Chaperoning Endoplasmic Reticulum-Associated Degradation (ERAD) and Protein Conformational Diseases von Needham, Patrick G, Guerriero, Christopher J, Brodsky, Jeffrey L

Volltext

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation von Cui, Yixian, Parashar, Smriti, Zahoor, Muhammad, Needham, Patrick G., Mari, Muriel, Zhu, Ming, Chen, Shuliang, Ho, Hsuan-Chung, Reggiori, Fulvio, Farhan, Hesso, Brodsky, Jeffrey L., Ferro-Novick, Susan

Volltext

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43 von Mann, Jacob R., Gleixner, Amanda M., Mauna, Jocelyn C., Gomes, Edward, DeChellis-Marks, Michael R., Needham, Patrick G., Copley, Katie E., Hurtle, Bryan, Portz, Bede, Pyles, Noah J., Guo, Lin, Calder, Christopher B., Wills, Zachary P., Pandey, Udai B., Kofler, Julia K., Brodsky, Jeffrey L., Thathiah, Amantha, Shorter, James, Donnelly, Christopher J.

Volltext

How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: The early history of ERAD von Needham, Patrick G., Brodsky, Jeffrey L.

Volltext

Phage-layer interferometry: a companion diagnostic for phage therapy and a bacterial testing platform von Needham, Patrick, Page, Richard C., Yehl, Kevin

Volltext

SLC26A9 is selected for endoplasmic reticulum associated degradation (ERAD) via Hsp70-dependent targeting of the soluble STAS domain von Needham, Patrick G, Goeckeler-Fried, Jennifer L, Zhang, Casey, Sun, Zhihao, Wetzel, Adam R, Bertrand, Carol A, Brodsky, Jeffrey L

Volltext

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions von Needham, Patrick G., Patel, Hardik J., Chiosis, Gabriela, Thibodeau, Patrick H., Brodsky, Jeffrey L.

Volltext

Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase von Ye, Zhaofeng, Needham, Patrick G., Estabrooks, Samuel K., Whitaker, Susan K., Garcia, Brandon L., Misra, Saurav, Brodsky, Jeffrey L., Camacho, Carlos J.

Volltext

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy von Bhatia, Tarun N., Clark, Rachel N., Needham, Patrick G., Miner, Kristin M., Jamenis, Anuj S., Eckhoff, Elizabeth A., Abraham, Nevil, Hu, Xiaoming, Wipf, Peter, Luk, Kelvin C., Brodsky, Jeffrey L., Leak, Rehana K.

Volltext

Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members von Manos-Turvey, Alexandra, Al-Ashtal, Hiba A., Needham, Patrick G., Hartline, Caroll B., Prichard, Mark N., Wipf, Peter, Brodsky, Jeffrey L.

Volltext

Hsp70 and Hsp90 Multichaperone Complexes Sequentially Regulate Thiazide-sensitive Cotransporter Endoplasmic Reticulum-associated Degradation and Biogenesis von Donnelly, Bridget F., Needham, Patrick G., Snyder, Avin C., Roy, Ankita, Khadem, Shaheen, Brodsky, Jeffrey L., Subramanya, Arohan R.

Volltext

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding von Chiang, Annette N., Liang, Mary, Dominguez-Meijide, Antonio, Masaracchia, Caterina, Goeckeler-Fried, Jennifer L., Mazzone, Carly S., Newhouse, David W., Kendsersky, Nathan M., Yates, Megan E., Manos-Turvey, Alexandra, Needham, Patrick G., Outeiro, Tiago F., Wipf, Peter, Brodsky, Jeffrey L.

Volltext

ESCRT regulates surface expression of the Kir2.1 potassium channel von Kolb, Alexander R, Needham, Patrick G, Rothenberg, Cari, Guerriero, Christopher J, Welling, Paul A, Brodsky, Jeffrey L

Volltext

Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model von Hager, natalie A., Krasowski, Collin J., Mackie, Timothy D., Kolb, Alexander R., Needham, Patrick G., Augustine, Andrew A., Dempsey, Alison, Szent-Gyorgyi, Christopher, Bruchez, Marcel P., Bain, Daniel J., Kwiatkowski, Adam V., O'Donnell, Allyson F., Brodsky, Jeffrey L.

Volltext

The Thiazide-sensitive NaCl Cotransporter Is Targeted for Chaperone-dependent Endoplasmic Reticulum-associated Degradation von Needham, Patrick G., Mikoluk, Kasia, Dhakarwal, Pradeep, Khadem, Shaheen, Snyder, Avin C., Subramanya, Arohan R., Brodsky, Jeffrey L.

Volltext

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock von Botha, Melissa, Chiang, Annette N., Needham, Patrick G., Stephens, Linda L., Hoppe, Heinrich C., Külzer, Simone, Przyborski, Jude M., Lingelbach, Klaus, Wipf, Peter, Brodsky, Jeffrey L., Shonhai, Addmore, Blatch, Gregory L.

Volltext

Loss of Ypk1, the Yeast Homolog to the Human Serum- and Glucocorticoid-induced Protein Kinase, Accelerates Phospholipase B1-mediated Phosphatidylcholine Deacylation von Surlow, Beth A., Cooley, Benjamin M., Needham, Patrick G., Brodsky, Jeffrey L., Patton-Vogt, Jana

Volltext

Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae von Buck, Teresa M, Jordan, Rick, Lyons-Weiler, James, Adelman, Joshua L, Needham, Patrick G, Kleyman, Thomas R, Brodsky, Jeffrey L

Volltext

Prion-impairing mutations in Hsp70 chaperone Ssa1: Effects on ATPase and chaperone activities von Needham, Patrick G., Masison, Daniel C.

Volltext

Social Care in the UK's Four Nations: Between Two Paradigms von Needham, Catherine, Hall, Patrick

Volltext