Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer von Freeman-Cook, Kevin D, Hoffman, Robert L, Behenna, Douglas C, Boras, Britton, Carelli, Jordan, Diehl, Wade, Ferre, Rose Ann, He, You-Ai, Hui, Andrea, Huang, Buwen, Huser, Nanni, Jones, Rhys, Kephart, Susan E, Lapek, John, McTigue, Michele, Miller, Nichol, Murray, Brion W, Nagata, Asako, Nguyen, Lisa, Niessen, Sherry, Ninkovic, Sacha, O’Doherty, Inish, Ornelas, Martha A, Solowiej, James, Sutton, Scott C, Tran, Khanh, Tseng, Elaine, Visswanathan, Ravi, Xu, Meirong, Zehnder, Luke, Zhang, Qin, Zhang, Cathy, Dann, Stephen

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Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1 von Blasina, Alessandra, Hallin, Jill, Chen, Enhong, Arango, Maria Elena, Kraynov, Eugenia, Register, James, Grant, Stephan, Ninkovic, Sacha, Chen, Ping, Nichols, Tim, O'Connor, Patrick, Anderes, Kenna

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Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors von Kung, Pei-Pei, Rui, Eugene, Bergqvist, Simon, Bingham, Patrick, Braganza, John, Collins, Michael, Cui, Mei, Diehl, Wade, Dinh, Dac, Fan, Connie, Fantin, Valeria R, Gukasyan, Hovhannes J, Hu, Wenyue, Huang, Buwen, Kephart, Susan, Krivacic, Cody, Kumpf, Robert A, Li, Gary, Maegley, Karen A, McAlpine, Indrawan, Nguyen, Lisa, Ninkovic, Sacha, Ornelas, Martha, Ryskin, Michael, Scales, Stephanie, Sutton, Scott, Tatlock, John, Verhelle, Dominique, Wang, Fen, Wells, Peter, Wythes, Martin, Yamazaki, Shinji, Yip, Brian, Yu, Xiu, Zehnder, Luke, Zhang, Wei-Guo, Rollins, Robert A, Edwards, Martin

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Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor von Freeman-Cook, Kevin, Hoffman, Robert L., Miller, Nichol, Almaden, Jonathan, Chionis, John, Zhang, Qin, Eisele, Koleen, Liu, Chaoting, Zhang, Cathy, Huser, Nanni, Nguyen, Lisa, Costa-Jones, Cinthia, Niessen, Sherry, Carelli, Jordan, Lapek, John, Weinrich, Scott L., Wei, Ping, McMillan, Elizabeth, Wilson, Elizabeth, Wang, Tim S., McTigue, Michele, Ferre, Rose Ann, He, You-Ai, Ninkovic, Sacha, Behenna, Douglas, Tran, Khanh T., Sutton, Scott, Nagata, Asako, Ornelas, Martha A., Kephart, Susan E., Zehnder, Luke R., Murray, Brion, Xu, Meirong, Solowiej, James E., Visswanathan, Ravi, Boras, Britton, Looper, David, Lee, Nathan, Bienkowska, Jadwiga R., Zhu, Zhou, Kan, Zhengyan, Ding, Ying, Mu, Xinmeng Jasmine, Oderup, Cecilia, Salek-Ardakani, Shahram, White, Michael A., VanArsdale, Todd, Dann, Stephen G.

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5-Bromo-1H-thieno[2,3-d]imidazole von Wang, Fen, Ninkovic, Sacha, Collins, Michael, Moore, Curtis, Rheingold, Arnold L, Yanovsky, Alex

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Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain von Bagal, Sharan K, Andrews, Mark, Bechle, Bruce M, Bian, Jianwei, Bilsland, James, Blakemore, David C, Braganza, John F, Bungay, Peter J, Corbett, Matthew S, Cronin, Ciaran N, Cui, Jingrong Jean, Dias, Rebecca, Flanagan, Neil J, Greasley, Samantha E, Grimley, Rachel, James, Kim, Johnson, Eric, Kitching, Linda, Kraus, Michelle L, McAlpine, Indrawan, Nagata, Asako, Ninkovic, Sacha, Omoto, Kiyoyuki, Scales, Stephanie, Skerratt, Sarah E, Sun, Jianmin, Tran-Dubé, Michelle, Waldron, Gareth J, Wang, Fen, Warmus, Joseph S

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A simple and convenient two-step, one-pot synthesis of hetero-imidazoles from nitroaminoaryls catalyzed by Ytterbium triflate von Wang, Fen, Tran-Dubé, Michelle, Scales, Stephanie, Johnson, Sarah, McAlpine, Indrawan, Ninkovic, Sacha

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Improved cyclization conditions to prepare 6-substituted pyrazolo[1,5-a]pyridines and pyrazolo[1,5-a]pyrazines using catalytic Ag(I) and Au(III) salts von Braganza, John F., Bernier, Louise, Botrous, Iriny, Collins, Michael R., Li, Baohua, McAlpine, Indrawan, Ninkovic, Sacha, Ren, Shijian, Sach, Neal, Tran-Dubé, Michelle, Zeng, Qingbin, Zheng, Baojiang

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Effect of water solvation on the lipophilicity of isomeric pyrimidine-carboxamides von Linton, Maria Angelica, Burke, Benjamin J., Johnson, Ted W., Ninkovic, Sacha, Gajiwala, Ketan S., Richardson, Paul, Le, Phuong T.

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The Synthesis of 3-pyrazinyl-pyrazolo [1,5-a] pyridines from an enol ether von Tran-Dubé, Michelle, Sach, Neal, Ninkovic, Sacha, Braganza, John F., Huang, Qinhua, Johnson, Benjamin, Collins, Michael Raymond

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Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{... von Zehnder, Luke, Bennett, Michael, Meng, Jerry, Huang, Buwen, Ninkovic, Sacha, Wang, Fen, Braganza, John, Tatlock, John, Jewell, Tanya, Zhou, Joe Zhongxiang, Burke, Ben, Wang, Jeff, Maegley, Karen, Mehta, Pramod P, Yin, Min-Jean, Gajiwala, Ketan S, Hickey, Michael J, Yamazaki, Shinji, Smith, Evan, Kang, Ping, Sistla, Anand, Dovalsantos, Elena, Gehring, Michael R, Kania, Robert, Wythes, Martin, Kung, Pei-Pei

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Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design von Cheng, Hengmiao, Bagrodia, Shubha, Bailey, Simon, Edwards, Martin, Hoffman, Jacqui, Hu, Qiyue, Kania, Robert, Knighton, Daniel R., Marx, Matthew A., Ninkovic, Sacha, Sun, Shaoxian, Zhang, Eric

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Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR von Le, Phuong T., Cheng, Hengmiao, Ninkovic, Sacha, Plewe, Michael, Huang, Xiaojun, Wang, Hai, Bagrodia, Shubha, Sun, Shaoxian, Knighton, Daniel R., LaFleur Rogers, Caroline M., Pannifer, Andrew, Greasley, Samantha, Dalvie, Deepak, Zhang, Eric

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Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors von Kung, Pei-Pei, Rui, Eugene, Bergqvist, Simon, Bingham, Patrick, Braganza, John, Collins, Michael, Cui, Mei, Diehl, Wade, Dinh, Dac, Fan, Connie, Fantin, Valeria R, Gukasyan, Hovhannes J, Hu, Wenyue, Huang, Buwen, Kephart, Susan, Krivacic, Cody, Kumpf, Robert A, Li, Gary, Maegley, Karen A, McAlpine, Indrawan, Nguyen, Lisa, Ninkovic, Sacha, Ornelas, Martha, Ryskin, Michael, Scales, Stephanie, Sutton, Scott, Tatlock, John, Verhelle, Dominique, Wang, Fen, Wells, Peter, Wythes, Martin, Yamazaki, Shinji, Yip, Brian, Yu, Xiu, Zehnder, Luke, Zhang, Wei-Guo, Rollins, Robert A, Edwards, Martin

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Stereoselective Synthesis of (−)-α-Kainic Acid and (+)-α-Allokainic Acid via Trimethylstannyl-Mediated Radical Carbocyclization and Oxidative Destannylation von Hanessian, Stephen, Ninkovic, Sacha

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Structure-Based Design of (5-Arylamino-2H-pyrazol-3-yl)-biphenyl-2‘,4‘-diols as Novel and Potent Human CHK1 Inhibitors von Teng, Min, Zhu, Jinjiang, Johnson, Michael D, Chen, Ping, Kornmann, Jill, Chen, Enhong, Blasina, Alessandra, Register, James, Anderes, Kenna, Rogers, Caroline, Deng, Yali, Ninkovic, Sacha, Grant, Stephan, Hu, Qiyue, Lundgren, Karen, Peng, Zhengwei, Kania, Robert S

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Corrigendum to “Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR” [Bioorg. Med. Chem. Lett. 22 (2012) 5098–5103]... von Le, Phuong T., Cheng, Hengmiao, Ninkovic, Sacha, Plewe, Michael, Huang, Xiaojun, Wang, Hai, Bagrodia, Shubha, Sun, Shaoxian, Knighton, Daniel R., LaFleur Rogers, Caroline M., Pannifer, Andrew, Greasley, Samantha, Dalvie, Deepak, Zhang, Eric

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4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors von Liu, Kevin K.-C., Bagrodia, Shubha, Bailey, Simon, Cheng, Hengmiao, Chen, Hui, Gao, Lisa, Greasley, Samantha, Hoffman, Jacqui E., Hu, Qiyue, Johnson, Ted O., Knighton, Dan, Liu, Zhengyu, Marx, Matthew A., Nambu, Mitchell D., Ninkovic, Sacha, Pascual, Bernadette, Rafidi, Kristina, Rodgers, Caroline M.-L., Smith, Graham L., Sun, Shaoxian, Wang, Haitao, Yang, Anle, Yuan, Jing, Zou, Aihua

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Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{... von Zehnder, Luke, Bennett, Michael, Meng, Jerry, Huang, Buwen, Ninkovic, Sacha, Wang, Fen, Braganza, John, Tatlock, John, Jewell, Tanya, Zhou, Joe Zhongxiang, Burke, Ben, Wang, Jeff, Maegley, Karen, Mehta, Pramod P., Yin, Min-Jean, Gajiwala, Ketan S., Hickey, Michael J., Yamazaki, Shinji, Smith, Evan, Kang, Ping, Sistla, Anand, Dovalsantos, Elena, Gehring, Michael R., Kania, Robert, Wythes, Martin, Kung, Pei-Pei

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Abstract 5779: The discovery of the potent and selective PI3K/mTOR dual inhibitor PF-04691502 through structure-based drug design von Cheng, Henry, Bagrodia, Shubha, Bailey, Simon, Bhumalkar, Dilip, Dress, Klaus, Edwards, Martin, Gehring, Michael R., Guo, Lisa, Hoffman, Jacqui, Hu, Qiyue, Huang, Xiaojun, Johnson, Catherine, Johnson, Ted O., Kania, Robert, Knighton, Daniel R., Le, Phuong, Li, Haitao, Li, Samuel, Liu, Kevin, Liu, Zhengyu, Marx, Matthew A., Nambu, Mitch, Ninkovic, Sacha, Nowlin, Dawn, Pairish, Mason, Pannifer, Andrew, Plewe, Michael, Rodgers, Caroline, Smith, Graham, Sun, Shaoxian, Tran, Khanh, Wang, Hai, Zbieg, Jason, Zhu, Peter

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