Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection von Summa, Vincenzo, Petrocchi, Alessia, Bonelli, Fabio, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Fiore, Fabrizio, Gardelli, Cristina, Gonzalez Paz, Odalys, Hazuda, Daria J, Jones, Philip, Kinzel, Olaf, Laufer, Ralph, Monteagudo, Edith, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Scarpelli, Rita, Stillmock, Kara, Witmer, Marc V, Rowley, Michael

Volltext

Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production von Guidi, Alessandra, Lalli, Cristiana, Gimmelli, Roberto, Nizi, Emanuela, Andreini, Matteo, Gennari, Nadia, Saccoccia, Fulvio, Harper, Steven, Bresciani, Alberto, Ruberti, Giovina

Volltext

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production von Guidi, Alessandra, Saccoccia, Fulvio, Gennari, Nadia, Gimmelli, Roberto, Nizi, Emanuela, Lalli, Cristiana, Paonessa, Giacomo, Papoff, Giuliana, Bresciani, Alberto, Ruberti, Giovina

Volltext

Synthesis of a hexahydropyrimido[1,2- a]azepine-2-carboxamide derivative useful as an HIV integrase inhibitor von Ferrara, Marco, Crescenzi, Benedetta, Donghi, Monica, Muraglia, Ester, Nizi, Emanuela, Pesci, Silvia, Summa, Vincenzo, Gardelli, Cristina

Volltext

Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins von Nizi, Emanuela, Sferrazza, Alessio, Fabbrini, Danilo, Nardi, Valentina, Andreini, Matteo, Graziani, Rita, Gennari, Nadia, Bresciani, Alberto, Paonessa, Giacomo, Harper, Steven

Volltext

Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors von Ponzi, Simona, Bresciani, Alberto, Kaiser, Marcel, Nardi, Valentina, Nizi, Emanuela, Ontoria, Jesus M., Pace, Paola, Paonessa, Giacomo, Summa, Vincenzo, Harper, Steven

Volltext

Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors von Ettari, Roberta, Nizi, Emanuela, Di Francesco, Maria Emilia, Dude, Marie-Adrienne, Pradel, Gabriele, Vičík, Radim, Schirmeister, Tanja, Micale, Nicola, Grasso, Silvana, Zappalà, Maria

Volltext

Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides von Bresciani, Alberto, Ontoria, Jesus M, Biancofiore, Ilaria, Cellucci, Antonella, Ciammaichella, Alina, Di Marco, Annalise, Ferrigno, Federica, Francone, Alessandra, Malancona, Savina, Monteagudo, Edith, Nizi, Emanuela, Pace, Paola, Ponzi, Simona, Rossetti, Ilaria, Veneziano, Maria, Summa, Vincenzo, Harper, Steven

Volltext

Novel Peptidomimetics Containing a Vinyl Ester Moiety as Highly Potent and Selective Falcipain-2 Inhibitors von Ettari, Roberta, Micale, Nicola, Schirmeister, Tanja, Gelhaus, Christoph, Leippe, Matthias, Nizi, Emanuela, Di Francesco, Maria Emilia, Grasso, Silvana, Zappalà, Maria

Volltext

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor von Harper, Steven, McCauley, John A, Rudd, Michael T, Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W, Romano, Joseph J, Bush, Kimberly J, Gilbert, Kevin F, McIntyre, Charles J, Nguyen, Kevin T, Nizi, Emanuela, Carroll, Steven S, Ludmerer, Steven W, Burlein, Christine, DiMuzio, Jillian M, Graham, Donald J, McHale, Carolyn M, Stahlhut, Mark W, Olsen, David B, Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M, Rowley, Michael, Coleman, Paul J, Vacca, Joseph P, Summa, Vincenzo, Liverton, Nigel J

Volltext

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs von Ontoria, Jesus M, Paonessa, Giacomo, Ponzi, Simona, Ferrigno, Federica, Nizi, Emanuela, Biancofiore, Ilaria, Malancona, Savina, Graziani, Rita, Roberts, David, Willis, Paul, Bresciani, Alberto, Gennari, Nadia, Cecchetti, Ottavia, Monteagudo, Edith, Orsale, Maria V, Veneziano, Maria, Di Marco, Annalise, Cellucci, Antonella, Laufer, Ralph, Altamura, Sergio, Summa, Vincenzo, Harper, Steven

Volltext

Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors von Pace, Paola, Di Francesco, M. Emilia, Gardelli, Cristina, Harper, Steven, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Petrocchi, Alessia, Poma, Marco, Rowley, Michael, Scarpelli, Rita, Laufer, Ralph, Gonzalez Paz, Odalys, Monteagudo, Edith, Bonelli, Fabio, Hazuda, Daria, Stillmock, Kara A, Summa, Vincenzo

Volltext

Discovery and Synthesis of HIV Integrase Inhibitors:  Development of Potent and Orally Bioavailable N-Methyl Pyrimidones von Gardelli, Cristina, Nizi, Emanuela, Muraglia, Ester, Crescenzi, Benedetta, Ferrara, Marco, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Poma, Marco, Rico Ferreira, Maria del Rosario, Scarpelli, Rita, Homnick, Carl F, Ikemoto, Norihiro, Alfieri, Anna, Verdirame, Maria, Bonelli, Fabio, Gonzalez Paz, Odalys, Taliani, Marina, Monteagudo, Edith, Pesci, Silvia, Laufer, Ralph, Felock, Peter, Stillmock, Kara A, Hazuda, Daria, Rowley, Michael, Summa, Vincenzo

Volltext

Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors von Muraglia, Ester, Kinzel, Olaf, Gardelli, Cristina, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Nizi, Emanuela, Orvieto, Federica, Pescatore, Giovanna, Laufer, Ralph, Gonzalez-Paz, Odalys, Di Marco, Annalise, Fiore, Fabrizio, Monteagudo, Edith, Fonsi, Massimiliano, Felock, Peter J, Rowley, Michael, Summa, Vincenzo

Volltext

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain-2 Inhibitors von Ettari, Roberta, Nizi, Emanuela, Di Francesco, Maria Emilia, Micale, Nicola, Grasso, Silvana, Zappalà, Maria, Vičík, Radim, Schirmeister, Tanja

Volltext

Novel Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease Featuring a 2-Amino-1,3-thiazole as a P4 Carbamate Replacement von Di Francesco, M. Emilia, Dessole, Gabriella, Nizi, Emanuela, Pace, Paola, Koch, Uwe, Fiore, Fabrizio, Pesci, Silvia, Di Muzio, Jillian, Monteagudo, Edith, Rowley, Michael, Summa, Vincenzo

Volltext

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase von Pace, Paola, Nizi, Emanuela, Pacini, Barbara, Pesci, Silvia, Matassa, Victor, De Francesco, Raffaele, Altamura, Sergio, Summa, Vincenzo

Volltext

Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: Improving cell based activity by the quaternarization of a chiral center von Nizi, Emanuela, Orsale, Maria Vittoria, Crescenzi, Benedetta, Pescatore, Giovanna, Muraglia, Ester, Alfieri, Anna, Gardelli, Cristina, Spieser, Stéphane A.H., Summa, Vincenzo

Volltext

Capped dipeptide α-Ketoacid inhibitors of the HCV NS3 protease von Nizi, Emanuela, Koch, Uwe, Ponzi, Simona, Matassa, Victor G, Gardelli, Cristina

Volltext

Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease von NIZI, Emanuela, KOCH, Uwe, ONTORIA, Jesus M, MARCHETTI, Antonella, NARJES, Frank, MALANCONA, Savina, MATASSA, Victor G, GARDELLI, Cristina

Volltext