Function, mechanism and drug discovery of ubiquitin and ubiquitin-like modification with multiomics profiling for cancer therapy von Jiang, Yanyu, Ni, Shuaishuai, Xiao, Biying, Jia, Lijun

Volltext

Reactive oxygen species (ROS)-response nanomedicine through knocking down a novel therapeutic target NEDD8-conjugating enzyme UBC12 (UBE2M) in the treatment of liver cancer von Zhang, Zhanxia, Heng, Yongqing, Cheng, Wei, Pan, Yongfu, Ni, Shuaishuai, Li, Hegen

Volltext

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway von Wei, Jinlian, Chen, Xin, Li, Yongyun, Li, Ruoxi, Bao, Keting, Liao, Liang, Xie, Yuqing, Yang, Tiannuo, Zhu, Jin, Mao, Fei, Ni, Shuaishuai, Jia, Renbing, Xu, Xiaofang, Li, Jian

Volltext

Trilogy of drug repurposing for developing cancer and chemotherapy-induced heart failure co-therapy agent von Chen, Xin, Mu, Xianggang, Ding, Lele, Wang, Xi, Mao, Fei, Wei, Jinlian, Liu, Qian, Xu, Yixiang, Ni, Shuaishuai, Jia, Lijun, Li, Jian

Volltext

Discovering Potent Small Molecule Inhibitors of Cyclophilin A Using de Novo Drug Design Approach von Ni, Shuaishuai, Yuan, Yaxia, Huang, Jin, Mao, Xiaona, Lv, Maosheng, Zhu, Jin, Shen, Xu, Pei, Jianfeng, Lai, Luhua, Jiang, Hualiang, Li, Jian

Volltext

Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells von Ni, Shuaishuai, Liu, Qian, Chen, Xin, Ding, Lele, Cai, Lili, Mao, Fei, Shi, Donglei, Hoffman, Robert M., Li, Jian, Jia, Lijun

Volltext

Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo von Chen, Xin, Yang, Xi, Mao, Fei, Wei, Jinlian, Xu, Yixiang, Li, Baoli, Zhu, Jin, Ni, Shuaishuai, Jia, Lijun, Li, Jian

Volltext

Targeting virulence factors as an antimicrobial approach: Pigment inhibitors von Ni, Shuaishuai, Li, Baoli, Xu, Yixiang, Mao, Fei, Li, Xiaokang, Lan, Lefu, Zhu, Jin, Li, Jian

Volltext

Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity von Li, Baoli, Ni, Shuaishuai, Mao, Fei, Chen, Feifei, Liu, Yifu, Wei, Hanwen, Chen, Wenhua, Zhu, Jin, Lan, Lefu, Li, Jian

Volltext

Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction von Huang, Yunyuan, Xu, Yixiang, Song, Rongrong, Ni, Shuaishuai, Liu, Jiaqi, Xu, Yanhong, Ren, Yanliang, Rao, Li, Wang, Yingjie, Wei, Lin, Feng, Lingling, Su, Chen, Peng, Chao, Li, Jian, Wan, Jian

Volltext

Neddylation Inactivation Facilitates FOXO3a Nuclear Export to Suppress Estrogen Receptor Transcription and Improve Fulvestrant Sensitivity von Jia, Xiaoqing, Li, Chunjie, Li, Lihui, Liu, Xiaoli, Zhou, Lisha, Zhang, Wenjuan, Ni, Shuaishuai, Lu, Yun, Chen, Li, Jeong, Lak Shin, Yu, Jinha, Zhang, Yingjian, Zhang, Jianping, He, Simin, Hu, Xin, Sun, Hefen, Yu, Keda, Liu, Guangyu, Zhao, Hu, Zhang, Yanmei, Jia, Lijun, Shao, Zhi-Ming

Volltext

Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer von Chen, Yang, Cui, Yunxia, Sun, Xiao, Wu, Huiwen, Ou, Manjiao, Tang, Yunzhe, Ni, Shuaishuai, Li, Xiaokang, Zhu, Jin, Mao, Fei, Wang, Yudong, Li, Jian

Volltext

Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo von Chen, Xin, Yang, Xi, Mao, Fei, Wei, Jinlian, Xu, Yixiang, Li, Baoli, Zhu, Jin, Ni, Shuaishuai, Jia, Lijun, Li, Jian

Volltext

Discovery of candesartan cilexetic as a novel neddylation inhibitor for suppressing tumor growth von Ni, Shuaishuai, Chen, Xin, Yu, Qing, Xu, Yixiang, Hu, Zhiguo, Zhang, Junqian, Zhang, Wenjuan, Li, Baoli, Yang, Xi, Mao, Fei, Huang, Jing, Sun, Yi, Li, Jian, Jia, Lijun

Volltext

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Stap... von Ni, Shuaishuai, Wei, Hanwen, Li, Baoli, Chen, Feifei, Liu, Yifu, Chen, Wenhua, Xu, Yixiang, Qiu, Xiaoxia, Li, Xiaokang, Lu, Yanli, Liu, Wenwen, Hu, Linhao, Lin, Dazheng, Wang, Manjiong, Zheng, Xinyu, Mao, Fei, Zhu, Jin, Lan, Lefu, Li, Jian

Volltext

Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infecti... von Wei, Hanwen, Mao, Fei, Ni, Shuaishuai, Chen, Feifei, Li, Baoli, Qiu, Xiaoxia, Hu, Linghao, Wang, Manjiong, Zheng, Xinyu, Zhu, Jin, Lan, Lefu, Li, Jian

Volltext

Bandgap tuning and photocatalytic activities of CuSe1–xSx nanoflakes von Ni, Shuaishuai, Su, Yanjie, Ai, Zhe, Hu, Jing, Yang, Zhi, Kong, Eric Siu-Wai, Zhang, Yafei

Volltext

Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus von Ni, Shuaishuai, Li, Baoli, Chen, Feifei, Wei, Hanwen, Mao, Fei, Liu, Yifu, Xu, Yixiang, Qiu, Xiaoxi, Li, Xiaokang, Liu, Wenwen, Hu, Linghao, Ling, Dazheng, Wang, Manjiong, Zheng, Xinyu, Zhu, Jin, Lan, Lefu, Li, Jian

Volltext

Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections von Li, Baoli, Ni, Shuaishuai, Chen, Feifei, Mao, Fei, Wei, Hanwen, Liu, Yifu, Zhu, Jin, Lan, Lefu, Li, Jian

Volltext

1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: A novel cyclophilin A allosteric activator von Lv, Maosheng, Shi, Ting, Mao, Xiaona, Li, Xi, Chen, Yingyi, Zhu, Jin, Ni, Shuaishuai, Shen, Xu, Jiang, Hualiang, Li, Jian, Zhang, Jian, Huang, Jin

Volltext