Biosynthesis of Cholesterol and Other Sterols von Nes, W. David

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Unearthing the Janus-face cholesterogenesis pathways in cancer von Madan, Babita, Virshup, David M., Nes, W. David, Leaver, David J.

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Both methylerythritol phosphate and mevalonate pathways contribute to biosynthesis of each of the major isoprenoid classes in young cotton seedlings von Opitz, Stefan, Nes, W. David, Gershenzon, Jonathan

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Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells von Santori, Fabio R., Huang, Pengxiang, van de Pavert, Serge A., Douglass, Eugene F., Leaver, David J., Haubrich, Brad A., Keber, Rok, Lorbek, Gregor, Konijn, Tanja, Rosales, Brittany N., Rozman, Damjana, Horvat, Simon, Rahier, Alain, Mebius, Reina E., Rastinejad, Fraydoon, Nes, W. David, Littman, Dan R.

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Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri von Zhou, Wenxu, Debnath, Anjan, Jennings, Gareth, Hahn, Hye Jee, Vanderloop, Boden H, Chaudhuri, Minu, Nes, W David, Podust, Larissa M

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A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity[S] von Zhou, Wenxu, Fisher, Paxtyn M., Vanderloop, Boden H., Shen, Yun, Shi, Huazhong, Maldonado, Adrian J., Leaver, David J., Nes, W. David

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Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design von Kidane, Medhanie E., Vanderloop, Boden H., Zhou, Wenxu, Thomas, Crista D., Ramos, Emilio, Singha, Ujjal, Chaudhuri, Minu, Nes, W. David

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Steroidal Antimetabolites Protect Mice against Trypanosoma brucei von Chaudhuri, Minu, Singha, Ujjal K, Vanderloop, Boden H, Tripathi, Anuj, Nes, W David

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CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM) von Debnath, Anjan, Calvet, Claudia M, Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R, Abagyan, Ruben, Nes, W David, McKerrow, James H, Podust, Larissa M

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Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads von Nes, W David, Chaudhuri, Minu, Leaver, David J

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Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51 von Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Fisher, Paxtyn M., Child, Stella A., Nes, W. David, Guengerich, F. Peter, Waterman, Michael R., Lepesheva, Galina I.

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Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications von Zhou, Wenxu, Ramos, Emilio, Zhu, Xunlu, Fisher, Paxtyn M., Kidane, Medhanie E., Vanderloop, Boden H., Thomas, Crista D., Yan, Juqiang, Singha, Ujjal, Chaudhuri, Minu, Nagel, Michael T., Nes, W.David

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Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol von Hargrove, Tatiana Y., Wawrzak, Zdzislaw, Liu, Jialin, Waterman, Michael R., Nes, W. David, Lepesheva, Galina I.

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24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei von Miller, Matthew B., Patkar, Presheet, Singha, Ujjal K., Chaudhuri, Minu, David Nes, W.

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Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S] von Haubrich, Brad A., Singha, Ujjal K., Miller, Matthew B., Nes, Craigen R., Anyatonwu, Hosanna, Lecordier, Laurence, Patkar, Presheet, Leaver, David J., Villalta, Fernando, Vanhollebeke, Benoit, Chaudhuri, Minu, Nes, W. David

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Mechanism of Binding of Prothioconazole to Mycosphaerella graminicola CYP51 Differs from That of Other Azole Antifungals von Parker, Josie E, Warrilow, Andrew G.S, Cools, Hans J, Martel, Claire M, Nes, W. David, Fraaije, Bart A, Lucas, John A, Kelly, Diane E, Kelly, Steven L

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Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51) von WARRILOW, Andrew G. S, MARTEL, Claire M, PARKER, Josie E, MELO, Nadja, LAMB, David C, NES, W. David, KELLY, Diane E, KELLY, Steven L

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Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B von WARRILOW, Andrew G. S, MELO, Nadja, MARTEL, Claire M, PARKER, Josie E, NES, W. David, KELLY, Steven L, KELLY, Diane E

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Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms von Nes, Craigen R, Singha, Ujjal K, Liu, Jialin, Ganapathy, Kulothungan, Villalta, Fernando, Waterman, Michael R, Lepesheva, Galina I, Chaudhuri, Minu, Nes, W David

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Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage von Haubrich, Brad A., Collins, Emily K., Howard, Alicia L., Wang, Qian, Snell, William J., Miller, Matthew B., Thomas, Crista D., Pleasant, Stephanie K., Nes, W. David

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