Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis von Kitani, Shigeru, Miyamoto, Kiyoko T, Takamatsu, Satoshi, Herawati, Elisa, Iguchi, Hiroyuki, Nishitomi, Kouhei, Uchida, Miho, Nagamitsu, Tohru, Omura, Satoshi, Ikeda, Haruo, Nihira, Takuya

Volltext

Semagacestat Is a Pseudo-Inhibitor of γ-Secretase von Tagami, Shinji, Yanagida, Kanta, Kodama, Takashi S., Takami, Mako, Mizuta, Naoki, Oyama, Hiroshi, Nishitomi, Kouhei, Chiu, Yu-wen, Okamoto, Toru, Ikeuchi, Takeshi, Sakaguchi, Gaku, Kudo, Takashi, Matsuura, Yoshiharu, Fukumori, Akio, Takeda, Masatoshi, Ihara, Yasuo, Okochi, Masayasu

Volltext

Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1 von Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Ikuta, Akiko, Fukumori, Akio, Matsumoto, Naohiko, Ishizuka-Katsura, Yoshiko, Nakayama, Taisuke, Itoh, Naohiro, Jiang, Jingwei, Nishitomi, Kouhei, Kamino, Kouzin, Morihara, Takashi, Hashimoto, Ryota, Tanaka, Toshihisa, Kudo, Takashi, Chiba, Shigeru, Takeda, Masatoshi

Volltext

Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier von Morihara, Takashi, Hayashi, Noriyuki, Yokokoji, Mikiko, Akatsu, Hiroyasu, Silverman, Michael A., Kimura, Nobuyuki, Sato, Masahiro, Saito, Yuhki, Suzuki, Toshiharu, Yanagida, Kanta, Kodama, Takashi S., Tanaka, Toshihisa, Okochi, Masayasu, Tagami, Shinji, Kazui, Hiroaki, Kudo, Takashi, Hashimoto, Ryota, Itoh, Naohiro, Nishitomi, Kouhei, Yamaguchi-Kabata, Yumi, Tsunoda, Tatsuhiko, Takamura, Hironori, Katayama, Taiichi, Kimura, Ryo, Kamino, Kouzin, Hashizume, Yoshio, Takeda, Masatoshi

Volltext

Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration von Takata, Kazuyuki, Hirata-Fukae, Chiho, Becker, Amanda G., Chishiro, Saori, Gray, Audrey J., Nishitomi, Kouhei, Franz, Andreas H., Sakaguchi, Gaku, Kato, Akira, Mattson, Mark P., LaFerla, Frank M., Aisen, Paul S., Kitamura, Yoshihisa, Matsuoka, Yasuji

Volltext

Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α2A-adrenergic receptors in rats von Nishitomi, Kouhei, Yano, Koji, Kobayashi, Mika, Jino, Kohei, Kano, Takuya, Horiguchi, Naotaka, Shinohara, Shunji, Hasegawa, Minoru

Volltext

Systemic administration of guanfacine improves food-motivated impulsive choice behavior primarily via direct stimulation of postsynaptic α 2A -adrenergic receptors in rats von Nishitomi, Kouhei, Yano, Koji, Kobayashi, Mika, Jino, Kohei, Kano, Takuya, Horiguchi, Naotaka, Shinohara, Shunji, Hasegawa, Minoru

Volltext

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease von Kimura, Ryo, Kamino, Kouzin, Yamamoto, Mitsuko, Nuripa, Aidaralieva, Kida, Tomoyuki, Kazui, Hiroaki, Hashimoto, Ryota, Tanaka, Toshihisa, Kudo, Takashi, Yamagata, Hidehisa, Tabara, Yasuharu, Miki, Tetsuro, Akatsu, Hiroyasu, Kosaka, Kenji, Funakoshi, Eishi, Nishitomi, Kouhei, Sakaguchi, Gaku, Kato, Akira, Hattori, Hideyuki, Uema, Takeshi, Takeda, Masatoshi

Volltext

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor von Itoh, Naohiro, Okochi, Masayasu, Tagami, Shinji, Nishitomi, Kouhei, Nakayama, Taisuke, Yanagida, Kanta, Fukumori, Akio, Jiang, Jingwei, Mori, Kohji, Hosono, Motoko, Kikuchi, Jyunko, Nakano, Yuko, Takinami, Yoshihiko, Dohi, Keiji, Nishigaki, Atsuko, Takemoto, Hiroshi, Minagawa, Kazuyuki, Katoh, Takaaki, Willem, Michael, Haass, Christian, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Hasegawa, Hiroshi, Nishimura, Masaki, Sakaguchi, Gaku, Kato, Akira, Takeda, Masatoshi

Volltext

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2 von Nishitomi, Kouhei, Sakaguchi, Gaku, Horikoshi, Yuko, Gray, Audrey J., Maeda, Masahiro, Hirata‐Fukae, Chiho, Becker, Amanda G., Hosono, Motoko, Sakaguchi, Isako, Minami, S. Sakura, Nakajima, Yoshihiro, Li, Hui‐Fang, Takeyama, Chie, Kihara, Tsuyoshi, Ota, Akinobu, Wong, Philip C., Aisen, Paul S., Kato, Akira, Kinoshita, Noriaki, Matsuoka, Yasuji

Volltext

PRECLINICAL MULTI-SPECIES PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF THE ORAL BACE INHIBITOR JNJ-54861911 von Ito, Hisanori, Yamakawa, Hidekuni, Nishitomi, Kouhei, Hosono, Motoko, Unemura, Chie, Azuma, Yuki, Ando, Azusa, Izumi, Takaya, Nakajima, Yoshihiro, Tsuji, Hiroki, Kihara, Tsuyoshi, Jacobs, Tom, Borghys, Herman, Koriyama, Yuji, Kato, Akira, Sakaguchi, Gaku

Volltext

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice von NISHITOMI, Kouhei, SAKAGUCHI, Gaku, NAKAJIMA, Yoshihiro, LI, Hui-Fang, TAKEYAMA, Chie, KIHARA, Tsuyoshi, OTA, Akinobu, WONG, Philip C, AISEN, Paul S, KATO, Akira, KINOSHITA, Noriaki, MATSUOKA, Yasuji, HORIKOSHI, Yuko, GRAY, Audrey J, MAEDA, Masahiro, HIRATA-FUKAE, Chiho, BECKER, Amanda G, HOSONO, Motoko, SAKAGUCHI, Isako, SAKURA MINAMI, S

Volltext

Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-[Beta] accumulation modifier von Morihara, Takashi, Hayashi, Noriyuki, Yokokoji, Mikiko, Akatsu, Hiroyasu, Silverman, Michael A, Kimura, Nobuyuki, Sato, Masahiro, Saito, Yuhki, Suzuki, Toshiharu, Yanagida, Kanta, Kodama, Takashi S, Tanaka, Toshihisa, Okochi, Masayasu, Tagami, Shinji, Kazui, Hiroaki, Kudo, Takashi, Hashimoto, Ryota, Itoh, Naohiro, Nishitomi, Kouhei, Yamaguchi-Kabata, Yumi, Tsunoda, Tatsuhiko, Takamura, Hironori, Katayama, Taiichi, Kimura, Ryo, Kamino, Kouzin, Hashizume, Yoshio, Takeda, Masatoshi

Volltext

Levels of the surrogate marker for Aβ42 (i.e., APL1β) in CSF of sporadicAlzheimer disease patients increase before the onset of its clinical symptoms von Yanagida, Kanta, Okochi, Masayasu, Tagami, Shinji, Nakayama, Taisuke, Kodama, Takashi S., Nishitomi, Kouhei, Jiang, Jingwei, Mori, Kohji, Tatsumi, Shin-ichi, Kazui, Hiroaki, Tanaka, Toshihisa, Morihara, Takashi, Hashimoto, Ryota, Kudo, Takashi, Takeda, Masatoshi

Volltext

Novel APLP1 Peptide In CSF Is Useful For Diagnosis Of Sporadic Alzheimer's Disease von Okochi, Masayasu, Tagami, Shinji, Yanagida, Kanta, Nishitomi, Kouhei, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Tokuda, Takahiro, Kondo, Masaki, Ikeda, Masaki, Deguchi, Kentaro, Steiner, Harald, Haass, Christian, Kuwano, Ryozo, Takeda, Masatoshi

Volltext

P4‐296: Novel APLP1 Peptide In CSF Is Useful For Diagnosis Of Sporadic Alzheimer's Disease von Okochi, Masayasu, Tagami, Shinji, Yanagida, Kanta, Nishitomi, Kouhei, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Tokuda, Takahiro, Kondo, Masaki, Ikeda, Masaki, Deguchi, Kentaro, Steiner, Harald, Haass, Christian, Kuwano, Ryozo, Takeda, Masatoshi

Volltext

Analysis of an Aβ-like peptide in CSF to reveal whether and how the cleavage precision of presenilin/γ-secretase is altered in AD patients von Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Nakayama, Taisuke, Kodama, Takashi, Nishitomi, Kouhei, Tatsumi, Shin-Ichi, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Ikeda, Masaki, Deguchi, Kentaro, Kazui, Hiroaki, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Tsuchiya, Kuniaki, Akiyama, Haruhiko, Kuwano, Ryozou, Takeda, Masatoshi

Volltext

P1‐171: Analysis of an Aβ‐like peptide in CSF to reveal whether and how the cleavage precision of presenilin/γ‐secretase is altered in AD patients von Tagami, Shinji, Okochi, Masayasu, Yanagida, Kanta, Nakayama, Taisuke, Kodama, Takashi, Nishitomi, Kouhei, Tatsumi, Shin‐Ichi, Arai, Tetsuaki, Ikeuchi, Takeshi, Kasuga, Kensaku, Ikeda, Masaki, Deguchi, Kentaro, Kazui, Hiroaki, Morihara, Takashi, Tanaka, Toshihisa, Kudo, Takashi, Tsuchiya, Kuniaki, Akiyama, Haruhiko, Kuwano, Ryozou, Takeda, Masatoshi

Volltext

P3-339: Characteristics of membrane-bound factors affecting presenilin/γ-secretase cleavages von Mori, Kohji K, Okochi, Masayasu, Tagami, Shinji, Yanagida, Kanta, Nakayama, Taisuke, Nishitomi, Kouhei, Jiang, Jingwei, Tatsumi, Shinichi, Kodama, Takashi, Fukumori, Akio, Takeda, Masatoshi

Volltext

P2-366: Inhibition of Aβ production without perturbing Notch and Neuregulin signaling von Tatsumi, Shinichi, Okochi, Masayasu, Tagami, Shinji, Itoh, Naohiro, Nishitomi, Kouhei, Jiang, Jingwei, Nakayama, Taisuke, Yanagida, Kanta, Kodama, Takashi S, Mori, Kohji, Oguri, Takashi, Takeda, Masatoshi

Volltext