Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness von Khare, Shilpi, Nagle, Advait S., Biggart, Agnes, Lai, Yin H., Liang, Fang, Davis, Lauren C., Barnes, S. Whitney, Mathison, Casey J. N., Myburgh, Elmarie, Gao, Mu-Yun, Gillespie, J. Robert, Liu, Xianzhong, Tan, Jocelyn L., Stinson, Monique, Rivera, Ianne C., Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel X. Y., Venable, John D., Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab K., Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy C., Buckner, Frederick S., Rao, Srinivasa P. S., Wen, Ben G., Walker, John R., Tuntland, Tove, Molteni, Valentina, Glynne, Richard J., Supek, Frantisek

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Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis von Nagle, Advait S., Khare, Shilpi, Kumar, Arun Babu, Supek, Frantisek, Buchynskyy, Andriy, Mathison, Casey J. N., Chennamaneni, Naveen Kumar, Pendem, Nagendar, Buckner, Frederick S., Gelb, Michael H., Molteni, Valentina

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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen von Plouffe, David, Brinker, Achim, McNamara, Case, Henson, Kerstin, Kato, Nobutaka, Kuhen, Kelli, Nagle, Advait, Adrián, Francisco, Matzen, Jason T, Anderson, Paul, Nam, Tae-gyu, Gray, Nathanael S, Chatterjee, Arnab, Janes, Jeff, Yan, S. Frank, Trager, Richard, Caldwell, Jeremy S, Schultz, Peter G, Zhou, Yingyao, Winzeler, Elizabeth A

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Cesium Effect:  High Chemoselectivity in Direct N-Alkylation of Amines von Salvatore, Ralph Nicholas, Nagle, Advait S., Jung, Kyung Woon

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Efficient Carbamate Synthesis via a Three-Component Coupling of an Amine, CO2, and Alkyl Halides in the Presence of Cs2CO3 and Tetrabutylammonium Iodide von Salvatore, Ralph N, Shin, Seung Il, Nagle, Advait S, Jung, Kyung Woon

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Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis von Rao, Srinivasa P. S., Lakshminarayana, Suresh B., Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Maeser, Pascal, Mottram, Jeremy C., Barrett, Michael P., Diagana, Thierry T.

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Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility von Kato, Nobutaka, Sakata, Tomoyo, Breton, Ghislain, Le Roch, Karine G, Nagle, Advait, Andersen, Carsten, Bursulaya, Badry, Henson, Kerstin, Johnson, Jeffrey, Kumar, Kota Arun, Marr, Felix, Mason, Daniel, McNamara, Case, Plouffe, David, Ramachandran, Vandana, Spooner, Muriel, Tuntland, Tove, Zhou, Yingyao, Peters, Eric C, Chatterjee, Arnab, Schultz, Peter G, Ward, Gary E, Gray, Nathanael, Harper, Jeffrey, Winzeler, Elizabeth A

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Efficient Cs2CO3-promoted solution and solid phase synthesis of carbonates and carbamates in the presence of TBAI von Salvatore, Ralph N, Chu, Feixia, Nagle, Advait S, Kapxhiu, Elona A, Cross, Richard M, Jung, Kyung Woon

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Cesium Hydroxide Promoted Chemoselective N-Alkylation for the Generally Efficient Synthesis of Secondary Amines von Salvatore, Ralph N, Nagle, Advait S, Schmidt, Shaun E, Jung, Kyung Woon

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Cell-based optimization of novel benzamides as potential antimalarial leads von Wu, Tao, Nagle, Advait, Sakata, Tomoyo, Henson, Kerstin, Borboa, Rachel, Chen, Zhong, Kuhen, Kelli, Plouffe, David, Winzeler, Elizabeth, Adrian, Francisco, Tuntland, Tove, Chang, Jonathan, Simerson, Susan, Howard, Steven, Ek, Jared, Isbell, John, Deng, Xianming, Gray, Nathanael S., Tully, David C., Chatterjee, Arnab K.

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Targeting Plasmodium PI(4)K to eliminate malaria von McNamara, Case W., Lee, Marcus C. S., Lim, Chek Shik, Lim, Siau Hoi, Roland, Jason, Nagle, Advait, Simon, Oliver, Yeung, Bryan K. S., Chatterjee, Arnab K., McCormack, Susan L., Manary, Micah J., Zeeman, Anne-Marie, Dechering, Koen J., Kumar, T. R. Santha, Henrich, Philipp P., Gagaring, Kerstin, Ibanez, Maureen, Kato, Nobutaka, Kuhen, Kelli L., Fischli, Christoph, Rottmann, Matthias, Plouffe, David M., Bursulaya, Badry, Meister, Stephan, Rameh, Lucia, Trappe, Joerg, Haasen, Dorothea, Timmerman, Martijn, Sauerwein, Robert W., Suwanarusk, Rossarin, Russell, Bruce, Renia, Laurent, Nosten, Francois, Tully, David C., Kocken, Clemens H. M., Glynne, Richard J., Bodenreider, Christophe, Fidock, David A., Diagana, Thierry T., Winzeler, Elizabeth A.

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Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases von Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H, Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J, Rao, Srinivasa P. S, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J, Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina

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KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission von Kuhen, Kelli L, Chatterjee, Arnab K, Rottmann, Matthias, Gagaring, Kerstin, Borboa, Rachel, Buenviaje, Jennifer, Chen, Zhong, Francek, Carolyn, Wu, Tao, Nagle, Advait, Barnes, S Whitney, Plouffe, David, Lee, Marcus C S, Fidock, David A, Graumans, Wouter, van de Vegte-Bolmer, Marga, van Gemert, Geert J, Wirjanata, Grennady, Sebayang, Boni, Marfurt, Jutta, Russell, Bruce, Suwanarusk, Rossarin, Price, Ric N, Nosten, Francois, Tungtaeng, Anchalee, Gettayacamin, Montip, Sattabongkot, Jetsumon, Taylor, Jennifer, Walker, John R, Tully, David, Patra, Kailash P, Flannery, Erika L, Vinetz, Joseph M, Renia, Laurent, Sauerwein, Robert W, Winzeler, Elizabeth A, Glynne, Richard J, Diagana, Thierry T

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Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery von Meister, Stephan, Plouffe, David M., Kuhen, Kelli L., Bonamy, Ghislain M. C., Wu, Tao, Barnes, S. Whitney, Bopp, Selina E., Borboa, Rachel, Bright, A. Taylor, Che, Jianwei, Cohen, Steve, Dharia, Neekesh V., Gagaring, Kerstin, Gettayacamin, Montip, Gordon, Perry, Groessl, Todd, Kato, Nobutaka, Lee, Marcus C. S., McNamara, Case W., Fidock, David A., Nagle, Advait, Nam, Tae-gyu, Richmond, Wendy, Roland, Jason, Rottmann, Matthias, Zhou, Bin, Froissard, Patrick, Glynne, Richard J., Mazier, Dominique, Sattabongkot, Jetsumon, Schultz, Peter G., Tuntland, Tove, Walker, John R., Zhou, Yingyao, Chatterjee, Arnab, Diagana, Thierry T., Winzeler, Elizabeth A.

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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum von Vaidya, Akhil B., Morrisey, Joanne M., Zhang, Zhongsheng, Das, Sudipta, Daly, Thomas M., Otto, Thomas D., Spillman, Natalie J., Wyvratt, Matthew, Siegl, Peter, Marfurt, Jutta, Wirjanata, Grennady, Sebayang, Boni F., Price, Ric N., Chatterjee, Arnab, Nagle, Advait, Stasiak, Marcin, Charman, Susan A., Angulo-Barturen, Iñigo, Ferrer, Santiago, Belén Jiménez-Díaz, María, Martínez, María Santos, Gamo, Francisco Javier, Avery, Vicky M., Ruecker, Andrea, Delves, Michael, Kirk, Kiaran, Berriman, Matthew, Kortagere, Sandhya, Burrows, Jeremy, Fan, Erkang, Bergman, Lawrence W.

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Efficient synthesis of β-amino bromides von Nagle, Advait S, Salvatore, Ralph N, Chong, Byong-Don, Woon Jung, Kyung

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Substituted 2‑Phenylimidazopyridines: A New Class of Drug Leads for Human African Trypanosomiasis von Tatipaka, Hari Babu, Gillespie, J. Robert, Chatterjee, Arnab K, Norcross, Neil R, Hulverson, Matthew A, Ranade, Ranae M, Nagendar, Pendem, Creason, Sharon A, McQueen, Joshua, Duster, Nicole A, Nagle, Advait, Supek, Frantisek, Molteni, Valentina, Wenzler, Tanja, Brun, Reto, Glynne, Richard, Buckner, Frederick S, Gelb, Michael H

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Selective mono protection of diols, diamines, and amino alcohols using cesium bases von Nagle, Advait S, Salvatore, Ralph N, Cross, Richard M, Kapxhiu, Elona A, Sahab, Suma, Yoon, Cheol Hwan, Jung, Kyung Woon

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CsOH-promoted chemoselective mono-N-alkylation of diamines and polyamines von Salvatore, Ralph N, Schmidt, Shaun E, Shin, Seung Il, Nagle, Advait S, Worrell, Jay H, Jung, Kyung Woon

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Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility von Winzeler, Elizabeth A, Kato, Nobutaka, Sakata, Tomoyo, Breton, Ghislain, Le Roch, Karine G, Nagle, Advait, Andersen, Carsten, Bursulaya, Badry, Henson, Kerstin, Johnson, Jeffrey, Kumar, Kota Arun, Marr, Felix, Mason, Daniel, McNamara, Case, Plouffe, David, Ramachandran, Vandana, Spooner, Muriel, Tuntland, Tove, Zhou, Yingyao, Peters, Eric C, Chatterjee, Arnab, Schultz, Peter G, Ward, Gary E, Gray, Nathanael, Harper, Jeffrey

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