A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of sarilumab in patients with giant cell arteritis von Schmidt, Wolfgang A, Dasgupta, Bhaskar, Sloane, Jennifer, Giannelou, Angeliki, Xu, Yuqing, Unizony, Sebastian H, Mackie, Sarah L, Gonzalez-Gay, Miguel A, Spiera, Robert, Warrington, Kenneth J, Villiger, Peter M, Nivens, Michael C, Akinlade, Bolanle, Lin, Yong, Buttgereit, Frank, Stone, John H

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Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment von Hall, Ian P, Fowler, Andrew V, Gupta, Abhya, Tetzlaff, Kay, Nivens, Michael C, Sarno, Maria, Finnigan, Helen A, Bateman, Eric D, Rand Sutherland, E

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Pharmacokinetics and pharmacodynamics of itepekimab in adults with moderate‐to‐severe atopic dermatitis: Results from two terminated phase II trials von Kosloski, Matthew P., Guttman‐Yassky, Emma, Cork, Michael J., Worm, Margitta, Nahm, Dong‐Ho, Zhu, Xiaoping, Ruddy, Marcella K., Harel, Sivan, Kamal, Mohamed A., Goulaouic, Hélène, Xu, Christine R., Avetisova, Elena, Davis, John D., Nivens, Michael C., Shabbir, Arsalan, Radin, Allen

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Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma von Wechsler, Michael E, Ruddy, Marcella K, Pavord, Ian D, Israel, Elliot, Rabe, Klaus F, Ford, Linda B, Maspero, Jorge F, Abdulai, Raolat M, Hu, Chih-Chi, Martincova, Renata, Jessel, Andreas, Nivens, Michael C, Amin, Nikhil, Weinreich, David M, Yancopoulos, George D, Goulaouic, Helene

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Safety and Efficacy of an Inhaled Epidermal Growth Factor Receptor Inhibitor (BIBW 2948 BS) in Chronic Obstructive Pulmonary Disease von Woodruff, Prescott G, Wolff, Michael, Hohlfeld, Jens M, Krug, Norbert, Dransfield, Mark T, Sutherland, E. Rand, Criner, Gerard J, Kim, Victor, Prasse, Antje, Nivens, Michael C, Tetzlaff, Kay, Heilker, Ralf, Fahy, John V

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Population Pharmacodynamic Model of Neutrophil Margination and Tolerance to Describe Effect of Sarilumab on Absolute Neutrophil Count in Patients with Rheumatoid Arthritis von Kovalenko, Pavel, Paccaly, Anne, Boyapati, Anita, Xu, Christine, St John, Gregory, Nivens, Michael C., Davis, John D., Rippley, Ronda, DiCioccio, A. Thomas

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AERIFY-1/2: two phase 3, randomised, controlled trials of itepekimab in former smokers with moderate-to-severe COPD von Rabe, Klaus F, Martinez, Fernando J, Bhatt, Surya P, Kawayama, Tomotaka, Cosio, Borja G, Mroz, Robert M, Boomsma, Maarten M, Goulaouic, Helene, Nivens, Michael C, Djandji, Michel, Soler, Xavier, Liu, Ying, Kosloski, Matthew P, Xu, Christine R, Amin, Nikhil, Staudinger, Heribert, Lederer, David J, Abdulai, Raolat M

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Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper von Spiera, Robert F., Unizony, Sebastian, Warrington, Kenneth J., Sloane, Jennifer, Giannelou, Angeliki, Nivens, Michael C., Akinlade, Bolanle, Wong, Wanling, Bhore, Rafia, Lin, Yong, Buttgereit, Frank, Devauchelle-Pensec, Valerie, Rubbert-Roth, Andrea, Yancopoulos, George D., Marrache, Frederic, Patel, Naimish, Dasgupta, Bhaskar

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Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial von Rabe, Klaus F, Celli, Bartolome R, Wechsler, Michael E, Abdulai, Raolat M, Luo, Xiaodong, Boomsma, Maarten M, Staudinger, Heribert, Horowitz, Julie E, Baras, Aris, Ferreira, Manuel A, Ruddy, Marcella K, Nivens, Michael C, Amin, Nikhil, Weinreich, David M, Yancopoulos, George D, Goulaouic, Helene

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Baseline Severe Acute Respiratory Syndrome Viral Load Is Associated With Coronavirus Disease 2019 Severity and Clinical Outcomes: Post Hoc Analyses of a Phase 2/3 Trial von Boyapati, Anita, Wipperman, Matthew F, Ehmann, Peter J, Hamon, Sara, Lederer, David J, Waldron, Alpana, Flanagan, John J, Karayusuf, Elif, Bhore, Rafia, Nivens, Michael C, Hamilton, Jennifer D, Sumner, Giane, Sivapalasingam, Sumathi

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Differential Binding of Sarilumab and Tocilizumab to IL‐6Rα and Effects of Receptor Occupancy on Clinical Parameters von Xu, Christine, Rafique, Ashique, Potocky, Terra, Paccaly, Anne, Nolain, Patrick, Lu, Qiang, Iglesias‐Rodriguez, Melitza, St John, Gregory, Nivens, Michael C., Kanamaluru, Vanaja, Fairhurst, Jeanette, Ishii, Tomonori, Maldonado, Rafael, Choy, Ernest, Emery, Paul

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Efficacy and Safety of Sarilumab in Hospitalized Patients With Coronavirus Disease 2019: A Randomized Clinical Trial von Sivapalasingam, Sumathi, Lederer, David J, Bhore, Rafia, Hajizadeh, Negin, Criner, Gerard, Hosain, Romana, Mahmood, Adnan, Giannelou, Angeliki, Somersan-Karakaya, Selin, O’Brien, Meagan P, Boyapati, Anita, Parrino, Janie, Musser, Bret J, Labriola-Tompkins, Emily, Ramesh, Divya, Purcell, Lisa A, Gulabani, Daya, Kampman, Wendy, Waldron, Alpana, Ng Gong, Michelle, Saggar, Suraj, Sperber, Steven J, Menon, Vidya, Stein, David K, Sobieszczyk, Magdalena E, Park, William, Aberg, Judith A, Brown, Samuel M, Kosmicki, Jack A, Horowitz, Julie E, Ferreira, Manuel A, Baras, Aris, Kowal, Bari, Thomas DiCioccio, A, Akinlade, Bolanle, Nivens, Michael C, Braunstein, Ned, Herman, Gary A, Yancopoulos, George D, Weinreich, David M

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IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels von Faiz, Alen, Mahbub, Rashad M, Boedijono, Fia Sabrina, Tomassen, Milan I, Kooistra, Wierd, Timens, Wim, Nawijn, Martijn, Hansbro, Philip M, Johansen, Matt D, Pouwels, Simon D, Heijink, Irene H, Massip, Florian, de Biase, Maria Stella, Schwarz, Roland F, Adcock, Ian M, Chung, Kian F, van der Does, Anne, Hiemstra, Pieter S, Goulaouic, Helene, Xing, Heming, Abdulai, Raolat, de Rinaldis, Emanuele, Cunoosamy, Danen, Harel, Sivan, Lederer, David, Nivens, Michael C, Wark, Peter A, Kerstjens, Huib A M, Hylkema, Machteld N, Brandsma, Corry-Anke, van den Berge, Maarten

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Pharmacokinetics of Subcutaneous Itepekimab Injection With an Autoinjector Device and Prefilled Syringe in Healthy Participants von Xu, Christine, Xin, Kong, Kosloski, Matthew P., Butler, Allison, Goulaouic, Helene, Nivens, Michael C., Kanamaluru, Vanaja

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Dupilumab improves pruritus and skin lesions in patients with prurigo nodularis: Pooled results from 2 phase 3 trials (LIBERTY-PN PRIME and PRIME2) von Yosipovitch, Gil, Kim, Brian S., Kwatra, Shawn G., Mollanazar, Nicholas K., Ständer, Sonja, Satoh, Takahiro, Mendes-Bastos, Pedro, Tsai, Tsen-Fang, Laws, Elizabeth, Nivens, Michael C., Maloney, Jennifer, Shi, Genming, Bansal, Ashish, Dubost-Brama, Ariane

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The 24-h FEV1 time profile of olodaterol once daily via Respimat® and formoterol twice daily via Aerolizer® in patients with GOLD 2–4 COPD: results from two 6-week crossover studie... von Feldman, Gregory J, Bernstein, Jonathan A, Hamilton, Alan, Nivens, Michael C, Korducki, Lawrence, LaForce, Craig

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Responsiveness of the cough and sputum assessment questionnaire in exacerbations of COPD and chronic bronchitis von Monz, Brigitta U, Sachs, Paul, McDonald, Jeffrey, Crawford, Bruce, Nivens, Michael C, Tetzlaff, Kay

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Is the EQ-5D responsive to recovery from a moderate COPD exacerbation? von Goossens, Lucas M.A, Nivens, Michael C, Sachs, Paul, Monz, Brigitta U, Rutten-van Mölken, Maureen P.M.H

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In vivo inhibition of epidermal growth factor receptor autophosphorylation prevents receptor internalization von Wolff, Michael, Tetzlaff, Kay, Nivens, Michael C., Schneider, Franz-Josef, Jung, Birgit, Hohlfeld, Jens, Heilker, Ralf

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Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 AMeta-analysis von Shankar-Hari, M, Vale, CL, Godolphin, PJ, Fisher, D, Higgins, JPT, Spiga, F, Savovic, J, Tierney, J, Baron, G, Benbenishty, JS

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