Mechanisms and optimization of in vivo delivery of lipophilic siRNAs von Stoffel, Markus, Wolfrum, Christian, Shi, Shuanping, Jayaprakash, K Narayanannair, Jayaraman, Muthusamy, Wang, Gang, Pandey, Rajendra K, Rajeev, Kallanthottathil G, Nakayama, Tomoko, Charrise, Klaus, Ndungo, Esther M, Zimmermann, Tracy, Koteliansky, Victor, Manoharan, Muthiah

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics von Anderson, Daniel G, Akinc, Akin, Zumbuehl, Andreas, Goldberg, Michael, Leshchiner, Elizaveta S, Busini, Valentina, Hossain, Naushad, Bacallado, Sergio A, Nguyen, David N, Fuller, Jason, Alvarez, Rene, Borodovsky, Anna, Borland, Todd, Constien, Rainer, de Fougerolles, Antonin, Dorkin, J Robert, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, John, Matthias, Koteliansky, Victor, Manoharan, Muthiah, Nechev, Lubomir, Qin, June, Racie, Timothy, Raitcheva, Denitza, Rajeev, Kallanthottathil G, Sah, Dinah W Y, Soutschek, Jürgen, Toudjarska, Ivanka, Vornlocher, Hans-Peter, Zimmermann, Tracy S, Langer, Robert

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo von Jayaraman, Muthusamy, Ansell, Steven M., Mui, Barbara L., Tam, Ying K., Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K., Rajeev, Kallanthottathil G., Hafez, Ismail M., Akinc, Akin, Maier, Martin A., Tracy, Mark A., Cullis, Pieter R., Madden, Thomas D., Manoharan, Muthiah, Hope, Michael J.

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Versatile Site-Specific Conjugation of Small Molecules to siRNA Using Click Chemistry von Yamada, Takeshi, Peng, Chang Geng, Matsuda, Shigeo, Addepalli, Haripriya, Jayaprakash, K. Narayanannair, Alam, Md. Rowshon, Mills, Kathy, Maier, Martin A, Charisse, Klaus, Sekine, Mitsuo, Manoharan, Muthiah, Rajeev, Kallanthottathil G

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Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles von Mui, Barbara L, Tam, Ying K, Jayaraman, Muthusamy, Ansell, Steven M, Du, Xinyao, Tam, Yuen Yi C, Lin, Paulo JC, Chen, Sam, Narayanannair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Akinc, Akin, Maier, Martin A, Cullis, Pieter, Madden, Thomas D, Hope, Michael J

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Branched Multifunctional Polyether Polyketals: Variation of Ketal Group Structure Enables Unprecedented Control over Polymer Degradation in Solution and within Cells von Shenoi, Rajesh A, Narayanannair, Jayaprakash K, Hamilton, Jasmine L, Lai, Benjamin F. L, Horte, Sonja, Kainthan, Rajesh K, Varghese, Jos P, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Kizhakkedathu, Jayachandran N

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A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development von Severgnini, Mariano, Sherman, Jennifer, Sehgal, Alfica, Jayaprakash, Narayanannair K., Aubin, Justin, Wang, Gang, Zhang, Ligang, Peng, Chang G., Yucius, Kristina, Butler, Jim, Fitzgerald, Kevin

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Allele-Selective Inhibition of Mutant Atrophin‑1 Expression by Duplex and Single-Stranded RNAs von Hu, Jiaxin, Liu, Jing, Narayanannair, K. Jayaprakash, Lackey, Jeremy G, Kuchimanchi, Satya, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Swayze, Eric E, Lima, Walt F, Prakash, Thazha P, Xiang, Qin, Martinez, Carlos, Corey, David R

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Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells von Novobrantseva, Tatiana I, Borodovsky, Anna, Wong, Jamie, Klebanov, Boris, Zafari, Mohammad, Yucius, Kristina, Querbes, William, Ge, Pei, Ruda, Vera M, Milstein, Stuart, Speciner, Lauren, Duncan, Rick, Barros, Scott, Basha, Genc, Cullis, Pieter, Akinc, Akin, Donahoe, Jessica S, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, Bogorad, Roman L, Love, Kevin, Whitehead, Katie, Levins, Chris, Manoharan, Muthiah, Swirski, Filip K, Weissleder, Ralph, Langer, Robert, Anderson, Daniel G, de Fougerolles, Antonin, Nahrendorf, Matthias, Koteliansky, Victor

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Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms von Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Cantley, William L, Dorkin, J Robert, Butler, James S, Qin, LiuLiang, Racie, Timothy, Sprague, Andrew, Fava, Eugenio, Zeigerer, Anja, Hope, Michael J, Zerial, Marino, Sah, Dinah WY, Fitzgerald, Kevin, Tracy, Mark A, Manoharan, Muthiah, Koteliansky, Victor, Fougerolles, Antonin de, Maier, Martin A

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Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver von Akinc, Akin, Goldberg, Michael, Qin, June, Dorkin, J Robert, Gamba-Vitalo, Christina, Maier, Martin, Jayaprakash, K Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Koteliansky, Victor, Röhl, Ingo, Leshchiner, Elizaveta S, Langer, Robert, Anderson, Daniel G

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RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression von Liu, Jing, Pendergraff, Hannah, Narayanannair, K Jayaprakash, Lackey, Jeremy G, Kuchimanchi, Satya, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Hu, Jiaxin, Corey, David R

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Modulation of thermal stability can enhance the potency of siRNA von Addepalli, Haripriya, Meena, Peng, Chang G, Wang, Gang, Fan, Yupeng, Charisse, Klaus, Jayaprakash, K Narayanannair, Rajeev, Kallanthottathil G, Pandey, Rajendra K, Lavine, Gary, Zhang, Ligang, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Manoharan, Muthiah, Maier, Martin A

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates von Frank-Kamenetsky, Maria, Grefhorst, Aldo, Anderson, Norma N, Racie, Timothy S, Bramlage, Birgit, Akinc, Akin, Butler, David, Charisse, Klaus, Dorkin, Robert, Fan, Yupeng, Gamba-Vitalo, Christina, Hadwiger, Philipp, Jayaraman, Muthusamy, John, Matthias, Jayaprakash, K. Narayanannair, Maier, Martin, Nechev, Lubomir, Rajeev, Kallanthottathil G, Read, Timothy, Röhl, Ingo, Soutschek, Jürgen, Tan, Pamela, Wong, Jamie, Wang, Gang, Zimmermann, Tracy, de Fougerolles, Antonin, Vornlocher, Hans-Peter, Langer, Robert, Anderson, Daniel G, Manoharan, Muthiah, Koteliansky, Victor, Horton, Jay D, Fitzgerald, Kevin

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo von Jayaraman, Muthusamy, Ansell, Steven M., Mui, Barbara L., Tam, Ying K., Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K., Rajeev, Kallanthottathil G., Hafez, Ismail M., Akinc, Akin, Maier, Martin A., Tracy, Mark A., Cullis, Pieter R., Madden, Thomas D., Manoharan, Muthiah, Hope, Michael J.

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing InVivo von Jayaraman, Muthusamy, Ansell, Steven M, Mui, Barbara L, Tam, Ying K, Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K, Rajeev, Kallanthottathil G, Hafez, Ismail M, Akinc, Akin, Maier, Martin A, Tracy, Mark A, Cullis, Pieter R, Madden, Thomas D, Manoharan, Muthiah, Hope, Michael J

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CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES von NARAYANANNAIR, Jayaprakash K, MANOHARAN, Muthiah, MAIER, Martin, RAJEEV, Kallanthottathil G

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CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES von NARAYANANNAIR, Jayaprakash K, MANOHARAN, Muthiah, RAJEEV, Kallanthottathil, G, MAIER, Martin

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CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES von NARAYANANNAIR, Jayaprakash K, MANOHARAN, Muthiah, MAIER, Martin, RAJEEV, Kallanthottathil G

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CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES von NARAYANANNAIR, Jayaprakash K, MANOHARAN, Muthiah, RAJEEV, Kallanthottathil, G, MAIER, Martin

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