Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase von RABINDRAN, Sridhar K, DISCAFANI, Carolyn M, REICH, Marvin F, RU SHEN, XIAOQING SHI, TSOU, Hwei-Ru, WANG, Yu-Fen, WISSNER, Allan, ROSFJORD, Edward C, BAXTER, Michelle, FLOYD, M. Brawner, GOLAS, Jonathan, HALLETT, William A, JOHNSON, Bernard D, NILAKANTAN, Ramaswamy, OVERBEEK, Elsebe

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Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity von Tsou, Hwei-Ru, Overbeek-Klumpers, Elsebe G, Hallett, William A, Reich, Marvin F, Floyd, M. Brawner, Johnson, Bernard D, Michalak, Ronald S, Nilakantan, Ramaswamy, Discafani, Carolyn, Golas, Jonathan, Rabindran, Sridhar K, Shen, Ru, Shi, Xiaoqing, Wang, Yu-Fen, Upeslacis, Janis, Wissner, Allan

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Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90 von Gopalsamy, Ariamala, Shi, Mengxiao, Golas, Jennifer, Vogan, Erik, Jacob, Jaison, Johnson, Mark, Lee, Frederick, Nilakantan, Ramaswamy, Petersen, Roseann, Svenson, Kristin, Chopra, Rajiv, Tam, May S, Wen, Yingxia, Ellingboe, John, Arndt, Kim, Boschelli, Frank

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Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinas... von Wissner, Allan, Overbeek, Elsebe, Reich, Marvin F, Floyd, M. Brawner, Johnson, Bernard D, Mamuya, Nellie, Rosfjord, Edward C, Discafani, Carolyn, Davis, Rachel, Shi, Xiaoqing, Rabindran, Sridhar K, Gruber, Brian C, Ye, Fei, Hallett, William A, Nilakantan, Ramaswamy, Shen, Ru, Wang, Yu-Fen, Greenberger, Lee M, Tsou, Hwei-Ru

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Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design von Chen, James M, Nelson, Frances C, Levin, Jeremy I, Mobilio, Dominick, Moy, Franklin J, Nilakantan, Ramaswamy, Zask, Arie, Powers, Robert

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Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin von Plotch, S J, O'Hara, B, Morin, J, Palant, O, LaRocque, J, Bloom, J D, Lang, Jr, S A, DiGrandi, M J, Bradley, M, Nilakantan, R, Gluzman, Y

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Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles von Wissner, Allan, Hamann, Philip R., Nilakantan, Ramaswamy, Greenberger, Lee M., Ye, Fei, Rapuano, Timothy A., Loganzo, Frank

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MultiMCS: A Fast Algorithm for the Maximum Common Substructure Problem on Multiple Molecules von Hariharan, Ramesh, Janakiraman, Anand, Nilakantan, Ramaswamy, Singh, Bhupender, Varghese, Sajith, Landrum, Gregory, Schuffenhauer, Ansgar

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An Efficient Synthesis of Dibenzo[c,f]-2,7-naphthyridine Ring System through Design of Experiments von Gopalsamy, Ariamala, Shi, Mengxiao, Nilakantan, Ramaswamy

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6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-... von Tsou, Hwei-Ru, Mamuya, Nellie, Johnson, Bernard D, Reich, Marvin F, Gruber, Brian C, Ye, Fei, Nilakantan, Ramaswamy, Shen, Ru, Discafani, Carolyn, DeBlanc, Ronald, Davis, Rachel, Koehn, Frank E, Greenberger, Lee M, Wang, Yu-Fen, Wissner, Allan

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4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4) von Tsou, Hwei-Ru, Otteng, Mercy, Tran, Tritin, Floyd, M. Brawner, Reich, Marvin, Birnberg, Gary, Kutterer, Kristina, Ayral-Kaloustian, Semiramis, Ravi, Malini, Nilakantan, Ramaswamy, Grillo, Mary, McGinnis, John P, Rabindran, Sridhar K

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Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design von Tsao, Désirée H.H., Sutherland, Alan G., Jennings, Lee. D., Li, Yuanhong, Rush, Thomas S., Alvarez, Juan C., Ding, Weidong, Dushin, Elizabeth G., Dushin, Russell G., Haney, Steve A., Kenny, Cynthia H., Karl Malakian, A., Nilakantan, Ramaswamy, Mosyak, Lidia

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The ensemble approach to distance geometry: application to the nicotinic pharmacophore von Sheridan, Robert P, Nilakantan, Ramaswamy, Dixon, J. Scott, Venkataraghavan, R

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2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2 von Wissner, Allan, Floyd, M. Brawner, Johnson, Bernard D, Fraser, Heidi, Ingalls, Charles, Nittoli, Thomas, Dushin, Russell G, Discafani, Carolyn, Nilakantan, Ramaswamy, Marini, Joseph, Ravi, Malini, Cheung, Kinwang, Tan, Xingzhi, Musto, Sylvia, Annable, Tami, Siegel, Marshall M, Loganzo, Frank

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4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline In... von Wissner, Allan, Berger, Dan M, Boschelli, Diane H, Floyd, M. Brawner, Greenberger, Lee M, Gruber, Brian C, Johnson, Bernard D, Mamuya, Nellie, Nilakantan, Ramaswamy, Reich, Marvin F, Shen, Ru, Tsou, Hwei-Ru, Upeslacis, Erik, Wang, Yu Fen, Wu, Biqi, Ye, Fei, Zhang, Nan

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CONFIRM: connecting fragments found in receptor molecules von Thompson, David C., Aldrin Denny, R., Nilakantan, Ramaswamy, Humblet, Christine, Joseph-McCarthy, Diane, Feyfant, Eric

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A structural informatics approach to mine kinase knowledge bases von Brooijmans, Natasja, Mobilio, Dominick, Walker, Gary, Nilakantan, Ramaswamy, Denny, Rajiah A., Feyfant, Eric, Diller, David, Bikker, Jack, Humblet, Christine

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A structural information approach to mine kinase knowledge bases von BROOIJMANS, Natasja, MOBILIO, Dominick, WALKER, Gary, NILAKANTAN, Ramaswamy, DENNY, Rajiah A, FEYFANT, Eric, DILLER, David, BIKKER, Jack, HUMBLET, Christine

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A Family of Ring System-Based Structural Fragments for Use in Structure−Activity Studies:  Database Mining and Recursive Partitioning von Nilakantan, Ramaswamy, Nunn, David S, Greenblatt, Lynne, Walker, Gary, Haraki, Kevin, Mobilio, Dominick

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A fresh look at pharmaceutical screening library design von Nilakantan, Ramaswamy, Nunn, David S.

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