Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH von Surdo, Paola Lo, Bottomley, Matthew J, Calzetta, Alessandra, Settembre, Ethan C, Cirillo, Agostino, Pandit, Shilpa, Ni, Yan G, Hubbard, Brian, Sitlani, Ayesha, Carfí, Andrea

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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases von Ni, Yan G, Wang, Na, Cao, Dian J, Sachan, Nita, Morris, David J, Gerard, Robert D, Kuro-o, Makoto, Rothermel, Beverly A, Hill, Joseph A

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Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling von NI, Yan G, BERENJI, Kambeez, GERARD, Robert D, ROTHERMEL, Beverly A, HILL, Joseph A, NA WANG, OH, Misook, SACHAN, Nita, DEY, Asim, JUN CHENG, GUANGRONG LU, MORRIS, David J, CASTRILLON, Diego H

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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes von Zhang, Liwen, McCabe, Timothy, Condra, Jon H, Ni, Yan G, Peterson, Laurence B, Wang, Weirong, Strack, Alison M, Wang, Fubao, Pandit, Shilpa, Hammond, Holly, Wood, Dana, Lewis, Dale, Rosa, Ray, Mendoza, Vivienne, Cumiskey, Anne Marie, Johns, Douglas G, Hansen, Barbara C, Shen, Xun, Geoghagen, Neil, Jensen, Kristian, Zhu, Lei, Wietecha, Karol, Wisniewski, Douglas, Huang, Lingyi, Zhao, Jing Zhang, Ernst, Robin, Hampton, Richard, Haytko, Peter, Ansbro, Frances, Chilewski, Shannon, Chin, Jayne, Mitnaul, Lyndon J, Pellacani, Andrea, Sparrow, Carl P, An, Zhiqiang, Strohl, William, Hubbard, Brian, Plump, Andrew S, Blom, Daniel, Sitlani, Ayesha

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Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice von Fattori, Elena, Cappelletti, Manuela, Lo Surdo, Paola, Calzetta, Alessandra, Bendtsen, Claus, Ni, Yan G., Pandit, Shilpa, Sitlani, Ayesha, Mesiti, Giuseppe, Carfí, Andrea, Monaci, Paolo

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Regulators of G-Protein Signaling (RGS) Proteins: Region-Specific Expression of Nine Subtypes in Rat Brain von Gold, Stephen J, Ni, Yan G, Dohlman, Henrik G, Nestler, Eric J

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Best practices for the development and fit-for-purpose validation of biomarker methods: a conference report von Mathews, Joel, Amaravadi, Lakshmi, Eck, Steven, Stevenson, Lauren, Wang, Yow-Ming C., Devanarayan, Viswanath, Allinson, John, Lundsten, Kelly, Gunsior, Michele, Ni, Yan G., Pepin, Marc-Olivier, Gagnon, Audrey, Sheldon, Curtis, Trampont, Paul C., Litwin, Virginia

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Best Practices for Development and Validation of Enzymatic Activity Assays to Support Drug Development for Inborn Errors of Metabolism and Biomarker Assessment von Azadeh, Mitra, Good, Jeremy, Gunsior, Michele, Kulagina, Nadia, Lu, Yanmei, McNally, Jim, Myler, Heather, Ni, Yan G., Pelto, Ryan, Quadrini, Karen J., Vrentas, Catherine, Yang, Lin

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Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease von Ozen, Ahmet, Kasap, Nurhan, Vujkovic-Cvijin, Ivan, Apps, Richard, Cheung, Foo, Karakoc-Aydiner, Elif, Akkelle, Bilge, Sari, Sinan, Tutar, Engin, Ozcay, Figen, Uygun, Dilara Kocacik, Islek, Ali, Akgun, Gamze, Selcuk, Merve, Sezer, Oya Balci, Zhang, Yu, Kutluk, Gunsel, Topal, Erdem, Sayar, Ersin, Celikel, Cigdem, Houwen, Roderick H. J., Bingol, Aysen, Ogulur, Ismail, Eltan, Sevgi Bilgic, Snow, Andrew L., Lake, Camille, Fantoni, Giovanna, Alba, Camille, Sellers, Brian, Chauvin, Samuel D., Dalgard, Clifton L., Harari, Olivier, Ni, Yan G., Wang, Ming-Dauh, Devalaraja-Narashimha, Kishor, Subramanian, Poorani, Ergelen, Rabia, Artan, Reha, Guner, Sukru Nail, Dalgic, Buket, Tsang, John, Belkaid, Yasmine, Ertem, Deniz, Baris, Safa, Lenardo, Michael J.

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PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo von Ni, Yan G, Di Marco, Stefania, Condra, Jon H, Peterson, Laurence B, Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A, Rosa, Ray, Cummings, Richard T, Wood, Dana D, Liu, Xiaomei, Bottomley, Matthew J, Shen, Xun, Cubbon, Rose M, Wang, Sheng-ping, Johns, Douglas G, Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J, Sparrow, Carl P, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

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Considerations for Soluble Protein Biomarker Blood Sample Matrix Selection von Mathews, Joel A., Ni, Yan G., Wang, Connie, Peterson, Jon E., Ray, Chad, Zhao, Xuemei, Duan, Daoyu, Hamon, Sara, Allinson, John, Hokom, Martha, Wegner, Greta

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Validation of high-sensitivity assays to quantitate cerebrospinal fluid and serum β-galactosidase activity in patients with GM1-gangliosidosis von Quadrini, Karen J., Vrentas, Catherine, Duke, Christian, Wilson, Chris, Hinderer, Christian J., Weinstein, David A., Al-Zaidy, Samiah A., Browne, Susan E., Wilson, James M., Ni, Yan G.

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2015 White Paper on Recent Issues in Bioanalysis: Focus on New Technologies and Biomarkers (Part 3 – Lba, Biomarkers and Immunogenicity) von Amaravadi, Lakshmi, Song, An, Myler, Heather, Thway, Theingi, Kirshner, Susan, Devanarayan, Viswanath, Ni, Yan G, Garofolo, Fabio, Birnboeck, Herbert, Richards, Susan, Gupta, Shalini, Luo, Linlin, Kingsley, Clare, Salazar-Fontana, Laura, Fraser, Stephanie, Gorovits, Boris, Allinson, John, Barger, Troy, Chilewski, Shannon, Fjording, Marianne Scheel, Haidar, Sam, Islam, Rafiqul, Jaitner, Birgit, Kamerud, John, Katori, Noriko, Krinos-Fiorotti, Corinna, Lanham, David, Ma, Mark, McNally, Jim, Morimoto, Alyssa, Mytych, Daniel, Nogueira da Costa, Andre, Papadimitriou, Apollon, Pillutla, Renuka, Ray, Soma, Safavi, Afshin, Savoie, Natasha, Schaefer, Martin, Shih, Judy, Smeraglia, John, Skelly, Michael F, Spond, Jeffrey, Staack, Roland F, Stouffer, Bruce, Tampal, Nilufer, Torri, Albert, Welink, Jan, Yang, Tong-Yuan, Zoghbi, Jad

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FoxO, Autophagy, and Cardiac Remodeling von Ferdous, Anwarul, Battiprolu, Pavan K., Ni, Yan G., Rothermel, Beverly A., Hill, Joseph A.

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Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay von Ni, Yan G., Yuan, Xiling, Newitt, John A., Peterson, Jon E., Gleason, Carol R., Haulenbeek, Jonathan, Santockyte, Rasa, Lafont, Virginie, Marsilio, Frank, Neely, Robert J., DeSilva, Binodh, Piccoli, Steven P.

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A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein... von Ni, Yan G., Condra, Jon H., Orsatti, Laura, Shen, Xun, Di Marco, Stefania, Pandit, Shilpa, Bottomley, Matthew J., Ruggeri, Lionello, Cummings, Richard T., Cubbon, Rose M., Santoro, Joseph C., Ehrhardt, Anka, Lewis, Dale, Fisher, Timothy S., Ha, Sookhee, Njimoluh, Leila, Wood, Dana D., Hammond, Holly A., Wisniewski, Douglas, Volpari, Cinzia, Noto, Alessia, Lo Surdo, Paola, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

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Regulation of RGS proteins by chronic morphine in rat locus coeruleus von Gold, Stephen J., Han, Ming-Hu, Herman, Amy E., Ni, Yan G., Pudiak, Cindy M., Aghajanian, George K., Liu, Rong-Jian, Potts, Bryan W., Mumby, Susanne M., Nestler, Eric J.

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Distribution of serotonin 2A, 2C and 3 receptor mRNA in spinal cord and medulla oblongata von Fonseca, Maria I., Ni, Yan G., Dunning, Daniel D., Miledi, Ricardo

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Development and Fit-for-Purpose Validation of a Soluble Human Programmed Death-1 Protein Assay von Ni, Yan G., Yuan, Xiling, Newitt, John A., Peterson, Jon E., Gleason, Carol R., Haulenbeek, Jonathan, Santockyte, Rasa, Lafont, Virginie, Marsilio, Frank, Neely, Robert J., DeSilva, Binodh, Piccoli, Steven P.

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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S] von Ni, Yan G., Di Marco, Stefania, Condra, Jon H., Peterson, Laurence B., Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A., Rosa, Ray, Cummings, Richard T., Wood, Dana D., Liu, Xiaomei, Bottomley, Matthew J., Shen, Xun, Cubbon, Rose M., Wang, Sheng-ping, Johns, Douglas G., Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J., Sparrow, Carl P., Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

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