, Arthur P., Bellinger, Dwight A., Nichols, Timothy C., Taylor, Kathryn, Smith, Scott V., McMahon, Debra K., Giggs, Thomas R., Brinkhous, Kenneth M.

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Distinguishing Migratory and Resident Canada Geese Using Stable Isotope Analysis von Caccamise, Donald F., Reed, Lisa M., Castelli, Paul M., Wainright, Sam, Nichols, Ted C.

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