Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d von Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J., Lotfy, Peter, Wu, Xuebing, Novick, Scott J., Strutzenberg, Timothy, Griffin, Patrick R., Hsu, Patrick D., Lyumkis, Dmitry

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors von Kim, Hyeonwoo, Wrann, Christiane D., Jedrychowski, Mark, Vidoni, Sara, Kitase, Yukiko, Nagano, Kenichi, Zhou, Chenhe, Chou, Joshua, Parkman, Virginia-Jeni A., Novick, Scott J., Strutzenberg, Timothy S., Pascal, Bruce D., Le, Phuong T., Brooks, Daniel J., Roche, Alexander M., Gerber, Kaitlyn K., Mattheis, Laura, Chen, Wenjing, Tu, Hua, Bouxsein, Mary L., Griffin, Patrick R., Baron, Roland, Rosen, Clifford J., Bonewald, Lynda F., Spiegelman, Bruce M.

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One-step construction of circularized nanodiscs using SpyCatcher-SpyTag von Zhang, Shanwen, Ren, Qian, Novick, Scott J., Strutzenberg, Timothy S., Griffin, Patrick R., Bao, Huan

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Engineering an Amine Transaminase for the Efficient Production of a Chiral Sacubitril Precursor von Novick, Scott J, Dellas, Nikki, Garcia, Ravi, Ching, Charlene, Bautista, Abigail, Homan, David, Alvizo, Oscar, Entwistle, David, Kleinbeck, Florian, Schlama, Thierry, Ruch, Thomas

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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation von Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.

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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation von Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L

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Directed evolution of an ultrastable carbonic anhydrase for highly efficient carbon capture from flue gas von Alvizo, Oscar, Nguyen, Luan J., Savile, Christopher K., Bresson, Jamie A., Lakhapatri, Satish L., Solis, Earl O. P., Fox, Richard J., Broering, James M., Benoit, Michael R., Zimmerman, Sabrina A., Novick, Scott J., Liang, Jack, Lalonde, James J.

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Structure of an AMPK complex in an inactive, ATP-bound state von Yan, Yan, Mukherjee, Somnath, Harikumar, Kaleeckal G, Strutzenberg, Timothy S, Zhou, X Edward, Suino-Powell, Kelly, Xu, Ting-Hai, Sheldon, Ryan D, Lamp, Jared, Brunzelle, Joseph S, Radziwon, Katarzyna, Ellis, Abigail, Novick, Scott J, Vega, Irving E, Jones, Russell G, Miller, Laurence J, Xu, H Eric, Griffin, Patrick R, Kossiakoff, Anthony A, Melcher, Karsten

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Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex von Patil, Dipak N, Singh, Shikha, Laboute, Thibaut, Strutzenberg, Timothy S, Qiu, Xingyu, Wu, Di, Novick, Scott J, Robinson, Carol V, Griffin, Patrick R, Hunt, John F, Izard, Tina, Singh, Appu K, Martemyanov, Kirill A

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Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ von Heidari, Zahra, Chrisman, Ian M., Nemetchek, Michelle D., Novick, Scott J., Blayo, Anne-Laure, Patton, Trey, Mendes, Desiree E., Diaz, Philippe, Kamenecka, Theodore M., Griffin, Patrick R., Hughes, Travis S.

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HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity von Zheng, Jie, Wang, Chen, Chang, Mi Ra, Devarkar, Swapnil C., Schweibenz, Brandon, Crynen, Gogce C., Garcia-Ordonez, Ruben D., Pascal, Bruce D., Novick, Scott J., Patel, Smita S., Marcotrigiano, Joseph, Griffin, Patrick R.

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HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions von Zheng, Jie, Chang, Mi Ra, Stites, Ryan E., Wang, Yong, Bruning, John B., Pascal, Bruce D., Novick, Scott J., Garcia-Ordonez, Ruben D., Stayrook, Keith R., Chalmers, Michael J., Dodge, Jeffrey A., Griffin, Patrick R.

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Discovery of Hydrolysis-Resistant Isoindoline N‑Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration von Lin, Hua, Long, Jonathan Z, Roche, Alexander M, Svensson, Katrin J, Dou, Florence Y, Chang, Mi Ra, Strutzenberg, Timothy, Ruiz, Claudia, Cameron, Michael D, Novick, Scott J, Berdan, Charles A, Louie, Sharon M, Nomura, Daniel K, Spiegelman, Bruce M, Griffin, Patrick R, Kamenecka, Theodore M

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Pharmacological repression of PPARγ promotes osteogenesis von Marciano, David P., Kuruvilla, Dana S., Boregowda, Siddaraju V., Asteian, Alice, Hughes, Travis S., Garcia-Ordonez, Ruben, Corzo, Cesar A., Khan, Tanya M., Novick, Scott J., Park, HaJeung, Kojetin, Douglas J., Phinney, Donald G., Bruning, John B., Kamenecka, Theodore M., Griffin, Patrick R.

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Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states von Yan, Yan, Zhou, X. Edward, Novick, Scott J., Shaw, Simon J., Li, Yingwu, Brunzelle, Joseph S., Hitoshi, Yasumichi, Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten

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Stereoselective Reduction of α‑Fluoro-β-ketoesters: Ketoreductases and Dynamic Reductive Kinetic Resolution von Green, Thomas K., Vanagel, Matthew, Damarancha, Anil, Showalter, Brandon, Novick, Scott J., Chagger Maniar, Harvinder

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Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179 von Patil, Dipak N, Pantalone, Serena, Cao, Yan, Laboute, Thibaut, Novick, Scott J, Singh, Shikha, Savino, Simone, Faravelli, Silvia, Magnani, Francesca, Griffin, Patrick R, Singh, Appu K, Forneris, Federico, Martemyanov, Kirill A

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Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing von Gu, Xin, Yan, Yan, Novick, Scott J., Kovach, Amanda, Goswami, Devrishi, Ke, Jiyuan, Tan, M. H. Eileen, Wang, Lili, Li, Xiaodan, de Waal, Parker W., Webb, Martin R., Griffin, Patrick R., Xu, H. Eric, Melcher, Karsten

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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors von Kim, Hyeonwoo, Wrann, Christiane D., Jedrychowski, Mark, Vidoni, Sara, Kitase, Yukiko, Nagano, Kenichi, Zhou, Chenhe, Chou, Joshua, Parkman, Virginia-Jeni A., Novick, Scott J., Strutzenberg, Timothy S., Pascal, Bruce D., Le, Phuong T., Brooks, Daniel J., Roche, Alexander M., Gerber, Kaitlyn K., Mattheis, Laura, Chen, Wenjing, Tu, Hua, Bouxsein, Mary L., Griffin, Patrick R., Baron, Roland, Rosen, Clifford J., Bonewald, Lynda F., Spiegelman, Bruce M.

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Structure–Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production von Lin, Hua, Sharabi, Kfir, Lin, Li, Ruiz, Claudia, Zhu, Di, Cameron, Michael D, Novick, Scott J, Griffin, Patrick R, Puigserver, Pere, Kamenecka, Theodore M

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