Oncogenic protein interfaces: small molecules, big challenges von Nero, Tracy L., Morton, Craig J., Holien, Jessica K., Wielens, Jerome, Parker, Michael W.

Volltext

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites von Braig, David, Nero, Tracy L., Koch, Hans-Georg, Kaiser, Benedict, Wang, Xiaowei, Thiele, Jan R., Morton, Craig J., Zeller, Johannes, Kiefer, Jurij, Potempa, Lawrence A., Mellett, Natalie A., Miles, Luke A., Du, Xiao-Jun, Meikle, Peter J., Huber-Lang, Markus, Stark, G. Björn, Parker, Michael W., Peter, Karlheinz, Eisenhardt, Steffen U.

Volltext

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling von Broughton, Sophie E., Dhagat, Urmi, Hercus, Timothy R., Nero, Tracy L., Grimbaldeston, Michele A., Bonder, Claudine S., Lopez, Angel F., Parker, Michael W.

Volltext

C-reactive protein, immunothrombosis and venous thromboembolism von Dix, Caroline, Zeller, Johannes, Stevens, Hannah, Eisenhardt, Steffen U., Shing, Karen S. Cheung Tung, Nero, Tracy L., Morton, Craig J., Parker, Michael W., Peter, Karlheinz, McFadyen, James D.

Volltext

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling von Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dottore, Mara, McClure, Barbara J., Dhagat, Urmi, Taing, Houng, Gorman, Michael A., King-Scott, Jack, Lopez, Angel F., Parker, Michael W.

Volltext

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators von Flierl, Ulrike, Nero, Tracy L, Lim, Bock, Arthur, Jane F, Yao, Yu, Jung, Stephanie M, Gitz, Eelo, Pollitt, Alice Y, Zaldivia, Maria T K, Jandrot-Perrus, Martine, Schäfer, Andreas, Nieswandt, Bernhard, Andrews, Robert K, Parker, Michael W, Gardiner, Elizabeth E, Peter, Karlheinz

Volltext

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein von Zeller, Johannes, Cheung Tung Shing, Karen S, Nero, Tracy L, McFadyen, James D, Krippner, Guy, Bogner, Balázs, Kreuzaler, Sheena, Kiefer, Jurij, Horner, Verena K, Braig, David, Danish, Habiba, Baratchi, Sara, Fricke, Mark, Wang, Xiaowei, Kather, Michel G, Kammerer, Bernd, Woollard, Kevin J, Sharma, Prerna, Morton, Craig J, Pietersz, Geoffrey, Parker, Michael W, Peter, Karlheinz, Eisenhardt, Steffen U

Volltext

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth von Thilakasiri, Pathum, Huynh, Jennifer, Poh, Ashleigh R, Tan, Chin Wee, Nero, Tracy L, Tran, Kelly, Parslow, Adam C, Afshar‐Sterle, Shoukat, Baloyan, David, Hannan, Natalie J, Buchert, Michael, Scott, Andrew Mark, Griffin, Michael DW, Hollande, Frederic, Parker, Michael W, Putoczki, Tracy L, Ernst, Matthias, Chand, Ashwini L

Volltext

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling von Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Kan, Winnie L., Barry, Emma F., Dottore, Mara, Cheung Tung Shing, Karen S., Morton, Craig J., Dhagat, Urmi, Hardy, Matthew P., Wilson, Nicholas J., Downton, Matthew T., Schieber, Christine, Hughes, Timothy P., Lopez, Angel F., Parker, Michael W.

Volltext

Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer von Dmello, Rhynelle S., Palmieri, Michelle, Thilakasiri, Pathum S., Doughty, Larissa, Nero, Tracy L., Poh, Ashleigh R., To, Sarah Q., Lee, Erinna F., Douglas Fairlie, W., Mielke, Lisa, Parker, Michael W., Poon, Ivan K. H., Batlle, Eduard, Ernst, Matthias, Chand, Ashwini L.

Volltext

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis von Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.

Volltext

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody von Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

Volltext

Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities von Singh, Harmeet, Nero, Tracy L, Wang, Yao, Parker, Michael W, Nie, Guiying

Volltext

Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma von Seneviratne, Janith A., Ravindrarajah, Daenikka, Carter, Daniel R., Zhai, Vicki, Lalwani, Amit, Krishan, Sukriti, Balachandran, Anushree, Ng, Ernest, Pandher, Ruby, Wong, Matthew, Nero, Tracy L., Wang, Shudong, Norris, Murray D., Haber, Michelle, Liu, Tao, Parker, Michael W., Cheung, Belamy B., Marshall, Glenn M.

Volltext

Characterization of pathogenic human monoclonal autoantibodies against GM-CSF von Wang, Yanni, Thomson, Christy A., Allan, Lenka L., Jackson, Linda M., Olson, Melanie, Hercus, Timothy R., Nero, Tracy L., Turner, Amanda, Parker, Michael W., Lopez, Angel L., Waddell, Thomas K., Anderson, Gary P., Hamilton, John A., Schrader, John W.

Volltext

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription von Thomas, Daniel, Powell, Jason A., Vergez, Francois, Segal, David H., Nguyen, Nhu-Y.N., Baker, Adele, Teh, Tse-Chieh, Barry, Emma F., Sarry, Jean-Emmanuel, Lee, Erwin M., Nero, Tracy L., Jabbour, Anissa M., Pomilio, Giovanna, Green, Benjamin D., Manenti, Stéphane, Glaser, Stefan P., Parker, Michael W., Lopez, Angel F., Ekert, Paul G., Lock, Richard B., Huang, David C.S., Nilsson, Susie K., Récher, Christian, Wei, Andrew H., Guthridge, Mark A.

Volltext

Evaluating the benefits of renin-angiotensin system inhibitors as cancer treatments von Perini, Marcos V., Dmello, Rhynelle S., Nero, Tracy L., Chand, Ashwini L.

Volltext

Repurposing of drugs as STAT3 inhibitors for cancer therapy von Thilakasiri, Pathum S., Dmello, Rhynelle S., Nero, Tracy L., Parker, Michael W., Ernst, Matthias, Chand, Ashwini L.

Volltext

Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia von Morrow, Marisa R, Batchuluun, Battsetseg, Wu, Jianhan, Ahmadi, Elham, Leroux, Julie M, Mohammadi-Shemirani, Pedrum, Desjardins, Eric M, Wang, Zhichao, Tsakiridis, Evangelia E, Lavoie, Declan C T, Reihani, Amir, Smith, Brennan K, Kwiecien, Jacek M, Lally, James S V, Nero, Tracy L, Parker, Michael W, Ask, Kjetil, Scott, John W, Jiang, Lei, Paré, Guillaume, Pinkosky, Stephen L, Steinberg, Gregory R

Volltext

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA von Ascher, David B., Wielens, Jerome, Nero, Tracy L., Doughty, Larissa, Morton, Craig J., Parker, Michael W.

Volltext