4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells von Wai, John S, Egbertson, Melissa S, Payne, Linda S, Fisher, Thorsten E, Embrey, Mark W, Tran, Lekhanh O, Melamed, Jeffrey Y, Langford, H. Marie, Guare, James P, Zhuang, Linghang, Grey, Vanessa E, Vacca, Joseph P, Holloway, M. Katharine, Naylor-Olsen, Adel M, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Schleif, William A, Gabryelski, Lori J, Young, Steven D

Volltext

Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter von Tomalia, Donald A., Naylor, Adel M., Goddard III, William A.

Volltext

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile von Duvall, Jeremy R, Bedard, Leanne, Naylor-Olsen, Adel M, Manson, Abigail L, Bittker, Joshua A, Sun, Wenye, Fitzgerald, Mark E, He, Zhenmin, Lee, Maurice D, Marie, Jean-Charles, Muncipinto, Giovanni, Rush, Diane, Xu, Deming, Xu, Huisheng, Zhang, Mingliang, Earl, Ashlee M, Palmer, Michelle A, Foley, Michael A, Vacca, Joseph P, Scherer, Christina A

Volltext

Starburst dendrimers. 5. Molecular shape control von Naylor, Adel M, Goddard, William A, Kiefer, Garry E, Tomalia, Donald A

Volltext

Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors von Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Payne, Linda S., Stauffer, Kenneth J., Williams, Peter D., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., McMasters, Daniel R., Naylor-Olsen, Adel M., Michener, Maria T., Wallace, Audrey A.

Volltext

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position von Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P

Volltext

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates von Sanderson, Philip E. J, Lyle, Terry A, Cutrona, Kellie J, Dyer, Dona L, Dorsey, Bruce D, McDonough, Colleen M, Naylor-Olsen, Adel M, Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J, Cooper, Carolyn M, Gardell, Stephen J, Hare, Timothy R, Krueger, Julie A, Lewis, S. Dale, Lin, Jiunn H, Lucas, Bobby J, Lyle, Elizabeth A, Lynch, Joseph J, Stranieri, Maria T, Vastag, Kari, Yan, Youwei, Shafer, Jules A, Vacca, Joseph P

Volltext

Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles von Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., McMasters, Daniel R., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Kuo, Lawrence C., Yan, Youwei, Lynch, J.J., Lyle, E.A.

Volltext

Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures:  Rapid Structure−Activity Studies by Solid-Phase Synthesis von Lumma, William C, Witherup, Keith M, Tucker, Thomas J, Brady, Steven F, Sisko, John T, Naylor-Olsen, Adel M, Lewis, S. Dale, Lucas, Bobby J, Vacca, Joseph P

Volltext

Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles von Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J.

Volltext

Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist von Duggan, Mark E, Naylor-Olsen, Adel M, Perkins, James J, Anderson, Paul S, Chang, Charles T.-C, Cook, Jacquelynn J, Gould, Robert J, Ihle, Nathan C, Hartman, George D

Volltext

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication... von Brady, Stephen F, Stauffer, Kenneth J, Lumma, William C, Smith, Graham M, Ramjit, Harri G, Lewis, S. Dale, Lucas, Bobby J, Gardell, Steven J, Lyle, Elizabeth A, Appleby, Sandra D, Cook, Jacquelynn J, Holahan, Marie A, Stranieri, Maria T, Lynch, Joseph J, Lin, Jiunn H, Chen, I.-Wu, Vastag, Kari, Naylor-Olsen, Adel M, Vacca, Joseph P

Volltext

Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site von Tucker, Thomas J, Lumma, William C, Mulichak, Anne M, Chen, Zhongguo, Naylor-Olsen, Adel M, Lewis, S. Dale, Lucas, Robert, Freidinger, Roger M, Kuo, Lawrence C

Volltext

Azaindoles: moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors von Sanderson, Philip E.J., Stanton, Matthew G., Dorsey, Bruce D., Lyle, Terry A., McDonough, Colleen, Sanders, William M., Savage, Kelly L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S.Dale, Lucas, Bobby J., Lynch, Joseph J., Yan, Youwei

Volltext

Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position von Feng, Dong-Mei, Gardell, Stephen J, Lewis, S. Dale, Bock, Mark G, Chen, Zhongguo, Freidinger, Roger M, Naylor-Olsen, Adel M, Ramjit, Harri G, Woltmann, Richard, Baskin, Elizabeth P, Lynch, Joseph J, Lucas, Robert, Shafer, Jules A, Dancheck, Kimberley B, Chen, I-Wu, Mao, Shi-Shan, Krueger, Julie A, Hare, Timothy R, Mulichak, Anne M, Vacca, Joseph P

Volltext

Inhibition of thrombin and other trypsin-like serine proteinases by cyclotheonamide A von Lewis, Sidney D., Ng, Assunta S., Baldwin, John J., Fusetani, Nobuhiro, Naylor, Adel M., Shafer, Jules A.

Volltext

3-Amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors von Sanderson, Philip E.J., Cutrona, Kellie J., Savage, Kelly L., Naylor-Olsen, Adel M., Bickel, Denise J., Bohn, Dennis L., Clayton, Franklin C., Krueger, Julie A., Lewis, S.Dale, Lucas, Bobby J., Lyle, Elizabeth A., Wallace, Audrey A., Welsh, Denice C., Yan, Youwei

Volltext

Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P3 Position von Tucker, Thomas J, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Lucas, Bobby J, Sisko, Jack T, Lynch, Joseph J, Lyle, Elizabeth A, Baskin, Elizabeth P, Woltmann, Richard F, Appleby, Sandra D, Chen, I-Wu, Dancheck, Kimberley B, Naylor-Olsen, Adel M, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P

Volltext

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors von Hartman, George D, Egbertson, Melissa S, Halczenko, Wasyl, Laswell, William L, Duggan, Mark E, Smith, Robert L, Naylor, Adel M, Manno, Patricia D, Lynch, Robert J

Volltext

Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp von Egbertson, Melissa S, Chang, Charles T.-C, Duggan, Mark E, Gould, Robert J, Halczenko, Wasyl, Hartman, George D, Laswell, William L, Lynch, Joseph J, Lynch, Robert J

Volltext