Managing the challenge of chemically reactive metabolites in drug development von Park, B. Kevin, Boobis, Alan, Clarke, Stephen, Goldring, Chris E. P., Jones, David, Kenna, J. Gerry, Lambert, Craig, Laverty, Hugh G., Naisbitt, Dean J., Nelson, Sidney, Nicoll-Griffith, Deborah A., Obach, R. Scott, Routledge, Philip, Smith, Dennis A., Tweedie, Donald J., Vermeulen, Nico, Williams, Dominic P., Wilson, Ian D., Baillie, Thomas A.

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High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry von Wen, Bo, Ma, Li, Nelson, Sidney D, Zhu, Mingshe

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Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib von Teng, Woon Chien, Oh, Jing Wen, New, Lee Sun, Wahlin, Michelle D., Nelson, Sidney D., Ho, Han Kiat, Chan, Eric Chun Yong

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An Inducible Cytochrome P450 3A4-Dependent Vitamin D Catabolic Pathway von Wang, Zhican, Lin, Yvonne S., Zheng, Xi Emily, Senn, Tauri, Hashizume, Takanori, Scian, Michele, Dickmann, Leslie J., Nelson, Sidney D., Baillie, Thomas A., Hebert, Mary F., Blough, David, Davis, Connie L., Thummel, Kenneth E.

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The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4 von Roberts, Arthur G, Yang, Jing, Halpert, James R, Nelson, Sidney D, Thummel, Kenneth T, Atkins, William M

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Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer von Kyriakides, Michael, Maitre, Lea, Stamper, Brendan D., Mohar, Isaac, Kavanagh, Terrance J., Foster, John, Wilson, Ian D., Holmes, Elaine, Nelson, Sidney D., Coen, Muireann

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Rearrangement reactions catalyzed by cytochrome P450s von Ortiz de Montellano, Paul R., Nelson, Sidney D.

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Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells von Hardy, Klarissa D, Wahlin, Michelle D, Papageorgiou, Ioannis, Unadkat, Jashvant D, Rettie, Allan E, Nelson, Sidney D

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Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9 von Rademacher, Peter M, Woods, Caleb M, Huang, Qingbiao, Szklarz, Grazyna D, Nelson, Sidney D

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Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib von Takakusa, Hideo, Wahlin, Michelle D., Zhao, Chunsheng, Hanson, Kelsey L., New, Lee Sun, Chan, Eric Chun Yong, Nelson, Sidney D.

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Interaction of Lapatinib with Cytochrome P450 3A5 von Chan, Eric Chun Yong, New, Lee Sun, Chua, Teck Beng, Yap, Chun Wei, Ho, Han Kiat, Nelson, Sidney D.

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Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats von Khojasteh, S. Cyrus, Oishi, Shimako, Nelson, Sidney D

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Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6 von Mohar, Isaac, Stamper, Brendan D, Rademacher, Peter M, White, Collin C, Nelson, Sidney D, Kavanagh, Terrance J

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Altered secretion patterns and cell wall organization caused by loss of PodB function in the filamentous fungus Aspergillus nidulans von Boppidi, Karthik R., Ribeiro, Liliane Fraga Costa, Iambamrung, Sirasa, Nelson, Sidney M., Wang, Yan, Momany, Michelle, Richardson, Elizabeth A., Lincoln, Stephen, Srivastava, Ranjan, Harris, Steven D., Marten, Mark R.

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Proteomic Analysis of Acetaminophen-Induced Changes in Mitochondrial Protein Expression Using Spectral Counting von Stamper, Brendan D, Mohar, Isaac, Kavanagh, Terrance J, Nelson, Sidney D

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Cross-Linking Mass Spectrometry and Mutagenesis Confirm the Functional Importance of Surface Interactions between CYP3A4 and Holo/Apo Cytochrome b 5 von Zhao, Chunsheng, Gao, Qiuxia, Roberts, Arthur G, Shaffer, Scott A, Doneanu, Catalin E, Xue, Song, Goodlett, David R, Nelson, Sidney D, Atkins, William M

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Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5) von Zhao, Chunsheng, Gao, Qiuxia, Roberts, Arthur G, Shaffer, Scott A, Doneanu, Catalin E, Xue, Song, Goodlett, David R, Nelson, Sidney D, Atkins, William M

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Characterization of Rat Liver Proteins Adducted by Reactive Metabolites of Menthofuran von Khojasteh, S. Cyrus, Hartley, Dylan P, Ford, Kevin A, Uppal, Hirdesh, Oishi, Shimako, Nelson, Sidney D

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Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences von Takakusa, Hideo, Mohar, Isaac, Kavanagh, Terrance J., Kelly, Edward J., Kaspera, Rüdiger, Nelson, Sidney D.

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Multiple-Ligand Binding in CYP2A6: Probing Mechanisms of Cytochrome P450 Cooperativity by Assessing Substrate Dynamics von Harrelson, John P, Atkins, William M, Nelson, Sidney D

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