IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics von Natesan, Ramakrishnan, Agrawal, Neeraj J.

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Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody von Natesan, Ramakrishnan, Agrawal, Neeraj J.

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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression von Devalaraja, Samir, To, Tsun Ki Jerrick, Folkert, Ian W., Natesan, Ramakrishnan, Alam, Md Zahidul, Li, Minghong, Tada, Yuma, Budagyan, Konstantin, Dang, Mai T., Zhai, Li, Lobel, Graham P., Ciotti, Gabrielle E., Eisinger-Mathason, T.S. Karin, Asangani, Irfan A., Weber, Kristy, Simon, M. Celeste, Haldar, Malay

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Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses von Chen, Jie, Harding, Shane M., Natesan, Ramakrishnan, Tian, Lei, Benci, Joseph L., Li, Weihua, Minn, Andy J., Asangani, Irfan A., Greenberg, Roger A.

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Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19 von Deng, Qu, Rasool, Reyaz ur, Russell, Ronnie M., Natesan, Ramakrishnan, Asangani, Irfan A.

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Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer von Siddiqui, Mohammad Aarif, Gollavilli, Paradesi Naidu, Ramesh, Vignesh, Parma, Beatrice, Schwab, Annemarie, Vazakidou, Maria Eleni, Natesan, Ramakrishnan, Saatci, Ozge, Rapa, Ida, Bironzo, Paolo, Schuhwerk, Harald, Asangani, Irfan Ahmed, Sahin, Ozgur, Volante, Marco, Ceppi, Paolo

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The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter von Gollavilli, Paradesi Naidu, Parma, Beatrice, Siddiqui, Aarif, Yang, Hai, Ramesh, Vignesh, Napoli, Francesca, Schwab, Annemarie, Natesan, Ramakrishnan, Mielenz, Dirk, Asangani, Irfan Ahmed, Brabletz, Thomas, Pilarsky, Christian, Ceppi, Paolo

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EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins von Gollavilli, Paradesi Naidu, Pawar, Aishwarya, Wilder-Romans, Kari, Natesan, Ramakrishnan, Engelke, Carl G, Dommeti, Vijaya L, Krishnamurthy, Pranathi M, Nallasivam, Archana, Apel, Ingrid J, Xu, Tianlei, Qin, Zhaohui S, Feng, Felix Y, Asangani, Irfan A

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Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression von Yuan, Salina, Natesan, Ramakrishnan, Sanchez-Rivera, Francisco J., Li, Jinyang, Bhanu, Natarajan, Yamazoe, Taiji, Lin, Jeffrey H., Merrell, Allyson J., Sela, Yogev, Thomas, Stacy K., Jiang, Yanqing, Plesset, Jacqueline B., Miller, Emma M., Shi, Junwei, Garcia, Benjamin A., Lowe, Scott W., Asangani, Irfan A., Stanger, Ben Z.

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Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance von Rasool, Reyaz ur, O’Connor, Caitlin M., Das, Chandan Kanta, Alhusayan, Mohammed, Verma, Brijesh Kumar, Islam, Sehbanul, Frohner, Ingrid E., Deng, Qu, Mitchell-Velasquez, Erick, Sangodkar, Jaya, Ahmed, Aqila, Linauer, Sarah, Mudrak, Ingrid, Rainey, Jessica, Zawacki, Kaitlin P., Suhan, Tahra K., Callahan, Catherine G., Rebernick, Ryan, Natesan, Ramakrishnan, Siddiqui, Javed, Sauter, Guido, Thomas, Dafydd, Wang, Shaomeng, Taylor, Derek J., Simon, Ronald, Cieslik, Marcin, Chinnaiyan, Arul M., Busino, Luca, Ogris, Egon, Narla, Goutham, Asangani, Irfan A.

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Heterogeneity in Disulfide Bond Reduction in IgG1 Antibodies Is Governed by Solvent Accessibility of the Cysteines von Natesan, Ramakrishnan, Dykstra, Andrew B, Banerjee, Akash, Agrawal, Neeraj J

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Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1 von Deng, Qu, Natesan, Ramakrishnan, Cidre-Aranaz, Florencia, Arif, Shehbeel, Liu, Ying, Rasool, Reyaz ur, Wang, Pei, Mitchell-Velasquez, Erick, Das, Chandan Kanta, Vinca, Endrit, Cramer, Zvi, Grohar, Patrick J., Chou, Margaret, Kumar-Sinha, Chandan, Weber, Kristy, Eisinger-Mathason, T.S. Karin, Grillet, Nicolas, Grünewald, Thomas, Asangani, Irfan A.

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Setd2 inactivation sensitizes lung adenocarcinoma to inhibitors of oxidative respiration and mTORC1 signaling von Walter, David M., Gladstein, Amy C., Doerig, Katherine R., Natesan, Ramakrishnan, Baskaran, Saravana G., Gudiel, A. Andrea, Adler, Keren M., Acosta, Jonuelle O., Wallace, Douglas C., Asangani, Irfan A., Feldser, David M.

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Stochastic model of extracellular vesicle-mediated immunosuppression implicates importance of biophysical parameters in T cell signaling von Ko, Seung-Hyun B., Natesan, Ramakrishnan, Ko, Jina, Radhakrishnan, Ravi

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Abstract S01-01: Therapeutic targeting of TMPRSS2 and ACE2 as a potential strategy to combat COVID-19 von Deng, Qu, Rasool, Reyaz Ur, Natesan, Ramakrishnan, Asangani, Irfan A.

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Active Remodeling of Chromatin and Implications for In Vivo Folding von Natesan, Ramakrishnan, Gowrishankar, Kripa, Kuttippurathu, Lakshmi, Kumar, P. B. Sunil, Rao, Madan

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Toppling the HAT to Treat Lethal Prostate cancer von Rasool, Reyaz Ur, Natesan, Ramakrishnan, Asangani, Irfan A.

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CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation von Rasool, Reyaz Ur, Natesan, Ramakrishnan, Deng, Qu, Aras, Shweta, Lal, Priti, Sander Effron, Samuel, Mitchell-Velasquez, Erick, Posimo, Jessica M, Carskadon, Shannon, Baca, Sylvan C, Pomerantz, Mark M, Siddiqui, Javed, Schwartz, Lauren E, Lee, Daniel J, Palanisamy, Nallasivam, Narla, Goutham, Den, Robert B, Freedman, Matthew L, Brady, Donita C, Asangani, Irfan A

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A Computational Framework to Accurately Predict Enthalpy and Configurational Entropy Landscapes of Multivalent Interactions of Cell Mimetics von Rammohan, Aravind R., Mckenzie, Matthew, Radhakrishnan, Ravi, Ramakrishnan, Natesan

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The role of miR-200b/c in balancing EMT and proliferation revealed by an activity reporter von Gollavilli, Paradesi Naidu, Parma, Beatrice, Siddiqui, Aarif, Yang, Hai, Ramesh, Vignesh, Napoli, Francesca, Schwab, Annemarie, Natesan, Ramakrishnan, Mielenz, Dirk, Asangani, Irfan Ahmed, Brabletz, Thomas, Pilarsky, Christian, Ceppi, Paolo

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