Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19 von Painter, George R, Natchus, Michael G, Cohen, Oren, Holman, Wendy, Painter, Wendy P

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SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 von Wahl, Angela, Gralinski, Lisa E., Johnson, Claire E., Yao, Wenbo, Kovarova, Martina, Dinnon, Kenneth H., Liu, Hongwei, Madden, Victoria J., Krzystek, Halina M., De, Chandrav, White, Kristen K., Gully, Kendra, Schäfer, Alexandra, Zaman, Tanzila, Leist, Sarah R., Grant, Paul O., Bluemling, Gregory R., Kolykhalov, Alexander A., Natchus, Michael G., Askin, Frederic B., Painter, George, Browne, Edward P., Jones, Corbin D., Pickles, Raymond J., Baric, Ralph S., Garcia, J. Victor

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Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity von Cox, Robert M, Sourimant, Julien, Govindarajan, Mugunthan, Natchus, Michael G, Plemper, Richard K

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4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication von Sourimant, Julien, Lieber, Carolin M, Aggarwal, Megha, Cox, Robert M, Wolf, Josef D, Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A, Martinez-Sobrido, Luis, Bluemling, Gregory R, Natchus, Michael G, Painter, George R, Plemper, Richard K

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Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model von Toots, Mart, Yoon, Jeong-Joong, Hart, Michael, Natchus, Michael G., Painter, George R., Plemper, Richard K.

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SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model von Lieber, Carolin M., Cox, Robert M., Sourimant, Julien, Wolf, Josef D., Juergens, Kate, Phung, Quynh, Saindane, Manohar T., Smith, Meghan K., Sticher, Zachary M., Kalykhalov, Alexander A., Natchus, Michael G., Painter, George R., Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.

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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses von Yoon, Jeong-Joong, Toots, Mart, Lee, Sujin, Lee, Myung-Eun, Ludeke, Barbara, Luczo, Jasmina M, Ganti, Ketaki, Cox, Robert M, Sticher, Zachary M, Edpuganti, Vindya, Mitchell, Deborah G, Lockwood, Mark A, Kolykhalov, Alexander A, Greninger, Alexander L, Moore, Martin L, Painter, George R, Lowen, Anice C, Tompkins, Stephen M, Fearns, Rachel, Natchus, Michael G, Plemper, Richard K

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Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance von Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.

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Influenza A virus resistance to 4'-fluorouridine coincides with viral attenuation in vitro and in vivo von Lieber, Carolin M, Kang, Hae-Ji, Aggarwal, Megha, Lieberman, Nicole A, Sobolik, Elizabeth B, Yoon, Jeong-Joong, Natchus, Michael G, Cox, Robert M, Greninger, Alexander L, Plemper, Richard K

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Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance von Agostini, Maria L, Pruijssers, Andrea J, Chappell, James D, Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L, Bluemling, Gregory R, Lockwood, Mark A, Sheahan, Timothy P, Sims, Amy C, Natchus, Michael G, Saindane, Manohar, Kolykhalov, Alexander A, Painter, George R, Baric, Ralph S, Denison, Mark R

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β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome von Urakova, Nadya, Kuznetsova, Valeriya, Crossman, David K, Sokratian, Arpine, Guthrie, David B, Kolykhalov, Alexander A, Lockwood, Mark A, Natchus, Michael G, Crowley, Michael R, Painter, George R, Frolova, Elena I, Frolov, Ilya

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The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection von Painter, George R., Bowen, Richard A., Bluemling, Gregory R., DeBergh, John, Edpuganti, Vindhya, Gruddanti, Prabhakar R., Guthrie, David B., Hager, Michael, Kuiper, Damien L., Lockwood, Mark A., Mitchell, Deborah G., Natchus, Michael G., Sticher, Zachary M., Kolykhalov, Alexander A.

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4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses von Lieber, Carolin M, Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M, Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K, Jones, Cheryl A, Sticher, Zachary M, Kolykhalov, Alexander A, Saindane, Manohar T, Tompkins, Stephen M, Planz, Oliver, Painter, George R, Natchus, Michael G, Sakamoto, Kaori, Plemper, Richard K

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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models von Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Karimi, Amirhossein, Lieberman, Nicole A. P., Sticher, Zachary M., Roychoudhury, Pavitra, Andrews, Meghan K., Krueger, Rebecca E., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A., Greninger, Alexander L., Plemper, Richard K.

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Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets von Cox, Robert M., Wolf, Josef D., Lieberman, Nicole A., Lieber, Carolin M., Kang, Hae-Ji, Sticher, Zachary M., Yoon, Jeong-Joong, Andrews, Meghan K., Govindarajan, Mugunthan, Krueger, Rebecca E., Sobolik, Elizabeth B., Natchus, Michael G., Gewirtz, Andrew T., deSwart, Rik L., Kolykhalov, Alexander A., Hekmatyar, Khan, Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.

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Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding von Wittwer, Kevin, Anderson, Danielle E., Pfeffermann, Kristin, Cox, Robert M., Wolf, Josef D., Santibanez, Sabine, Mankertz, Annette, Plesker, Roland, Sticher, Zachary M., Kolkykhalov, Alexander A., Natchus, Michael G., Pfaller, Christian K., Plemper, Richard K., von Messling, Veronika

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Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function von Sticher, Zachary M, Lu, Gaofei, Mitchell, Deborah G, Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R, Guthrie, David B, Natchus, Michael G, Painter, George R, Kolykhalov, Alexander A

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4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo von Yin, Peiqi, May, Nicholas A, Lello, Laura Sandra, Fayed, Atef, Parks, M Guston, Drobish, Adam M, Wang, Sainan, Andrews, Meghan, Sticher, Zachary, Kolykhalov, Alexander A, Natchus, Michael G, Painter, George R, Merits, Andres, Kielian, Margaret, Morrison, Thomas E

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Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine von Westover, Jonna B, Jung, Kie Hoon, Alkan, Cigdem, Boardman, Kirsten M, Van Wettere, Arnaud J, Martens, Craig, Rojas, Inioska, Hicks, Philip, Thomas, Aaron J, Saindane, Manohar T, Bluemling, Gregory R, Mao, Shuli, Kolykhalov, Alexander A, Natchus, Michael G, Bates, Paul, Painter, George R, Ikegami, Tetsuro, Gowen, Brian B

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The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection von Bluemling, Gregory R., Mao, Shuli, Natchus, Michael G., Painter, Wendy, Mulangu, Sabue, Lockwood, Mark, De La Rosa, Abel, Brasel, Trevor, Comer, Jason E., Freiberg, Alexander N., Kolykhalov, Alexander A., Painter, George R.

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