Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d von Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J., Lotfy, Peter, Wu, Xuebing, Novick, Scott J., Strutzenberg, Timothy, Griffin, Patrick R., Hsu, Patrick D., Lyumkis, Dmitry

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One-step construction of circularized nanodiscs using SpyCatcher-SpyTag von Zhang, Shanwen, Ren, Qian, Novick, Scott J., Strutzenberg, Timothy S., Griffin, Patrick R., Bao, Huan

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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation von Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.

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Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas von Alvizo, Oscar, Nguyen, Luan J., Savile, Christopher K., Bresson, Jamie A., Lakhapatri, Satish L., Solis, Earl O. P., Fox, Richard J., Broering, James M., Benoit, Michael R., Zimmerman, Sabrina A., Novick, Scott J., Liang, Jack, Lalonde, James J.

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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation von Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L

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Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ von Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Novick, Scott J., Blayo, Anne-Laure, Patton, Trey, Mendes, Desiree E., Diaz, Philippe, Kamenecka, Theodore M., Griffin, Patrick R., Hughes, Travis S.

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HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions von Zheng, Jie, Chang, Mi Ra, Stites, Ryan E., Wang, Yong, Bruning, John B., Pascal, Bruce D., Novick, Scott J., Garcia-Ordonez, Ruben D., Stayrook, Keith R., Chalmers, Michael J., Dodge, Jeffrey A., Griffin, Patrick R.

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HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity von Zheng, Jie, Wang, Chen, Chang, Mi Ra, Devarkar, Swapnil C., Schweibenz, Brandon, Crynen, Gogce C., Garcia-Ordonez, Ruben D., Pascal, Bruce D., Novick, Scott J., Patel, Smita S., Marcotrigiano, Joseph, Griffin, Patrick R.

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Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex von Patil, Dipak N, Rangarajan, Erumbi S, Novick, Scott J, Pascal, Bruce D, Kojetin, Douglas J, Griffin, Patrick R, Izard, Tina, Martemyanov, Kirill A

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HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists von Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors von Kim, Hyeonwoo, Wrann, Christiane D., Jedrychowski, Mark, Vidoni, Sara, Kitase, Yukiko, Nagano, Kenichi, Zhou, Chenhe, Chou, Joshua, Parkman, Virginia-Jeni A., Novick, Scott J., Strutzenberg, Timothy S., Pascal, Bruce D., Le, Phuong T., Brooks, Daniel J., Roche, Alexander M., Gerber, Kaitlyn K., Mattheis, Laura, Chen, Wenjing, Tu, Hua, Bouxsein, Mary L., Griffin, Patrick R., Baron, Roland, Rosen, Clifford J., Bonewald, Lynda F., Spiegelman, Bruce M.

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Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia von Cyr, Matthew G, Mhibik, Maissa, Qi, Junpeng, Peng, Haiyong, Chang, Jing, Gaglione, Erika M, Eik, David, Herrick, John, Venables, Thomas, Novick, Scott J, Courouble, Valentine V, Griffin, Patrick R, Wiestner, Adrian, Rader, Christoph

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Engineering an Amine Transaminase for the Efficient Production of a Chiral Sacubitril Precursor von Novick, Scott J, Dellas, Nikki, Garcia, Ravi, Ching, Charlene, Bautista, Abigail, Homan, David, Alvizo, Oscar, Entwistle, David, Kleinbeck, Florian, Schlama, Thierry, Ruch, Thomas

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Structure of an AMPK complex in an inactive, ATP-bound state von Yan, Yan, Mukherjee, Somnath, Harikumar, Kaleeckal G, Strutzenberg, Timothy S, Zhou, X Edward, Suino-Powell, Kelly, Xu, Ting-Hai, Sheldon, Ryan D, Lamp, Jared, Brunzelle, Joseph S, Radziwon, Katarzyna, Ellis, Abigail, Novick, Scott J, Vega, Irving E, Jones, Russell G, Miller, Laurence J, Xu, H Eric, Griffin, Patrick R, Kossiakoff, Anthony A, Melcher, Karsten

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Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex von Patil, Dipak N, Singh, Shikha, Laboute, Thibaut, Strutzenberg, Timothy S, Qiu, Xingyu, Wu, Di, Novick, Scott J, Robinson, Carol V, Griffin, Patrick R, Hunt, John F, Izard, Tina, Singh, Appu K, Martemyanov, Kirill A

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Pharmacological repression of PPARγ promotes osteogenesis von Marciano, David P., Kuruvilla, Dana S., Boregowda, Siddaraju V., Asteian, Alice, Hughes, Travis S., Garcia-Ordonez, Ruben, Corzo, Cesar A., Khan, Tanya M., Novick, Scott J., Park, HaJeung, Kojetin, Douglas J., Phinney, Donald G., Bruning, John B., Kamenecka, Theodore M., Griffin, Patrick R.

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Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states von Yan, Yan, Zhou, X. Edward, Novick, Scott J., Shaw, Simon J., Li, Yingwu, Brunzelle, Joseph S., Hitoshi, Yasumichi, Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors von Kim, Hyeonwoo, Wrann, Christiane D., Jedrychowski, Mark, Vidoni, Sara, Kitase, Yukiko, Nagano, Kenichi, Zhou, Chenhe, Chou, Joshua, Parkman, Virginia-Jeni A., Novick, Scott J., Strutzenberg, Timothy S., Pascal, Bruce D., Le, Phuong T., Brooks, Daniel J., Roche, Alexander M., Gerber, Kaitlyn K., Mattheis, Laura, Chen, Wenjing, Tu, Hua, Bouxsein, Mary L., Griffin, Patrick R., Baron, Roland, Rosen, Clifford J., Bonewald, Lynda F., Spiegelman, Bruce M.

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Stereoselective Reduction of α‑Fluoro-β-ketoesters: Ketoreductases and Dynamic Reductive Kinetic Resolution von Green, Thomas K., Vanagel, Matthew, Damarancha, Anil, Showalter, Brandon, Novick, Scott J., Chagger Maniar, Harvinder

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Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179 von Patil, Dipak N, Pantalone, Serena, Cao, Yan, Laboute, Thibaut, Novick, Scott J, Singh, Shikha, Savino, Simone, Faravelli, Silvia, Magnani, Francesca, Griffin, Patrick R, Singh, Appu K, Forneris, Federico, Martemyanov, Kirill A

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