Discovery of 3‑Benzyl-1‑(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors von Ito, Masahiro, Tanaka, Toshio, Toita, Akinori, Uchiyama, Noriko, Kokubo, Hironori, Morishita, Nao, Klein, Michael G, Zou, Hua, Murakami, Morio, Kondo, Mitsuyo, Sameshima, Tomoya, Araki, Shinsuke, Endo, Satoshi, Kawamoto, Tomohiro, Morin, Gregg B, Aparicio, Samuel A, Nakanishi, Atsushi, Maezaki, Hironobu, Imaeda, Yasuhiro

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CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor von Funnell, Tyler, Tasaki, Shinya, Oloumi, Arusha, Araki, Shinsuke, Kong, Esther, Yap, Damian, Nakayama, Yusuke, Hughes, Christopher S., Cheng, S.-W. Grace, Tozaki, Hirokazu, Iwatani, Misa, Sasaki, Satoshi, Ohashi, Tomohiro, Miyazaki, Tohru, Morishita, Nao, Morishita, Daisuke, Ogasawara-Shimizu, Mari, Ohori, Momoko, Nakao, Shoichi, Karashima, Masatoshi, Sano, Masaya, Murai, Aiko, Nomura, Toshiyuki, Uchiyama, Noriko, Kawamoto, Tomohiro, Hara, Ryujiro, Nakanishi, Osamu, Shumansky, Karey, Rosner, Jamie, Wan, Adrian, McKinney, Steven, Morin, Gregg B., Nakanishi, Atsushi, Shah, Sohrab, Toyoshiba, Hiroyoshi, Aparicio, Samuel

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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic von Hashimoto, Kentaro, Saito, Bunnai, Miyamoto, Naoki, Oguro, Yuya, Tomita, Daisuke, Shiokawa, Zenyu, Asano, Moriteru, Kakei, Hiroyuki, Taya, Naohiro, Kawasaki, Masanori, Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Yoshida, Sei, Yoshimatsu, Mie, Aoyama, Kazunobu, Kosugi, Yohei, Kojima, Takashi, Morishita, Nao, Dougan, Douglas R, Snell, Gyorgy P, Imamura, Shinichi, Ishikawa, Tomoyasu

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Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists von Asano, Moriteru, Hashimoto, Kentaro, Saito, Bunnai, Shiokawa, Zenyu, Sumi, Hiroyuki, Yabuki, Masato, Yoshimatsu, Mie, Aoyama, Kazunobu, Hamada, Teruki, Morishita, Nao, Dougan, Douglas R., Mol, Clifford D., Yoshida, Sei, Ishikawa, Tomoyasu

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Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b... von Ikeda, Shuhei, Sugiyama, Hideyuki, Tokuhara, Hidekazu, Murakami, Masataka, Nakamura, Minoru, Oguro, Yuya, Aida, Jumpei, Morishita, Nao, Sogabe, Satoshi, Dougan, Douglas R., Gay, Sean C., Qin, Ling, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Kamada, Yusuke, Aoyama, Kazunobu, Kimoto, Kouya, Kamata, Makoto

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Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2H‑benzo[b][1... von Ikeda, Shuhei, Sugiyama, Hideyuki, Tokuhara, Hidekazu, Murakami, Masataka, Nakamura, Minoru, Oguro, Yuya, Aida, Jumpei, Morishita, Nao, Sogabe, Satoshi, Dougan, Douglas R., Gay, Sean C., Qin, Ling, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Kamada, Yusuke, Aoyama, Kazunobu, Kimoto, Kouya, Kamata, Makoto

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Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway von Ikeda, Zenichi, Kamei, Taku, Sasaki, Yusuke, Reynolds, Matthew, Sakai, Nozomu, Yoshikawa, Masato, Tawada, Michiko, Morishita, Nao, Dougan, Douglas R., Chen, Chien-Hung, Levin, Irena, Zou, Hua, Kuno, Masako, Arimura, Naoto, Kikukawa, Yusuke, Kondo, Mitsuyo, Tohyama, Kimio, Sato, Kenjiro

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High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae von Blasco, Benjamin, Jang, Soojin, Terauchi, Hiroki, Kobayashi, Naoki, Suzuki, Shuichi, Akao, Yuichiro, Ochida, Atsuko, Morishita, Nao, Takagi, Terufumi, Nagamiya, Hiroyuki, Suzuki, Yamato, Watanabe, Toshiaki, Lee, Hyunjung, Lee, Sol, Shum, David, Cho, Ahreum, Koh, Dahae, Park, Soonju, Lee, Honggun, Kim, Kideok, Ropponen, Henni-Karoliina, Augusto da Costa, Renata Maria, Dunn, Steven, Ghosh, Sunil, Sjö, Peter, Piddock, Laura J.V.

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Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane... von Shiokawa, Zenyu, Hashimoto, Kentaro, Saito, Bunnai, Oguro, Yuya, Sumi, Hiroyuki, Yabuki, Masato, Yoshimatsu, Mie, Kosugi, Yohei, Debori, Yasuyuki, Morishita, Nao, Dougan, Douglas R., Snell, Gyorgy P., Yoshida, Sei, Ishikawa, Tomoyasu

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High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniaeResearch in context von Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen, Renata Maria Augusto da Costa, Steven Dunn, Sunil Ghosh, Peter Sjö, Laura J.V. Piddock

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From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor von Futatsugi, Kentaro, Mascitti, Vincent, Guimarães, Cristiano R.W., Morishita, Nao, Cai, Cuiman, DeNinno, Michael P., Gao, Hua, Hamilton, Michael D., Hank, Richard, Harris, Anthony R., Kung, Daniel W., Lavergne, Sophie Y., Lefker, Bruce A., Lopaze, Michael G., McClure, Kim F., Munchhof, Michael J., Preville, Cathy, Robinson, Ralph P., Wright, Stephen W., Bonin, Paul D., Cornelius, Peter, Chen, Yue, Kalgutkar, Amit S.

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2P021 Computational Drug Design by Accurate Free Energy Calculations(01B. Protein: Structure & Function,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) von Kokubo, Hironori, Yokota, Akihiro, Morishita, Nao, Okabe, Atsutoshi, Watanabe, Etsurou

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LIGHT SOURCE DEVICE AND PROJECTION DISPLAY APPARATUS von MORISHITA, Nao, YAMASHITA, Takao, YOSHIKAWA, Takamasa

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2P021 高精度自由エネルギー計算によるドラッグデザイン(01B. 蛋白質:構造機能相関,ポスター,第52回日本生物物理学会年会(2014年度))

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Projection display apparatus and method of controlling the same von Tanaka, Teruto, Nishihata, Kyousuke, Morishita, Nao, Akaiwa, Natsumi

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PROJECTION DISPLAY APPARATUS AND METHOD OF CONTROLLING THE SAME von MORISHITA, Nao, NISHIHATA, Kyousuke, AKAIWA, Natsumi, TANAKA, Teruto

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HETEROCYCLIC COMPOUND von Maezaki, Hironobu, Kokubo, Hironori, Fujimoto, Jun, Arikawa, Yasuyoshi, Banno, Hiroshi, Ono, Koji, Sakauchi, Nobuki, Tokuhara, Hidekazu, Mizojiri, Ryo, Morishita, Nao, Imaeda, Yasuhiro, Cary, Douglas Robert, Asano, Moriteru, Ito, Masahiro, Cho, Nobuo, Hirayama, Takaharu, Tanaka, Toshio, Hirata, Yasuhiro, Toita, Akinori

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HETEROCYCLIC COMPOUND von CARY, DOUGLAS, ROBERT, TOITA, AKINORI, TOKUHARA, HIDEKAZU, TANAKA, TOSHIO, FUJIMOTO, JUN, HIRATA, YASUHIRO, MIZOJIRI, RYO, MAEZAKI, HIRONOBU, SAKAUCHI, NOBUKI, MORISHITA, NAO, BANNO, HIROSHI, ARIKAWA, YASUYOSHI, ONO, KOJI, KOKUBO, HIRONORI, ITO, MASAHIRO, CHO, NOBUO, ASANO, MORITERU, IMAEDA, YASUHIRO, HIRAYAMA, TAKAHARU

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HETEROCYCLIC COMPOUND von MAEZAKI Hironobu, TANAKA Toshio, CHO Nobuo, TOKUHARA Hidekazu, KOKUBO Hironori, ITO Masahiro, MORISHITA Nao, HIRAYAMA Takaharu, TOITA Akinori, ASANO Moriteru, BANNO Hiroshi, ARIKAWA Yasuyoshi, CARY Douglas Robert, ONO Koji, SAKAUCHI Nobuki, MIZOJIRI Ryo, IMAEDA Yasuhiro, FUJIMOTO Jun, HIRATA Yasuhiro

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HETEROCYCLIC COMPOUND von MORISHITA, Nao, ONO, Koji, CHO, Nobuo, BANNO, Hiroshi, TOKUHARA, Hidekazu, ARIKAWA, Yasuyoshi, HIRAYAMA, Takaharu, ASANO, Moriteru, IMAEDA, Yasuhiro, FUJIMOTO, Jun, SAKAUCHI, Nobuki, KOKUBO, Hironori, MAEZAKI, Hironobu, MIZOJIRI, Ryo, TOITA, Akinori, ITO, Masahiro, TANAKA, Toshio, CARY, Douglas Robert, HIRATA, Yasuhiro

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