KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo von Najumudeen, Arafath K., Fey, Sigrid K., Millett, Laura M., Ford, Catriona A., Gilroy, Kathryn, Gunduz, Nuray, Ridgway, Rachel A., Anderson, Eve, Strathdee, Douglas, Clark, William, Nixon, Colin, Morton, Jennifer P., Campbell, Andrew D., Sansom, Owen J.

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SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers von Lilja, Johanna, Kaivola, Jasmin, Conway, James R. W., Vuorio, Joni, Parkkola, Hanna, Roivas, Pekka, Dibus, Michal, Chastney, Megan R., Varila, Taru, Jacquemet, Guillaume, Peuhu, Emilia, Wang, Emily, Pentikäinen, Ulla, Martinez D. Posada, Itziar, Hamidi, Hellyeh, Najumudeen, Arafath K., Sansom, Owen J., Barsukov, Igor L., Abankwa, Daniel, Vattulainen, Ilpo, Salmi, Marko, Ivaska, Johanna

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Spatial metabolomics to unravel cellular metabolism von Najumudeen, Arafath K, Vande Voorde, Johan

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Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition von Holt, Amy K, Najumudeen, Arafath K, Collard, Tracey J, Li, Hao, Millett, Laura M, Hoskin, Ashley J, Legge, Danny N, Mortensson, Eleanor M H, Flanagan, Dustin J, Jones, Nicholas, Kollareddy, Madhu, Timms, Penny, Hitchings, Matthew D, Cronin, James, Sansom, Owen J, Williams, Ann C, Vincent, Emma E

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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer von Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.

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Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition von Sharbeen, George, McCarroll, Joshua A, Akerman, Anouschka, Kopecky, Chantal, Youkhana, Janet, Kokkinos, John, Holst, Jeff, Boyer, Cyrille, Erkan, Mert, Goldstein, David, Timpson, Paul, Cox, Thomas R, Pereira, Brooke A, Chitty, Jessica L, Fey, Sigrid K, Najumudeen, Arafath K, Campbell, Andrew D, Sansom, Owen J, Ignacio, Rosa Mistica C, Naim, Stephanie, Liu, Jie, Russia, Nelson, Lee, Julia, Chou, Angela, Johns, Amber, Gill, Anthony J, Gonzales-Aloy, Estrella, Gebski, Val, Guan, Yi Fang, Pajic, Marina, Turner, Nigel, Apte, Minoti V, Davis, Thomas P, Morton, Jennifer P, Haghighi, Koroush S, Kasparian, Jorjina, McLean, Benjamin J, Setargew, Yordanos F, Phillips, Phoebe A

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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia von Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.

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Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ von Kiourtis, Christos, Terradas-Terradas, Maria, Gee, Lucy M., May, Stephanie, Georgakopoulou, Anastasia, Collins, Amy L., O’Sullivan, Eoin D., Baird, David P., Hassan, Mohsin, Shaw, Robin, Tan, Ee Hong, Müller, Miryam, Engelmann, Cornelius, Andreola, Fausto, Hsieh, Ya-Ching, Reed, Lee H., Borthwick, Lee A., Nixon, Colin, Clark, William, Hanson, Peter S., Sumpton, David, Mackay, Gillian, Suzuki, Toshiyasu, Najumudeen, Arafath K., Inman, Gareth J., Campbell, Andrew, Barry, Simon T., Quaglia, Alberto, Morris, Christopher M., LeBeau, Fiona E. N., Sansom, Owen J., Kirschner, Kristina, Jalan, Rajiv, Oakley, Fiona, Bird, Thomas G.

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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia von Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.

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Phenotypic Screening Identifies Protein Synthesis Inhibitors as H‑Ras-Nanocluster-Increasing Tumor Growth Inducers von Najumudeen, Arafath K, Posada, Itziar M. D, Lectez, Benoit, Zhou, Yong, Landor, Sebastian K.-J, Fallarero, Adyary, Vuorela, Pia, Hancock, John, Abankwa, Daniel

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MNK Inhibition Sensitizes KRAS -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression von Knight, John R P, Alexandrou, Constantinos, Skalka, George L, Vlahov, Nikola, Pennel, Kathryn, Officer, Leah, Teodosio, Ana, Kanellos, Georgios, Gay, David M, May-Wilson, Sebastian, Smith, Ewan M, Najumudeen, Arafath K, Gilroy, Kathryn, Ridgway, Rachel A, Flanagan, Dustin J, Smith, Rachael C L, McDonald, Laura, MacKay, Craig, Cheasty, Anne, McArthur, Kerri, Stanway, Emma, Leach, Joshua D, Jackstadt, Rene, Waldron, Joseph A, Campbell, Andrew D, Vlachogiannis, Georgios, Valeri, Nicola, Haigis, Kevin M, Sonenberg, Nahum, Proud, Christopher G, Jones, Neil P, Swarbrick, Martin E, McKinnon, Heather J, Faller, William J, Le Quesne, John, Edwards, Joanne, Willis, Anne E, Bushell, Martin, Sansom, Owen J

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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis von Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.

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Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer von Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., Dunne, Philip D.

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Pathway Level Subtyping Identifies a Slow-Cycling Biological Phenotype Associated with Poor Clinical Outcomes in Colorectal Cancer von Malla, Sudhir B, Byrne, Ryan M, Lafarge, Maxime W, Corry, Shania M, Fisher, Natalie C, Tsantoulis, Petros K, Mills, Megan L, Ridgway, Rachel A, Lannagan, Tamsin R M, Najumudeen, Arafath K, Gilroy, Kathryn L, Amirkhah, Raheleh, Maguire, Sarah L, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L, Sakhnevych, Svetlana, McCooey, Aoife J, Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D, Isella, Claudio, Koelzer, Viktor H, SCORT consortium

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Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer von Malla, Sudhir B, Byrne, Ryan M, Lafarge, Maxime W, Corry, Shania M, Fisher, Natalie C, Tsantoulis, Petros K, Mills, Megan L, Ridgway, Rachel A, Lannagan, Tamsin R.M, Najumudeen, Arafath K, Gilroy, Kathryn L, Amirkhah, Raheleh, Maguire, Sarah L, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L, Sakhnevych, Svetlana, Mccooey, Aoife J, Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D, Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B, Kerr, Emma M, Tejpar, Sabine, Maughan, Timothy S, Lawler, Mark, Campbell, Andrew D, Leedham, Simon J, Koelzer, Viktor H, Sansom, Owen J, Dunne, Philip D

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Abstract A004: KRAS allelic imbalance drives an epithelial MAPK-dependent tumor initiation program that is inefficient in provoking metastasis in colorectal cancer in vivo von Najumudeen, Arafath K., Fey, Sigrid K., Campbell, Andrew D., Sansom, Owen J.

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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia von Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly R, Schenck, Ryan O, Wouters, Valerie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, McCorry, Amy M.B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petros, Huels, David J, Tejpar, Sabine, Sansom, Owen J, Leedham, Simon J

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Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer von Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., Dunne, Philip D.

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Apc-mutant cells deploy Notum to bias clonal competition and drive cancer von Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna, Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Yvonne Jones, E., Ristimäki, Ari, Leedham, Simon, Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.

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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis von Leach, Joshua D.G, Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A, Flanagan, Dustin J, Gilroy, Kathryn, Sphyris, Nathalie, Vazquez, Ester G, Vincent, David F, Faller, William J, Hodder, Michael C, Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K, Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R, Huels, David J, Medema, Jan Paul, Barry, Simon T, Frame, Margaret C, Unciti-Broceta, Asier, Leedham, Simon J, Inman, Gareth J, Jackstadt, Rene, Thompson, Barry J, Campbell, Andrew D, Tejpar, Sabine, Sansom, Owen J

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