Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors von Kim, Hyeonwoo, Wrann, Christiane D., Jedrychowski, Mark, Vidoni, Sara, Kitase, Yukiko, Nagano, Kenichi, Zhou, Chenhe, Chou, Joshua, Parkman, Virginia-Jeni A., Novick, Scott J., Strutzenberg, Timothy S., Pascal, Bruce D., Le, Phuong T., Brooks, Daniel J., Roche, Alexander M., Gerber, Kaitlyn K., Mattheis, Laura, Chen, Wenjing, Tu, Hua, Bouxsein, Mary L., Griffin, Patrick R., Baron, Roland, Rosen, Clifford J., Bonewald, Lynda F., Spiegelman, Bruce M.

Volltext

Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas von Alvizo, Oscar, Nguyen, Luan J., Savile, Christopher K., Bresson, Jamie A., Lakhapatri, Satish L., Solis, Earl O. P., Fox, Richard J., Broering, James M., Benoit, Michael R., Zimmerman, Sabrina A., Novick, Scott J., Liang, Jack, Lalonde, James J.

Volltext

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation von Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.

Volltext

One-step construction of circularized nanodiscs using SpyCatcher-SpyTag von Zhang, Shanwen, Ren, Qian, Novick, Scott J., Strutzenberg, Timothy S., Griffin, Patrick R., Bao, Huan

Volltext

Structure of an AMPK complex in an inactive, ATP-bound state von Yan, Yan, Mukherjee, Somnath, Harikumar, Kaleeckal G, Strutzenberg, Timothy S, Zhou, X Edward, Suino-Powell, Kelly, Xu, Ting-Hai, Sheldon, Ryan D, Lamp, Jared, Brunzelle, Joseph S, Radziwon, Katarzyna, Ellis, Abigail, Novick, Scott J, Vega, Irving E, Jones, Russell G, Miller, Laurence J, Xu, H Eric, Griffin, Patrick R, Kossiakoff, Anthony A, Melcher, Karsten

Volltext

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors von Kim, Hyeonwoo, Wrann, Christiane D., Jedrychowski, Mark, Vidoni, Sara, Kitase, Yukiko, Nagano, Kenichi, Zhou, Chenhe, Chou, Joshua, Parkman, Virginia-Jeni A., Novick, Scott J., Strutzenberg, Timothy S., Pascal, Bruce D., Le, Phuong T., Brooks, Daniel J., Roche, Alexander M., Gerber, Kaitlyn K., Mattheis, Laura, Chen, Wenjing, Tu, Hua, Bouxsein, Mary L., Griffin, Patrick R., Baron, Roland, Rosen, Clifford J., Bonewald, Lynda F., Spiegelman, Bruce M.

Volltext

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing von Gu, Xin, Yan, Yan, Novick, Scott J., Kovach, Amanda, Goswami, Devrishi, Ke, Jiyuan, Tan, M. H. Eileen, Wang, Lili, Li, Xiaodan, de Waal, Parker W., Webb, Martin R., Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten

Volltext

Discovery of Hydrolysis-Resistant Isoindoline N‑Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration von Lin, Hua, Long, Jonathan Z, Roche, Alexander M, Svensson, Katrin J, Dou, Florence Y, Chang, Mi Ra, Strutzenberg, Timothy, Ruiz, Claudia, Cameron, Michael D, Novick, Scott J, Berdan, Charles A, Louie, Sharon M, Nomura, Daniel K, Spiegelman, Bruce M, Griffin, Patrick R, Kamenecka, Theodore M

Volltext

Synthetic RORγt Agonists Enhance Protective Immunity von Chang, Mi Ra, Dharmarajan, Venkatasubramanian, Doebelin, Christelle, Garcia-Ordonez, Ruben D, Novick, Scott J, Kuruvilla, Dana S, Kamenecka, Theodore M, Griffin, Patrick R

Volltext

Structure–Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production von Lin, Hua, Sharabi, Kfir, Lin, Li, Ruiz, Claudia, Zhu, Di, Cameron, Michael D, Novick, Scott J, Griffin, Patrick R, Puigserver, Pere, Kamenecka, Theodore M

Volltext

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists von Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R

Volltext

Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay von Shirey, Ryan J., Hart, Jonathan R., Sridharan, BanuPriya, Novick, Scott J., Turner, Lewis D., Zhou, Bin, Nielsen, Alexander L., Eubanks, Lisa M., Ueno, Lynn, Hixon, Mark S., Lairson, Luke L., Spicer, Timothy P., Scampavia, Louis D., Griffin, Patrick R., Vogt, Peter K., Janda, Kim D.

Volltext

Stereoselective Reduction of α‑Fluoro-β-ketoesters: Ketoreductases and Dynamic Reductive Kinetic Resolution von Green, Thomas K., Vanagel, Matthew, Damarancha, Anil, Showalter, Brandon, Novick, Scott J., Chagger Maniar, Harvinder

Volltext

Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia von Cyr, Matthew G, Mhibik, Maissa, Qi, Junpeng, Peng, Haiyong, Chang, Jing, Gaglione, Erika M, Eik, David, Herrick, John, Venables, Thomas, Novick, Scott J, Courouble, Valentine V, Griffin, Patrick R, Wiestner, Adrian, Rader, Christoph

Volltext

Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)‑Licarbazepine Using an Evolved Ketoreductase von Modukuru, Naga K, Sukumaran, Joly, Collier, Steven J, Chan, Ann Shu, Gohel, Anupam, Huisman, Gjalt W, Keledjian, Raquel, Narayanaswamy, Karthik, Novick, Scott J, Palanivel, S. M, Smith, Derek, Wei, Zhang, Wong, Brian, Yeo, Wan Lin, Entwistle, David A

Volltext

HDX-MS reveals structural determinants for ROR[gamma] hyperactivation by synthetic agonists von Strutzenberg, Timothy S, Garcia-Ordonez, Ruben D, Novick, Scott J, Park, HaJeung, Chang, Mi Ra, Doebellin, Christelle, He, Yuanjun, Patouret, Rémi, Kamenecka, Theodore M, Griffin, Patrick R

Volltext

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d von Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J., Lotfy, Peter, Wu, Xuebing, Novick, Scott J., Strutzenberg, Timothy, Griffin, Patrick R., Hsu, Patrick D., Lyumkis, Dmitry

Volltext

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation von Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L

Volltext

Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ von Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Novick, Scott J., Blayo, Anne-Laure, Patton, Trey, Mendes, Desiree E., Diaz, Philippe, Kamenecka, Theodore M., Griffin, Patrick R., Hughes, Travis S.

Volltext

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions von Zheng, Jie, Chang, Mi Ra, Stites, Ryan E., Wang, Yong, Bruning, John B., Pascal, Bruce D., Novick, Scott J., Garcia-Ordonez, Ruben D., Stayrook, Keith R., Chalmers, Michael J., Dodge, Jeffrey A., Griffin, Patrick R.

Volltext