Discovery and Optimization of N‑Heteroaryl Indazole LRRK2 Inhibitors von Logan, Kaitlyn M., Kaplan, Will, Simov, Vladimir, Zhou, Hua, Li, Derun, Torres, Luis, Morriello, Gregori J., Acton, John J., Pio, Barbara, Chen, Yi-Heng, Keylor, Mitchell H., Johnson, Rebecca, Kattar, Solomon D., Chau, Ryan, Yan, Xin, Ardolino, Michael, Zarate, Cayetana, Otte, Karin M., Palte, Rachel L., Xiong, Tina, McMinn, Spencer E., Lin, Shishi, Neelamkavil, Santhosh F., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Woodhouse, Janice D., Moy, Lily Y., Ciaccio, Paul J., Piesvaux, Jennifer, Zebisch, Matthias, Henry, Clare, Barker, John, Wood, Harold B., Kennedy, Matthew E., DiMauro, Erin F., Fell, Matthew J., Fuller, Peter H.

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Discovery of MK-8282 as a Potent G‑Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes von Neelamkavil, Santhosh F, Stamford, Andrew W, Kowalski, Timothy, Biswas, Dipshikha, Boyle, Craig, Chackalamannil, Samuel, Xia, Yan, Jayne, Charles, Neustadt, Bernard, Hao, Jinsong, Liu, Hong, Dai, Xing, Baker, Hana, Hawes, Brian, O’Neill, Kim, Tang, Huadong, Greenlee, William J

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Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor von Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth

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The fluorous Swern and Corey–Kim reactions: scope and mechanism von Crich, David, Neelamkavil, Santhosh

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The discovery of azepane sulfonamides as potent 11β-HSD1 inhibitors von Neelamkavil, Santhosh F., Boyle, Craig D., Chackalamannil, Samuel, Greenlee, William J., Zhang, Lili, Terracina, Giuseppe

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Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors von Keylor, Mitchell H, Gulati, Anmol, Kattar, Solomon D, Johnson, Rebecca E, Chau, Ryan W, Margrey, Kaila A, Ardolino, Michael J, Zarate, Cayetana, Poremba, Kelsey E, Simov, Vladimir, Morriello, Gregori J, Acton, John J, Pio, Barbara, Yan, Xin, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Lesburg, Charles A, Adpressa, Donovon, Lin, Shishi, Neelamkavil, Santhosh, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul J, Piesvaux, Jennifer, Otte, Karin M, Wood, Harold B, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease von Candito, David A., Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W., Lapointe, Blair T., Methot, Joey L., DeMong, Duane E., Graham, Thomas H., Kurukulasuriya, Ravi, Keylor, Mitchell H., Tong, Ling, Morriello, Gregori J., Acton, John J., Pio, Barbara, Liu, Weiguo, Scott, Jack D., Ardolino, Michael J., Martinot, Theodore A., Maddess, Matthew L., Yan, Xin, Gunaydin, Hakan, Palte, Rachel L., McMinn, Spencer E., Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C., Lesburg, Charles A., Liu, Ping, Su, Jing, Hegde, Laxminarayan G., Moy, Lily Y., Woodhouse, Janice D., Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A., Otte, Karin M., Kennedy, Matthew E., Bennett, David Jonathan, DiMauro, Erin F., Fell, Matthew J., Neelamkavil, Santhosh, Wood, Harold B., Fuller, Peter H., Ellis, J. Michael

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Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants von Hussain, Zahid, Cooke, Andrew J., Neelamkavil, Santhosh, Brown, Lindsay, Carswell, Emma, Geissler, Wayne M., Guo, Zhuyan, Hawes, Brian, Kelly, Terri M., Kiyoi, Yasuko, Lai, KehDih, Lesburg, Charles, Pow, Eleanor, Zang, Yi, Wood, Harold B., Edmondson, Scott D., Liu, Weiguo

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease von Candito, David A, Simov, Vladimir, Gulati, Anmol, Kattar, Solomon, Chau, Ryan W, Lapointe, Blair T, Methot, Joey L, DeMong, Duane E, Graham, Thomas H, Kurukulasuriya, Ravi, Keylor, Mitchell H, Tong, Ling, Morriello, Gregori J, Acton, John J, Pio, Barbara, Liu, Weiguo, Scott, Jack D, Ardolino, Michael J, Martinot, Theodore A, Maddess, Matthew L, Yan, Xin, Gunaydin, Hakan, Palte, Rachel L, McMinn, Spencer E, Nogle, Lisa, Yu, Hongshi, Minnihan, Ellen C, Lesburg, Charles A, Liu, Ping, Su, Jing, Hegde, Laxminarayan G, Moy, Lily Y, Woodhouse, Janice D, Faltus, Robert, Xiong, Tina, Ciaccio, Paul, Piesvaux, Jennifer A, Otte, Karin M, Kennedy, Matthew E, Bennett, David Jonathan, DiMauro, Erin F, Fell, Matthew J, Neelamkavil, Santhosh, Wood, Harold B, Fuller, Peter H, Ellis, J Michael

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Discovery of hydroxy pyrimidine Factor IXa inhibitors von Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel

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Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors von Velázquez, Francisco, Chelliah, Mariappan, Clasby, Martin, Guo, Zhuyan, Howe, John, Miller, Randy, Neelamkavil, Santhosh, Shah, Unmesh, Soriano, Aileen, Xia, Yan, Venkatraman, Srikanth, Chackalamannil, Samuel, Davies, Ian W

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Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors von Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael

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Fluorous Swern Reaction von Crich, David, Neelamkavil, Santhosh

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Fluorous Dimethyl Sulfide:  A Convenient, Odorless, Recyclable Borane Carrier von Crich, David, Neelamkavil, Santhosh

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Tandem Polar/Radical Crossover Sequences for the Formation of Fused and Bridged Bicyclic Nitrogen Heterocycles Involving Radical Ionic Chain Reactions, and Alkene Radical Cation In... von Crich, David, Ranganathan, Krishnakumar, Neelamkavil, Santhosh, Huang, Xianhai

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Generation and trapping of alkene radical cations under nonoxidizing conditions: formation of six-membered rings by exo- and endo-mode cyclizations von Crich, David, Neelamkavil, Santhosh

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Generation and Trapping of Alkene Radical Cations under Nonoxidizing Conditions:  Formation of Six-Membered Rings by E xo- and E ndo-Mode Cyclizations von Crich, David, Neelamkavil, Santhosh

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Efficient Conversion of Vicinal Diols to Alkenes by Treatment of the Corresponding Dimesylates with a Catalytic, Minimally Fluorous, Recoverable Diaryl Diselenide and Sodium Borohy... von Crich, David, Neelamkavil, Santhosh, Sartillo-Piscil, Fernando

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NK3 MODULATORS AND USES THEREOF von JOSEPH, Scott B, BIFTU, Tesfaye, HE, Shuwen, MOYES, Christopher, NEELAMKAVIL, Santhosh F

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NK3 MODULATORS AND USES THEREOF von JOSEPH, Scott B, BIFTU, Tesfaye, HE, Shuwen, MOYES, Christopher, NEELAMKAVIL, Santhosh F

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