Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy von Myers, Robert W., Guan, Hong-Ping, Ehrhart, Juliann, Petrov, Aleksandr, Prahalada, Srinivasa, Tozzo, Effie, Yang, Xiaodong, Kurtz, Marc M., Trujillo, Maria, Trotter, Dinko Gonzalez, Feng, Danqing, Xu, Shiyao, Eiermann, George, Holahan, Marie A., Rubins, Daniel, Conarello, Stacey, Niu, Xiaoda, Souza, Sandra C., Miller, Corin, Liu, Jinqi, Lu, Ku, Feng, Wen, Li, Ying, Painter, Ronald E., Milligan, James A., He, Huaibing, Liu, Franklin, Ogawa, Aimie, Wisniewski, Douglas, Rohm, Rory J., Wang, Liyang, Bunzel, Michelle, Qian, Ying, Zhu, Wei, Wang, Hongwu, Bennet, Bindu, Scheuch, Lisa LaFranco, Fernandez, Guillermo E., Li, Cai, Klimas, Michael, Zhou, Gaochao, van Heek, Margaret, Biftu, Tesfaye, Weber, Ann, Kelley, David E., Thornberry, Nancy, Erion, Mark D., Kemp, Daniel M., Sebhat, Iyassu K.

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Discovery and SAR of hydantoin TACE inhibitors von Yu, Wensheng, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Girijavallabhan, Vinay M., Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Li, Dansu, Lundell, Daniel, Niu, Xiaoda, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle B., Shih, Neng-Yang, Arshad Siddiqui, M., Sun, Jing, Tong, Ling, Umland, Shelby, Wong, Michael K.C., Yang, De-yi, Zhou, Guowei

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Discovery of Novel Hydroxamates as Highly Potent Tumor Necrosis Factor-α Converting Enzyme Inhibitors: Part IDiscovery of Two Binding Modes von Zhu, Zhaoning, Mazzola, Robert, Sinning, Lisa, McKittrick, Brian, Niu, Xiaoda, Lundell, Daniel, Sun, Jing, Orth, Peter, Guo, Zhuyan, Madison, Vincent, Ingram, Richard, Beyer, Brian M

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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors von Dai, Chaoyang, Li, Dansu, Popovici-Muller, Janeta, Zhao, Lianyun, Girijavallabhan, Vinay M., Rosner, Kristin E., Lavey, Brian J., Rizvi, Razia, Shankar, Bandarpalle B., Wong, Michael K.C., Guo, Zhuyan, Orth, Peter, Strickland, Corey O., Sun, Jing, Niu, Xiaoda, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Piwinski, John J., Shih, Neng-Yang, Siddiqui, M. Arshad

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Biaryl substituted hydantoin compounds as TACE inhibitors von Yu, Wensheng, Tong, Ling, Kim, Seong Heon, Wong, Michael K.C., Chen, Lei, Yang, De-Yi, Shankar, Bandarpalle B., Lavey, Brian J., Zhou, Guowei, Kosinski, Aneta, Rizvi, Razia, Li, Dansu, Feltz, Robert J., Piwinski, John J., Rosner, Kristin E., Shih, Neng-Yang, Siddiqui, M. Arshad, Guo, Zhuyan, Orth, Peter, Shah, Himanshu, Sun, Jing, Umland, Shelby, Lundell, Daniel J., Niu, Xiaoda, Kozlowski, Joseph A.

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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors von Rosner, Kristin E., Guo, Zhuyan, Orth, Peter, Shipps, Gerald W., Belanger, David B., Chan, Tin Yau, Curran, Patrick J., Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M., Hong, Liwu, Lavey, Brian J., Lee, Joe F., Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C., Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng -Yang, Arshad Siddiqui, M., Strickland, Corey O.

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Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors von Guo, Zhuyan, Orth, Peter, Wong, Shing-Chun, Lavey, Brian J., Shih, Neng-Yang, Niu, Xiaoda, Lundell, Daniel J., Madison, Vincent, Kozlowski, Joseph A.

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Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases von Girijavallabhan, Vinay M., Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Firmansjah, Luke, Li, Dansu, Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Kosinski, Aneta, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Banderpalle B., Shih, Neng-Yang, Siddiqui, M. Arshad, Tong, Ling, Wong, Michael K.C., Yang, De-yi, Yang, Liping, Yu, Wensheng, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Bian, Hong, Lundell, Daniel, Niu, Xiaoda, Shah, Himanshu, Sun, Jing, Umland, Shelby

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Structure and activity relationships of tartrate-based TACE inhibitors von Li, Dansu, Popovici-Muller, Janeta, Belanger, David B., Caldwell, John, Dai, Chaoyang, David, Maria, Girijavallabhan, Vinay M., Lavey, Brian J., Lee, Joe F., Liu, Zhidan, Mazzola, Rob, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle, Spitler, Jim, Ting, Pauline C., Vaccaro, Henry, Yu, Wensheng, Zhou, Guowei, Zhu, Zhaoning, Niu, Xiaoda, Sun, Jing, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng-Yang, Shipps, Gerald W., Siddiqui, M. Arshad, Strickland, Corey O.

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Highly selective hydrogenation of CO2 to C5+ hydrocarbons over Fe catalysts copromoted by K with Pd von Xiong, Liangmin, Liu, Shuang, Men, Yong, Li, Lin, Niu, Xiaoda, Guo, Kailiang, Xu, Junzhe, An, Wei, Wang, Jinguo, Cong, Yu

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Synergistic Catalysis of PdFe Bimetallic Nanoparticles Supported on SiO2 for Hydrogenative Cleavage of C–N Bonds von Chen, Shuyuan, Liu, Shuang, Men, Yong, Li, Lin, Li, Xiaoyu, Pan, Xiaoli, Sun, Chenghui, Xiong, Liangmin, Niu, Xiaoda, An, Wei, Wang, Jinguo, Wang, Yuanqiang

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TiO2 supported Pd nanoclusters with surface defects toward highly efficient hydrogenation of quinone to hydroquinone under mild conditions von Niu, Xiaoda, Liu, Shuang, Men, Yong, Li, Lin, Xiong, Liangmin, Guo, Kailiang, Xu, Junzhe, Zhao, Kunfeng, Li, Ya, An, Wei, Wang, Jinguo

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Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors von Tong, Ling, Kim, Seong Heon, Rosner, Kristin, Yu, Wensheng, Shankar, Bandarpalle B., Chen, Lei, Li, Dansu, Dai, Chaoyang, Girijavallabhan, Vinay, Popovici-Muller, Janeta, Yang, Liping, Zhou, Guowei, Kosinski, Aneta, Siddiqui, M. Arshad, Shih, Neng-Yang, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Lundell, Daniel, Niu, Xiaoda, Umland, Shelby, Kozlowski, Joseph A.

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Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors von Hanisak, Jennifer, Seganish, W. Michael, McElroy, William T., Tang, Haiquin, Zhang, Rui, Tsui, Hon-Chung, Fischmann, Theirry, Tulshian, Deen, Tata, James, Sondey, Christopher, Devito, Kristine, Fossetta, James, Garlisi, Charles G., Lundell, Daniel, Niu, Xiaoda

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Synergistic Catalysis of PdFe Bimetallic Nanoparticles Supported on SiO 2 for Hydrogenative Cleavage of C–N Bonds von Chen, Shuyuan, Liu, Shuang, Men, Yong, Li, Lin, Li, Xiaoyu, Pan, Xiaoli, Sun, Chenghui, Xiong, Liangmin, Niu, Xiaoda, An, Wei, Wang, Jinguo, Wang, Yuanqiang

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Development of a prodrug of hydantoin based TACE inhibitor von Tong, Ling, Kim, Seong Heon, Chen, Lei, Kosinski, Aneta, Shankar, Bandarpalle B., Girijavallabhan, Vinay, Yang, De-Yi, Yu, Wensheng, Zhou, Guowei, Shih, Neng-Yang, Chen, Shiying, Hu, Mengwei, Lundell, Daniel, Niu, Xiaoda, Umland, Shelby, Kozlowski, Joseph A.

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Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation von McElroy, William T., Tan, Zheng, Ho, Ginny, Paliwal, Sunil, Li, Guoqing, Seganish, W. Michael, Tulshian, Deen, Tata, James, Fischmann, Thierry O., Sondey, Christopher, Bian, Hong, Bober, Loretta, Jackson, James, Garlisi, Charles G., Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda

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Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4 von McElroy, William T, Michael Seganish, W, Jason Herr, R, Harding, James, Yang, Jinhai, Yet, Larry, Komanduri, Venukrishnan, Prakash, Koraboina Chandra, Lavey, Brian, Tulshian, Deen, Greenlee, William J, Sondey, Christopher, Fischmann, Thierry O, Niu, Xiaoda

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Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4 von Seganish, W. Michael, McElroy, William T., Herr, R. Jason, Brumfield, Stephanie, Greenlee, William J., Harding, James, Komanduri, Venukrishnan, Matasi, Julius, Prakash, Koraboina Chandra, Tulshian, Deen, Yang, Jinhai, Yet, Larry, Devito, Kristine, Fossetta, James, Garlisi, Charles G., Lundell, Daniel, Niu, Xiaoda, Sondey, Christopher

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Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors von Seganish, W. Michael, Fischmann, Thierry O, Sherborne, Brad, Matasi, Julius, Lavey, Brian, McElroy, William T, Tulshian, Deen, Tata, James, Sondey, Christopher, Garlisi, Charles G, Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda

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