Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding von Verteramo, Maria Luisa, Stenström, Olof, Ignjatović, Majda Misini, Caldararu, Octav, Olsson, Martin A, Manzoni, Francesco, Leffler, Hakon, Oksanen, Esko, Logan, Derek T, Nilsson, Ulf J, Ryde, Ulf, Akke, Mikael

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Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease von Boza-Serrano, Antonio, Ruiz, Rocío, Sanchez-Varo, Raquel, García-Revilla, Juan, Yang, Yiyi, Jimenez-Ferrer, Itzia, Paulus, Agnes, Wennström, Malin, Vilalta, Anna, Allendorf, David, Davila, Jose Carlos, Stegmayr, John, Jiménez, Sebastian, Roca-Ceballos, Maria A., Navarro-Garrido, Victoria, Swanberg, Maria, Hsieh, Christine L., Real, Luis M., Englund, Elisabet, Linse, Sara, Leffler, Hakon, Nilsson, Ulf J., Brown, Guy C., Gutierrez, Antonia, Vitorica, Javier, Venero, Jose Luis, Deierborg, Tomas

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Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3 von MACKINNON, Alison C, GIBBONS, Michael A, SETHI, Tariq, FARNWORTH, Sarah L, LEFFLER, Hakon, NILSSON, Uif J, DELAINE, Tamara, JOHN SIMPSON, A, FORBES, Stuart J, HIRANI, Nik, GAULDIE, Jack

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Novel Selective Galectin‑3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia von Bum-Erdene, Khuchtumur, Collins, Patrick M, Hugo, Matthew W, Tarighat, Somayeh S, Fei, Fei, Kishor, Chandan, Leffler, Hakon, Nilsson, Ulf. J, Groffen, John, Grice, I. Darren, Heisterkamp, Nora, Blanchard, Helen

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Ligand Induced Galectin-3 Protein Self-association von Lepur, Adriana, Salomonsson, Emma, Nilsson, Ulf J., Leffler, Hakon

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Extracellular and intracellular small-molecule galectin-3 inhibitors von Stegmayr, John, Zetterberg, Fredrik, Carlsson, Michael C., Huang, Xiaoli, Sharma, Gunjan, Kahl-Knutson, Barbro, Schambye, Hans, Nilsson, Ulf J., Oredsson, Stina, Leffler, Hakon

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Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3 von Diehl, Carl, Engström, Olof, Delaine, Tamara, Håkansson, Maria, Genheden, Samuel, Modig, Kristofer, Leffler, Hakon, Ryde, Ulf, Nilsson, Ulf J, Akke, Mikael

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The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics von Saraboji, Kadhirvel, Håkansson, Maria, Genheden, Samuel, Diehl, Carl, Qvist, Johan, Weininger, Ulrich, Nilsson, Ulf J, Leffler, Hakon, Ryde, Ulf, Akke, Mikael, Logan, Derek T

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Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C von Wallerstein, Johan, Ekberg, Vilhelm, Ignjatović, Majda Misini, Kumar, Rohit, Caldararu, Octav, Peterson, Kristoffer, Wernersson, Sven, Brath, Ulrika, Leffler, Hakon, Oksanen, Esko, Logan, Derek T., Nilsson, Ulf J., Ryde, Ulf, Akke, Mikael

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Regulation of Alternative Macrophage Activation by Galectin-3 von MacKinnon, Alison C, Farnworth, Sarah L, Hodkinson, Philip S, Henderson, Neil C, Atkinson, Kirsten M, Leffler, Hakon, Nilsson, Ulf J, Haslett, Christopher, Forbes, Stuart J, Sethi, Tariq

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Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3 von Chen, Wei-Sheng, Cao, Zhiyi, Sugaya, Satoshi, Lopez, Maria J., Sendra, Victor G., Laver, Nora, Leffler, Hakon, Nilsson, Ulf J., Fu, Jianxin, Song, Jianhua, Xia, Lijun, Hamrah, Pedram, Panjwani, Noorjahan

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A Selective Galactose–Coumarin-Derived Galectin‑3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model von Rajput, Vishal K, MacKinnon, Alison, Mandal, Santanu, Collins, Patrick, Blanchard, Helen, Leffler, Hakon, Sethi, Tariq, Schambye, Hans, Mukhopadhyay, Balaram, Nilsson, Ulf J

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Structural characterization of human galectin‐4 C‐terminal domain: elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antig... von Bum‐Erdene, Khuchtumur, Leffler, Hakon, Nilsson, Ulf J, Blanchard, Helen

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Galectin‐3 type‐C self‐association on neutrophil surfaces; The carbohydrate recognition domain regulates cell function von Sundqvist, Martina, Welin, Amanda, Elmwall, Jonas, Osla, Veronica, Nilsson, Ulf J., Leffler, Hakon, Bylund, Johan, Karlsson, Anna

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Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site von Wahlgren, Weixiao Y., Dunevall, Elin, North, Rachel A., Paz, Aviv, Scalise, Mariafrancesca, Bisignano, Paola, Bengtsson-Palme, Johan, Goyal, Parveen, Claesson, Elin, Caing-Carlsson, Rhawnie, Andersson, Rebecka, Beis, Konstantinos, Nilsson, Ulf J., Farewell, Anne, Pochini, Lorena, Indiveri, Cesare, Grabe, Michael, Dobson, Renwick C. J., Abramson, Jeff, Ramaswamy, S., Friemann, Rosmarie

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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1 von Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.

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Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model von Stannard, Kimberley A, Collins, Patrick M, Ito, Koichi, Sullivan, Emily M, Scott, Stacy A, Gabutero, Elwyn, Darren Grice, I, Low, Pauline, Nilsson, Ulf. J, Leffler, Hakon, Blanchard, Helen, Ralph, Stephen J

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Development of a novel AAK1 inhibitor via Kinobeads-based screening von Yoshida, Akari, Ohtsuka, Satomi, Matsumoto, Fumiya, Miyagawa, Tomoyuki, Okino, Rei, Ikeda, Yumeya, Tada, Natsume, Gotoh, Akira, Magari, Masaki, Hatano, Naoya, Morishita, Ryo, Satoh, Ayano, Sunatsuki, Yukinari, Nilsson, Ulf J., Ishikawa, Teruhiko, Tokumitsu, Hiroshi

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Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin‑3 over Galectin‑1 von van Hattum, Hilde, Branderhorst, Hilbert M, Moret, Ed E, Nilsson, Ulf J, Leffler, Hakon, Pieters, Roland J

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Double Affinity Amplification of Galectin-Ligand Interactions through Arginine-Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido Thiodig... von Cumpstey, Ian, Salomonsson, Emma, Sundin, Anders, Leffler, Hakon, Nilsson, Ulf J.

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