Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment von Li, Pengfei, Kim, Yunjeong, Dampalla, Chamandi S, Nhat Nguyen, Harry, Meyerholz, David K, Johnson, David K, Lovell, Scott, Groutas, William C, Perlman, Stanley, Chang, Kyeong-Ok

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Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3CL Protease von Dampalla, Chamandi S, Kim, Yunjeong, Bickmeier, Naemi, Rathnayake, Athri D, Nguyen, Harry Nhat, Zheng, Jian, Kashipathy, Maithri M, Baird, Matthew A, Battaile, Kevin P, Lovell, Scott, Perlman, Stanley, Chang, Kyeong-Ok, Groutas, William C

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Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3C-like Protease von Dampalla, Chamandi S., Rathnayake, Athri D., Galasiti Kankanamalage, Anushka C., Kim, Yunjeong, Perera, Krishani Dinali, Nguyen, Harry Nhat, Miller, Matthew J., Madden, Trent K., Picard, Hunter R., Thurman, Hayden A., Kashipathy, Maithri M., Liu, Lijun, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

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Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease von Damalanka, Vishnu C., Kim, Yunjeong, Galasiti Kankanamalage, Anushka C., Rathnayake, Athri D., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Nguyen, Harry Nhat, Lushington, Gerald H., Chang, Kyeong-Ok, Groutas, William C.

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Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus von Kim, Yunjeong, Pool, Emma, Kim, Eunji, Dampalla, Chamandi S, Nguyen, Harry Nhat, Johnson, David K, Lovell, Scott, Groutas, William C, Chang, Kyeong-Ok

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Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection von Dampalla, Chamandi S., Zheng, Jian, Perera, Krishani Dinali, Wong, Lok-Yin Roy, Meyerholz, David K., Nguyen, Harry Nhat, Kashipathy, Maithri M., Battaile, Kevin P., Lovell, Scott, Kim, Yunjeong, Perlman, Stanley, Groutas, William C., Chang, Kyeong-Ok

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Structure-Guided Design of Potent Inhibitors of SARS-CoV‑2 3CL Protease: Structural, Biochemical, and Cell-Based Studies von Dampalla, Chamandi S, Rathnayake, Athri D, Perera, Krishani Dinali, Jesri, Abdul-Rahman M, Nguyen, Harry Nhat, Miller, Matthew J, Thurman, Hayden A, Zheng, Jian, Kashipathy, Maithri M, Battaile, Kevin P, Lovell, Scott, Perlman, Stanley, Kim, Yunjeong, Groutas, William C, Chang, Kyeong-Ok

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Structure-Guided Design of Potent Coronavirus Inhibitors with a 2‑Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies von Dampalla, Chamandi S., Kim, Yunjeong, Zabiegala, Alexandria, Howard, Dennis J., Nguyen, Harry Nhat, Madden, Trent K., Thurman, Hayden A., Cooper, Anne, Liu, Lijun, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

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Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS... von Dampalla, Chamandi S., Miller, Matthew J., Kim, Yunjeong, Zabiegala, Alexandria, Nguyen, Harry Nhat, Madden, Trent K., Thurman, Hayden A., Machen, Alexandra J., Cooper, Anne, Liu, Lijun, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

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Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS... von Dampalla, Chamandi S., Miller, Matthew J., Kim, Yunjeong, Zabiegala, Alexandria, Nguyen, Harry Nhat, Madden, Trent K., Thurman, Hayden A., Machen, Alexandra J., Cooper, Anne, Liu, Lijun, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

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Structure-guided Design of Conformationally-constrained Cyclohexane Inhibitors of SARS-CoV-2 3CL Protease von Dampalla, Chamandi S., Kim, Yunjeong, Bickmeier, Naemi, Rathnayake, Athri D., Nguyen, Harry Nhat, Zheng, Jian, Kashipathy, Maithri M., Baird, Matthew A., Battaile, Kevin P., Lovell, Scott, Perlman, Stanley, Chang, Kyeong-Ok, Groutas, William C.

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Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease von Rathnayake, Athri D, Kim, Yunjeong, Dampalla, Chamandi S, Nguyen, Harry Nhat, Jesri, Abdul-Rahman M, Kashipathy, Maithri M, Lushington, Gerald H, Battaile, Kevin P, Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C

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Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies von Dampalla, Chamandi S., Nguyen, Harry Nhat, Rathnayake, Athri D., Kim, Yunjeong, Perera, Krishani Dinali, Madden, Trent K., Thurman, Hayden A., Machen, Alexandra J., Kashipathy, Maithri M., Liu, Lijun, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

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Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease von Damalanka, Vishnu C., Kim, Yunjeong, Galasiti Kankanamalage, Anushka C., Rathnayake, Athri D., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Nguyen, Harry Nhat, Lushington, Gerald H., Chang, Kyeong-Ok, Groutas, William C.

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