Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes von Neggers, Jasper Edgar, Kwanten, Bert, Dierckx, Tim, Noguchi, Hiroki, Voet, Arnout, Bral, Lotte, Minner, Kristien, Massant, Bob, Kint, Nicolas, Delforge, Michel, Vercruysse, Thomas, Baloglu, Erkan, Senapedis, William, Jacquemyn, Maarten, Daelemans, Dirk

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Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export von Neggers, Jasper Edgar, Vanstreels, Els, Baloglu, Erkan, Shacham, Sharon, Landesman, Yosef, Daelemans, Dirk

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Target Identification of Small Molecules Using Large-Scale CRISPR–Cas Mutagenesis Scanning of Essential Genes von Kwanten, Bert, Neggers, Jasper Edgar, Daelemans, Dirk

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enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9 von Neggers, Jasper Edgar, Jacquemyn, Maarten, Dierckx, Tim, Kleinstiver, Benjamin Peter, Thibaut, Hendrik Jan, Daelemans, Dirk

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer von Kim, Jimi, McMillan, Elizabeth, Kim, Hyun Seok, Venkateswaran, Niranjan, Makkar, Gurbani, Rodriguez-Canales, Jaime, Villalobos, Pamela, Neggers, Jasper Edgar, Mendiratta, Saurabh, Wei, Shuguang, Landesman, Yosef, Senapedis, William, Baloglu, Erkan, Chow, Chi-Wan B., Frink, Robin E., Gao, Boning, Roth, Michael, Minna, John D., Daelemans, Dirk, Wistuba, Ignacio I., Posner, Bruce A., Scaglioni, Pier Paolo, White, Michael A.

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enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9 von Neggers, Jasper Edgar, Jacquemyn, Maarten, Dierckx, Tim, Kleinstiver, Benjamin Peter, Thibaut, Hendrik Jan, Daelemans, Dirk

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Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export von Neggers, Jasper Edgar, Vanstreels, Els, Baloglu, Erkan, Shacham, Sharon, Landesman, Yosef, Daelemans, Dirk

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Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes von Neggers, Jasper Edgar, Kwanten, Bert, Dierckx, Tim, Noguchi, Hiroki, Voet, Arnout, Bral, Lotte, Minner, Kristien, Massant, Bob, Kint, Nicolas, Delforge, Michel, Vercruysse, Thomas, Baloglu, Erkan, Senapedis, William, Jacquemyn, Maarten, Daelemans, Dirk

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Abstract LB-210: KPT-8602 is a second-generation XPO1 inhibitor with improved in vivo tolerability that demonstrates potent acute lymphoblastic leukemia activity von Daelemans, Dirk, Neggers, Jasper Edgar, De Bie, Jolien, Jacquemyn, Maarten, D’Hoore, Astrid, Vanstreels, Els, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Senapedis, William, Dagklis, Antonis, Vercruysse, Thomas, Cools, Jan

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Target Identification of Small Molecules Using Large-Scale CRISPR-Cas Mutagenesis Scanning of Essential Genes von Kwanten, Bert, Neggers, Jasper Edgar, Daelemans, Dirk

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COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA von PAOLELLA, Brenton, VAZQUEZ, Francisca, NEGGERS, Jasper Edgar, AGUIRRE, Andrew

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COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA von PAOLELLA, Brenton, VAZQUEZ, Francisca, NEGGERS, Jasper Edgar, AGUIRRE, Andrew

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COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA von PAOLELLA, Brenton, VAZQUEZ, Francisca, NEGGERS, Jasper Edgar, AGUIRRE, Andrew

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer von Kim, Jimi, McMillan, Elizabeth, Kim, Hyun Seok, Venkateswaran, Niranjan, Makkar, Gurbani, Rodriguez-Canales, Jaime, Villalobos, Pamela, Neggers, Jasper Edgar, Mendiratta, Saurabh, Wei, Shuguang, Landesman, Yosef, Senapedis, William, Baloglu, Erkan, Chow, Chi-Wan B, Frink, Robin E, Gao, Boning, Roth, Michael, Minna, John D, Daelemans, Dirk, Wistuba, Ignacio I, Posner, Bruce A, Scaglioni, Pier Paolo, White, Michael A

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer von Kim, Jimi, McMillan, Elizabeth, Kim, Hyun Seok, Venkateswaran, Niranjan, Makkar, Gurbani, Rodriguez-Canales, Jaime, Villalobos, Pamela, Neggers, Jasper Edgar, Mendiratta, Saurabh, Wei, Shuguang, Landesman, Yosef, Senapedis, William, Baloglu, Erkan, Chow, Chi-Wan B, Frink, Robin E, Gao, Boning, Roth, Michael, Minna, John D, Daelemans, Dirk, Wistuba, Ignacio I, Posner, Bruce A, Scaglioni, Pier Paolo, White, Michael A

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer von Kim, Jimi, McMillan, Elizabeth, Kim, Hyun Seok, Venkateswaran, Niranjan, Makkar, Gurbani, Rodriguez-Canales, Jaime, Villalobos, Pamela, Neggers, Jasper Edgar, Mendiratta, Saurabh, Wei, Shuguang, Landesman, Yosef, Senapedis, William, Baloglu, Erkan, Chow, Chi-Wan B, Frink, Robin E, Gao, Boning, Roth, Michael, Minna, John D, Daelemans, Dirk, Wistuba, Ignacio I, Posner, Bruce A, Scaglioni, Pier Paolo, White, Michael A

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