Soluble Guanylyl Cyclase Activator BI 685509 Reduces Portal Hypertension and Portosystemic Shunting in a Rat Thioacetamide-Induced Cirrhosis Model von Jones, Amanda K, Chen, Hongxing, Ng, Khing Jow, Villalona, Jorge, McHugh, Mark, Zeveleva, Svetlana, Wilks, James, Brilisauer, Klaus, Bretschneider, Tom, Qian, Hu Sheng, Fryer, Ryan M

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The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease von Reinhart, Glenn A, Harrison, Paul C, Lincoln, Kathleen, Chen, Hongxing, Sun, Peng, Hill, Jon, Qian, Hu Sheng, McHugh, Mark C, Clifford, Holly, Ng, Khing Jow, Wang, Hong, Fowler, Danielle, Gueneva-Boucheva, Kristina, Brenneman, Jehrod B, Bosanac, Todd, Wong, Diane, Fryer, Ryan M, Sarko, Chris, Boustany-Kari, Carine M, Pullen, Steven S

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New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties von Koltun, Dmitry O., Marquart, Timothy A., Shenk, Kevin D., Elzein, Elfatih, Li, Yuan, Nguyen, Marie, Kerwar, Suresh, Zeng, Dewan, Chu, Nancy, Soohoo, Daniel, Hao, Jia, Maydanik, Victoria Y., Lustig, David A., Ng, Khing-Jow, Fraser, Heather, Zablocki, Jeffery A.

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Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection von Tseng, Yin-Chao, Linehan, Brian, Ng, Khing Jow, Smith, Dustin M., Markert, Michael, Patel, Mita, Guth, Brian, Fryer, Ryan M.

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Long-term stability, reproducibility, and statistical sensitivity of a telemetry-instrumented dog model: A 27-month longitudinal assessment von Fryer, Ryan M., Ng, Khing Jow, Chi, Liguo, Jin, Xidong, Reinhart, Glenn A.

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G Protein–Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a K Ca 1.1 (BK Ca )–Dependent Mechanism von Fryer, Ryan M., Ng, Khing Jow, Nodop Mazurek, Suzanne G., Patnaude, Lori, Skow, Donna J., Muthukumarana, Akalushi, Gilpin, Kyle E., Dinallo, Roger M., Kuzmich, Daniel, Lord, John, Sanyal, Sulagna, Yu, Hui, Harcken, Christian, Cerny, Matthew A., Hickey, Eugene R., Modis, Louise K.

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Strategic Integration of In Vivo Cardiovascular Models During Lead Optimization: Predictive Value of 4 Models Independent of Species, Route of Administration, and Influence of Anes... von Fryer, Ryan M, Harrison, Paul C, Muthukumarana, Akalushi, Nodop Mazurek, Suzanne G, Ng, Khing Jow, Chen, Rong Rhonda, Harrington, Kyle E, Dinallo, Roger M, Chi, Liguo, Reinhart, Glenn A

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Effect of hemodynamically-active compounds across anesthetized and conscious cardiovascular models in rat and dog: Correlation with effects in humans von Muthukumarana, Akalushi C., Chen, Rhonda, Mazurek, Suzanne Nodop, Ng, Khing Jow, Reinhart, Glenn A., Harrison, Paul C., Fryer, Ryan M.

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G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism von Fryer, Ryan M, Ng, Khing Jow, Nodop Mazurek, Suzanne G, Patnaude, Lori, Skow, Donna J, Muthukumarana, Akalushi, Gilpin, Kyle E, Dinallo, Roger M, Kuzmich, Daniel, Lord, John, Sanyal, Sulagna, Yu, Hui, Harcken, Christian, Cerny, Matthew A, Cerny, Matthew C, Hickey, Eugene R, Modis, Louise K

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