Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies von Dejanovic, Borislav, Huntley, Melanie A., De Mazière, Ann, Meilandt, William J., Wu, Tiffany, Srinivasan, Karpagam, Jiang, Zhiyu, Gandham, Vineela, Friedman, Brad A., Ngu, Hai, Foreman, Oded, Carano, Richard A.D., Chih, Ben, Klumperman, Judith, Bakalarski, Corey, Hanson, Jesse E., Sheng, Morgan

Volltext

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models von Friedman, Brad A., Srinivasan, Karpagam, Ayalon, Gai, Meilandt, William J., Lin, Han, Huntley, Melanie A., Cao, Yi, Lee, Seung-Hye, Haddick, Patrick C.G., Ngu, Hai, Modrusan, Zora, Larson, Jessica L., Kaminker, Joshua S., van der Brug, Marcel P., Hansen, David V.

Volltext

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mou... von Meilandt, William J, Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J, Stark, Kimberly L, Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A, Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V

Volltext

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy von Wu, Tiffany, Dejanovic, Borislav, Gandham, Vineela D., Gogineni, Alvin, Edmonds, Rose, Schauer, Stephen, Srinivasan, Karpagam, Huntley, Melanie A., Wang, Yuanyuan, Wang, Tzu-Ming, Hedehus, Maj, Barck, Kai H., Stark, Maya, Ngu, Hai, Foreman, Oded, Meilandt, William J., Elstrott, Justin, Chang, Michael C., Hansen, David V., Carano, Richard A.D., Sheng, Morgan, Hanson, Jesse E.

Volltext

Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry von Diao, Jingyu, Pantua, Homer, Ngu, Hai, Komuves, Laszlo, Diehl, Lauri, Schaefer, Gabriele, Kapadia, Sharookh B

Volltext

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer von Lin, WeiYu, Xu, Daqi, Austin, Cary D, Caplazi, Patrick, Senger, Kate, Sun, Yonglian, Jeet, Surinder, Young, Judy, Delarosa, Donnie, Suto, Eric, Huang, Zhiyu, Zhang, Juan, Yan, Donghong, Corzo, Cesar, Barck, Kai, Rajan, Sharmila, Looney, Carrie, Gandham, Vineela, Lesch, Justin, Liang, Wei-Ching, Mai, Elaine, Ngu, Hai, Ratti, Navneet, Chen, Yongmei, Misner, Dinah, Lin, Tori, Danilenko, Dimitry, Katavolos, Paula, Doudemont, Estelle, Uppal, Hirdesh, Eastham, Jeffrey, Mak, Judy, de Almeida, Patricia E, Bao, Katherine, Hadadianpour, Azadeh, Keir, Mary, Carano, Richard A D, Diehl, Lauri, Xu, Min, Wu, Yan, Weimer, Robby M, DeVoss, Jason, Lee, Wyne P, Balazs, Mercedesz, Walsh, Kevin, Alatsis, Kathila R, Martin, Flavius, Zarrin, Ali A

Volltext

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS von Dominguez, Sara, Varfolomeev, Eugene, Brendza, Robert, Stark, Kim, Tea, Joy, Imperio, Jose, Ngu, Hai, Earr, Timothy, Foreman, Oded, Webster, Joshua D., Easton, Amy, Vucic, Domagoj, Bingol, Baris

Volltext

TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice von Wang, Yuanyuan, Wu, Tiffany, Tsai, Ming-Chi, Rezzonico, Mitchell G, Abdel-Haleem, Alyaa M, Xie, Luke, Gandham, Vineela D, Ngu, Hai, Stark, Kimberly, Glock, Caspar, Xu, Daqi, Foreman, Oded, Friedman, Brad A, Sheng, Morgan, Hanson, Jesse E

Volltext

Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display von Nair, Pradeep M., Flores, Heather, Gogineni, Alvin, Marsters, Scot, Lawrence, David A., Kelley, Robert F., Ngu, Hai, Sagolla, Meredith, Komuves, Laszlo, Bourgon, Richard, Settleman, Jeffrey, Ashkenazi, Avi

Volltext

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models von Dejanovic, Borislav, Wu, Tiffany, Tsai, Ming-Chi, Graykowski, David, Gandham, Vineela D, Rose, Christopher M, Bakalarski, Corey E, Ngu, Hai, Wang, Yuanyuan, Pandey, Shristi, Rezzonico, Mitchell G, Friedman, Brad A, Edmonds, Rose, De Mazière, Ann, Rakosi-Schmidt, Raphael, Singh, Tarjinder, Klumperman, Judith, Foreman, Oded, Chang, Michael C, Xie, Luke, Sheng, Morgan, Hanson, Jesse E

Volltext

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors von Merchant, Mark, Moffat, John, Schaefer, Gabriele, Chan, Jocelyn, Wang, Xi, Orr, Christine, Cheng, Jason, Hunsaker, Thomas, Shao, Lily, Wang, Stephanie J, Wagle, Marie-Claire, Lin, Eva, Haverty, Peter M, Shahidi-Latham, Sheerin, Ngu, Hai, Solon, Margaret, Eastham-Anderson, Jeffrey, Koeppen, Hartmut, Huang, Shih-Min A, Schwarz, Jacob, Belvin, Marcia, Kirouac, Daniel, Junttila, Melissa R

Volltext

Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury von Stark, Kimberly, Goncharov, Tatiana, Varfolomeev, Eugene, Xie, Luke, Ngu, Hai, Peng, Ivan, Anderson, Keith R., Verschueren, Erik, Choi, Meena, Kirkpatrick, Donald S., Easton, Amy, Webster, Joshua D., McKenzie, Brent S., Vucic, Domagoj, Bingol, Baris

Volltext

Genetic ablation of Gpnmb does not alter synuclein-related pathology von Brendza, Robert, Lin, Han, Stark, Kimberly, Foreman, Oded, Tao, Janet, Pierce, Andrew, Ngu, Hai, Shen, Kimberle, Easton, Amy E., Bhangale, Tushar, Chang, Diana, Bingol, Baris, Friedman, Brad A.

Volltext

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement von Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded, Chan, Ruby, Ernst, James A., DiCara, Danielle, Hotzel, Isidro, Srinivasan, Karpagam, Hansen, David V., Atwal, Jasvinder, Lu, Yanmei, Bumbaca, Daniela, Pfeifer, Andrea, Watts, Ryan J., Muhs, Andreas, Scearce-Levie, Kimberly, Ayalon, Gai

Volltext

Global proteomics of Ubqln2-based murine models of ALS von Whiteley, Alexandra M., Prado, Miguel A., de Poot, Stefanie A.H., Paulo, Joao A., Ashton, Marissa, Dominguez, Sara, Weber, Martin, Ngu, Hai, Szpyt, John, Jedrychowski, Mark P., Easton, Amy, Gygi, Steven P., Kurz, Thimo, Monteiro, Mervyn J., Brown, Eric J., Finley, Daniel

Volltext

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease von Brendza, Robert, Gao, Xiaoying, Stark, Kimberly L., Lin, Han, Lee, Seung-Hye, Hu, Changyun, Cai, Hao, DiCara, Danielle, Hsiao, Yi-Chun, Ngu, Hai, Foreman, Oded, Baca, Miriam, Dohse, Monika, Fortin, Jean-Phillipe, Corpuz, Racquel, Seshasayee, Dhaya, Easton, Amy, Ayalon, Gai, Hötzel, Isidro, Chih, Ben

Volltext

Mechanical Properties of Actin Stress Fibers in Living Cells von Lu, Lan, Oswald, Sara J., Ngu, Hai, Yin, Frank C.-P.

Volltext

Synthetic Antigen Gels as Practical Controls for Standardized and Quantitative Immunohistochemistry von Hötzel, Kathy J., Havnar, Charles A., Ngu, Hai V., Rost, Sandra, Liu, Scot D., Rangell, Linda K., Peale, Franklin V.

Volltext

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration von Pozniak, Christine D, Sengupta Ghosh, Arundhati, Gogineni, Alvin, Hanson, Jesse E, Lee, Seung-Hye, Larson, Jessica L, Solanoy, Hilda, Bustos, Daisy, Li, Hong, Ngu, Hai, Jubb, Adrian M, Ayalon, Gai, Wu, Jiansheng, Scearce-Levie, Kimberly, Zhou, Qiang, Weimer, Robby M, Kirkpatrick, Donald S, Lewcock, Joseph W

Volltext

Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection von Byrnes, Amy E., Dominguez, Sara L., Yen, Chun-Wan, Laufer, Benjamin I., Foreman, Oded, Reichelt, Mike, Lin, Han, Sagolla, Meredith, Hötzel, Kathy, Ngu, Hai, Soendergaard, Christoffer, Estevez, Alberto, Lin, Hsiu-Chao, Goyon, Alexandre, Bian, Juan, Lin, Jessica, Hinz, Flora I., Friedman, Brad A., Easton, Amy, Hoogenraad, Casper C.

Volltext