Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2... von Payne, Joseph E, Bonnefous, Céline, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dime... von Bonnefous, Céline, Payne, Joseph E, Roppe, Jeffrey, Zhuang, Hui, Chen, Xiaohong, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Severance, Daniel, Walsh, John P, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5 von Herbert, Mark R., Siegel, Dana L., Staszewski, Lena, Cayanan, Charmagne, Banerjee, Urmi, Dhamija, Sangeeta, Anderson, Jennifer, Fan, Amy, Wang, Li, Rix, Peter, Shiau, Andrew K., Rao, Tadimeti S., Noble, Stewart A., Heyman, Richard A., Bischoff, Eric, Guha, Mausumee, Kabakibi, Ayman, Pinkerton, Anthony B.

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Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors von Pinkerton, Anthony B., Lee, Tom T., Hoffman, Timothy Z., Wang, Yan, Kahraman, Mehmet, Cook, Travis G., Severance, Daniel, Gahman, Timothy C., Noble, Stewart A., Shiau, Andrew K., Davis, Robert L.

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Water-soluble PDE4 inhibitors for the treatment of dry eye von Govek, Steven P., Oshiro, Guy, Anzola, John V., Beauregard, Clay, Chen, Jasmine, Coyle, Avery R., Gamache, Daniel A., Hellberg, Mark R., Hsien, Jennifer N., Lerch, Julia M., Liao, John C., Malecha, James W., Staszewski, Lena M., Thomas, David J., Yanni, John M., Noble, Stewart A., Shiau, Andrew K.

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KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo von Hassig, Christian A, Symons, Kent T, Guo, Xin, Nguyen, Phan-Manh, Annable, Tami, Wash, Paul L, Payne, Joseph E, Jenkins, David A, Bonnefous, Céline, Trotter, Carol, Wang, Yan, Anzola, John V, Milkova, Elena L, Hoffman, Timothy Z, Dozier, Sara J, Wiley, Brandon M, Saven, Alan, Malecha, James W, Davis, Robert L, Muhammad, Jerry, Shiau, Andrew K, Noble, Stewart A, Rao, Tadimeti S, Smith, Nicholas D, Hager, Jeffrey H

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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents von Henke, Brad R, Blanchard, Steven G, Brackeen, Marcus F, Brown, Kathleen K, Cobb, Jeff E, Collins, Jon L, Harrington, W. Wallace, Hashim, Mir A, Hull-Ryde, Emily A, Kaldor, Istvan, Kliewer, Steven A, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen M, Lenhard, James M, Orband-Miller, Lisa A, Miller, John F, Mook, Robert A, Noble, Stewart A, Oliver, William, Parks, Derek J, Plunket, Kelli D, Szewczyk, Jerzy R, Willson, Timothy M

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Discovery of Lu AA33810: A highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder von Packiarajan, Mathivanan, Marzabadi, Mohammad R., Desai, Mahesh, Lu, Yalei, Noble, Stewart A., Wong, Wai C., Jubian, Vrej, Chandrasena, Gamini, Wolinsky, Toni D., Zhong, Hualing, Walker, Mary W., Wiborg, Ove, Andersen, Kim

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Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma von Davis, Robert L., Kahraman, Mehmet, Prins, Thomas J., Beaver, Yan, Cook, Travis G., Cramp, Jessica, Cayanan, Charmagne S., Gardiner, Elisabeth M.M., McLaughlin, Marsha A., Clark, Abbot F., Hellberg, Mark R., Shiau, Andrew K., Noble, Stewart A., Borchardt, Allen J.

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Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors von Gahman, Timothy C., Herbert, Mark R., Lang, Henk, Thayer, Angie, Symons, Kent T., Nguyen, Phan Manh, Massari, Mark E., Dozier, Sara, Zhang, Yan, Sablad, Marciano, Rao, Tadimeti S., Noble, Stewart A., Shiau, Andrew K., Hassig, Christian A.

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KLYP956 Is a Non-Imidazole-Based Orally Active Inhibitor of Nitric-Oxide Synthase Dimerization von Symons, Kent T, Massari, Mark E, Nguyen, Phan M, Lee, Tom T, Roppe, Jeffrey, Bonnefous, Céline, Payne, Joseph E, Smith, Nicholas D, Noble, Stewart A, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Rao, Tadimeti S, Shiau, Andrew K, Hassig, Christian A

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Identification of KD5170 : A novel mercaptoketone-based histone deacetylase inhibitor von PAYNE, Joseph E, BONNEFOUS, Céline, SHIAU, Andrew K, MALECHA, James W, NOBLE, Stewart A, HAGER, Jeffrey H, SMITH, Nicholas D, HASSIG, Christian A, SYMONS, Kent T, XIN GUO, NGUYEN, Phan-Manh, ANNABLE, Tami, WASH, Paul L, HOFFMAN, Timothy Z, RAO, Tadimeti S

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Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases von Symons, Kent T, Nguyen, Phan M, Massari, Mark E, Anzola, John V, Staszewski, Lena M, Wang, Li, Yazdani, Nahid, Dorow, Steven, Muhammad, Jerry, Sablad, Marciano, Rozenkrants, Natasha, Bonefous, Celine, Payne, Joseph E, Rix, Peter J, Shiau, Andrew K, Noble, Stewart A, Smith, Nicholas D, Hassig, Christian A, Zhang, Yan, Rao, Tadimeti S

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Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors von Durón, Sergio G., Lindstrom, Andrew, Bonnefous, Céline, Zhang, Hui, Chen, Xiaohong, Symons, Kent T., Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K., Noble, Stewart A., Rix, Peter, Rao, Tadimeti S., Hassig, Christian A., Smith, Nicholas D.

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Synthesis and Structure−Activity Relationship of Fluoro Analogues of 8-{2-[4-(4-Methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as Selective α1d-Adrenergic Recep... von Konkel, Michael J, Wetzel, John M, Cahir, Marie, Craig, Douglas A, Noble, Stewart A, Gluchowski, Charles

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α-Mercaptoketone based histone deacetylase inhibitors von Wash, Paul L., Hoffman, Timothy Z., Wiley, Brandon M., Bonnefous, Céline, Smith, Nicholas D., Sertic, Michael S., Lawrence, Charles M., Symons, Kent T., Nguyen, Phan-Manh, Lustig, Kevin D., Guo, Xin, Annable, Tami, Noble, Stewart A., Hager, Jeffrey H., Hassig, Christian A., Malecha, James W.

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Antisense and Antigene Properties of Peptide Nucleic Acids von Hanvey, Jeffery C., Peffer, Nancy J., Bisi, John E., Thomson, Stephen A., Cadilla, Rodolfo, Josey, John A., Ricca, Daniel J., Hassman, C. Fred, Bonham, Michele A., Au, Karin G., Carter, Stephen G., Bruckenstein, David A., Boyd, Ann L., Noble, Stewart A., Babiss, Lee E.

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GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2 von Jones, K A, Borowsky, B, Tamm, J A, Craig, D A, Durkin, M M, Dai, M, Yao, W J, Johnson, M, Gunwaldsen, C, Huang, L Y, Tang, C, Shen, Q, Salon, J A, Morse, K, Laz, T, Smith, K E, Nagarathnam, D, Noble, S A, Branchek, T A, Gerald, C

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An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers von Bonham, Michele A., Brown, Stephen, Boyd, Ann L., Brown, Pamela H., Bruckenstein, David A., Hanvey, Jeffery C., Thomson, Stephen A., Pipe, Adrian, Hassman, Fred, Bisi, John E., Froehler, Brian C., Matteucci, Mark D., Wagner, Richard W., Noble, Stewart A., Babiss, Lee E.

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Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines von Livermore, David G. H, Bethell, Richard C, Cammack, Nicholas, Hancock, Ashley P, Hann, Michael M, Green, Darren V. S, Lamont, R. Brian, Noble, Stewart A, Orr, David C

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