Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders von Njomen, Evert, Tepe, Jetze J

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Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma von Njomen, Evert, Vanecek, Allison, Lansdell, Theresa A, Yang, Ya-Ting, Schall, Peter Z, Harris, Christi M, Bernard, Matthew P, Isaac, Daniel, Alkharabsheh, Omar, Al-Janadi, Anas, Giletto, Matthew B, Ellsworth, Edmund, Taylor, Catherine, Tang, Terence, Lau, Sarah, Bailie, Marc, Bernard, Jamie J, Yuzbasiyan-Gurkan, Vilma, Tepe, Jetze J

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Regulation of Autophagic Flux by the 20S Proteasome von Njomen, Evert, Tepe, Jetze J.

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Development and Validation of a High-Throughput Cell-Based AlphaLISA Assay to Identify Small Molecule 20S Proteasome Modulators von Lisabeth, Erika, Staerz, Sophia, Njomen, Evert, Dexheimer, Thomas, Neubig, Richard, Tepe, Jetze

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Small Molecule Modulation of Proteasome Assembly von Njomen, Evert, Osmulski, Pawel A, Jones, Corey L, Gaczynska, Maria, Tepe, Jetze J

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Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain von Feldman, Hannah C., Merlini, Elisa, Guijas, Carlos, DeMeester, Kristen E., Njomen, Evert, Kozina, Ellen M., Yokoyama, Minoru, Vinogradova, Ekaterina, Reardon, Holly T., Melillo, Bruno, Schreiber, Stuart L., Loreto, Andrea, Blankman, Jacqueline L., Cravatt, Benjamin F.

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Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins von Jones, Corey L, Njomen, Evert, Sjögren, Benita, Dexheimer, Thomas S, Tepe, Jetze J

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Assigning functionality to cysteines by base editing of cancer dependency genes von Li, Haoxin, Ma, Tiantai, Remsberg, Jarrett R., Won, Sang Joon, DeMeester, Kristen E., Njomen, Evert, Ogasawara, Daisuke, Zhao, Kevin T., Huang, Tony P., Lu, Bingwen, Simon, Gabriel M., Melillo, Bruno, Schreiber, Stuart L., Lykke-Andersen, Jens, Liu, David R., Cravatt, Benjamin F.

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Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2 von Tao, Yongfeng, Felber, Jan G., Zou, Zhongyu, Njomen, Evert, Remsberg, Jarrett R., Ogasawara, Daisuke, Ye, Chang, Melillo, Bruno, Schreiber, Stuart L., He, Chuan, Remillard, David, Cravatt, Benjamin F.

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Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders von Liu, Zhonglin, Remsberg, Jarrett R., Li, Haoxin, Njomen, Evert, DeMeester, Kristen E., Tao, Yongfeng, Xia, Guoqin, Hayward, Rachel E., Yoo, Minjin, Nguyen, Tracey, Simon, Gabriel M., Schreiber, Stuart L., Melillo, Bruno, Cravatt, Benjamin F.

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Proteomic discovery of chemical probes that perturb protein complexes in human cells von Lazear, Michael R., Remsberg, Jarrett R., Jaeger, Martin G., Rothamel, Katherine, Her, Hsuan-lin, DeMeester, Kristen E., Njomen, Evert, Hogg, Simon J., Rahman, Jahan, Whitby, Landon R., Won, Sang Joon, Schafroth, Michael A., Ogasawara, Daisuke, Yokoyama, Minoru, Lindsey, Garrett L., Li, Haoxin, Germain, Jason, Barbas, Sabrina, Vaughan, Joan, Hanigan, Thomas W., Vartabedian, Vincent F., Reinhardt, Christopher J., Dix, Melissa M., Koo, Seong Joo, Heo, Inha, Teijaro, John R., Simon, Gabriel M., Ghosh, Brahma, Abdel-Wahab, Omar, Ahn, Kay, Saghatelian, Alan, Melillo, Bruno, Schreiber, Stuart L., Yeo, Gene W., Cravatt, Benjamin F.

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Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells von Njomen, Evert, Hayward, Rachel E., DeMeester, Kristen E., Ogasawara, Daisuke, Dix, Melissa M., Nguyen, Tracey, Ashby, Paige, Simon, Gabriel M., Schreiber, Stuart L., Melillo, Bruno, Cravatt, Benjamin F.

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Redirecting the pioneering function of FOXA1 with covalent small molecules von Won, Sang Joon, Zhang, Yuxiang, Reinhardt, Christopher J., Hargis, Lauren M., MacRae, Nicole S., DeMeester, Kristen E., Njomen, Evert, Remsberg, Jarrett R., Melillo, Bruno, Cravatt, Benjamin F., Erb, Michael A.

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Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes von Ogasawara, Daisuke, Konrad, David B., Tan, Zher Yin, Carey, Kimberly L., Luo, Jessica, Won, Sang Joon, Li, Haoxin, Carter, Trever R., DeMeester, Kristen E., Njomen, Evert, Schreiber, Stuart L., Xavier, Ramnik J., Melillo, Bruno, Cravatt, Benjamin F.

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Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly von Stanton, Caroline, Sun, Jie, Nutsch, Kayla, Rosarda, Jessica D., Nguyen, Thu, Li-Ma, Chloris, Njomen, Evert, Melillo, Bruno, Kutseikin, Sergei, Saez, Enrique, Cravatt, Benjamin F., Teijaro, John R., Wiseman, R. Luke, Bollong, Michael J.

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Development of a Cell-Based AlphaLISA Assay for High-Throughput Screening for Small Molecule Proteasome Modulators von Staerz, Sophia D., Lisabeth, Erika M., Njomen, Evert, Dexheimer, Thomas S., Neubig, Richard R., Tepe, Jetze J.

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Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2 von Tao, Yongfeng, Felber, Jan G., Zou, Zhongyu, Njomen, Evert, Remsberg, Jarrett R., Ogasawara, Daisuke, Ye, Chang, Melillo, Bruno, Schreiber, Stuart L., He, Chuan, Remillard, David, Cravatt, Benjamin F.

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Substituted dibenzo[b, f]azepines as proteasome activators von Jones, Corey Lee, Lansdell, Theresa A, Njomen, Evert, Tepe, Jetze J

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SMALL MOLECULE ENHANCEMENT OF 20S PROTEASOME ACTIVITY TARGETS INTRINSICALLY DISORDERED PROTEINS von Jones, Corey Lee, Lansdell, Theresa A, Njomen, Evert, Tepe, Jetze J

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Substituted phenothiazines as proteasome activators von Jones, Corey Lee, Lansdell, Theresa A, Njomen, Evert, Tepe, Jetze J

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