Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR -Mutated Non-Small Cell Lung Cancer von Hirano, Toshiyuki, Yasuda, Hiroyuki, Hamamoto, Junko, Nukaga, Shigenari, Masuzawa, Keita, Kawada, Ichiro, Naoki, Katsuhiko, Niimi, Tatsuya, Mimasu, Shinya, Sakagami, Hideki, Soejima, Kenzo, Betsuyaku, Tomoko

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Structural basis for telmisartan-mediated partial activation of PPAR gamma von Amano, Yasushi, Yamaguchi, Tomohiko, Ohno, Kazuki, Niimi, Tatsuya, Orita, Masaya, Sakashita, Hitoshi, Takeuchi, Makoto

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Running-in friction of hip joint replacements can be significantly reduced: The effect of surface-textured acetabular cup von Nečas, David, Usami, Hatsuhiko, Niimi, Tatsuya, Sawae, Yoshinori, Křupka, Ivan, Hartl, Martin

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Discovery of a Novel Nicotinamide Phosphoribosyl Transferase (NAMPT) Inhibitor via in Silico Screening von Takeuchi, Mikio, Niimi, Tatsuya, Masumoto, Mari, Orita, Masaya, Yokota, Hiroyuki, Yamamoto, Tomoko

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In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease von Yoshino, Ryunosuke, Yasuo, Nobuaki, Hagiwara, Yohsuke, Ishida, Takashi, Inaoka, Daniel Ken, Amano, Yasushi, Tateishi, Yukihiro, Ohno, Kazuki, Namatame, Ichiji, Niimi, Tatsuya, Orita, Masaya, Kita, Kiyoshi, Akiyama, Yutaka, Sekijima, Masakazu

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NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes von Tani, Osamu, Akutsu, Yukie, Ito, Shinji, Suzuki, Takayuki, Tateishi, Yukihiro, Yamaguchi, Tomohiko, Niimi, Tatsuya, Namatame, Ichiji, Chiba, Yasunori, Sakashita, Hitoshi, Kubota, Tomomi, Yanagi, Tetsuo, Mizukami, Shusaku, Hirayama, Kenji, Furukawa, Koji, Yamasaki, Kazuhiko

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DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein-protein interactions von Ikeda, Kazuyoshi, Maezawa, Yuta, Yonezawa, Tomoki, Shimizu, Yugo, Tashiro, Toshiyuki, Kanai, Satoru, Sugaya, Nobuyoshi, Masuda, Yoshiaki, Inoue, Naoko, Niimi, Tatsuya, Masuya, Keiichi, Mizuguchi, Kenji, Furuya, Toshio, Osawa, Masanori

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Correction to NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes von Tani, Osamu, Akutsu, Yukie, Ito, Shinji, Suzuki, Takayuki, Tateishi, Yukihiro, Yamaguchi, Tomohiko, Niimi, Tatsuya, Namatame, Ichiji, Chiba, Yasunori, Sakashita, Hitoshi, Kubota, Tomomi, Yanagi, Tetsuo, Mizukami, Shusaku, Hirayama, Kenji, Furukawa, Koji, Yamasaki, Kazuhiko

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Fundamental research on Japanese language education and career path connectivity in ASEAN countries von Niimi, Tatsuya

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Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor von Ohno, Kazuki, Amano, Yasushi, Kakuta, Hirotoshi, Niimi, Tatsuya, Takakura, Shoji, Orita, Masaya, Miyata, Keiji, Sakashita, Hitoshi, Takeuchi, Makoto, Komuro, Issei, Higaki, Jitsuo, Horiuchi, Masatsugu, Kim-Mitsuyama, Shokei, Mori, Yutaka, Morishita, Ryuichi, Yamagishi, Sho-ichi

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Two ‘Golden Ratio’ indices in fragment-based drug discovery von Orita, Masaya, Ohno, Kazuki, Niimi, Tatsuya

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Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands von Miura, Masanori, Seki, Norio, Koike, Takanori, Ishihara, Tsukasa, Niimi, Tatsuya, Hirayama, Fukushi, Shigenaga, Takeshi, Sakai-Moritani, Yumiko, Tagawa, Ayako, Kawasaki, Tomihisa, Sakamoto, Shuichi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

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Structures of complexes of type 5 17β-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding von Amano, Yasushi, Yamaguchi, Tomohiko, Niimi, Tatsuya, Sakashita, Hitoshi

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Electron Transfer between a Photoexcited Azo Pigment Particle and an Electron Donor Molecule in a Solid System von Niimi, Tatsuya, Umeda, Minoru

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Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase von Amano, Yasushi, Namatame, Ichiji, Tateishi, Yukihiro, Honboh, Kazuya, Tanabe, Eiki, Niimi, Tatsuya, Sakashita, Hitoshi

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Lead generation and examples opinion regarding how to follow up hits von Orita, Masaya, Ohno, Kazuki, Warizaya, Masaichi, Amano, Yasushi, Niimi, Tatsuya

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An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi von Yamasaki, Kazuhiko, Tani, Osamu, Tateishi, Yukihiro, Tanabe, Eiki, Namatame, Ichiji, Niimi, Tatsuya, Furukawa, Koji, Sakashita, Hitoshi

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In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3) von Kikuchi, Aya, Furutani, Takashi, Azami, Hidenori, Watanabe, Kazushi, Niimi, Tatsuya, Kamiyama, Yoshiteru, Kuromitsu, Sadao, Baskin-Bey, Edwina, Heeringa, Marten, Ouatas, Taoufik, Enjo, Kentaro

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4‑Hydroxypyridazin-3(2H)‑one Derivatives as Novel d‑Amino Acid Oxidase Inhibitors von Hondo, Takeshi, Warizaya, Masaichi, Niimi, Tatsuya, Namatame, Ichiji, Yamaguchi, Tomohiko, Nakanishi, Keita, Hamajima, Toshihiro, Harada, Katsuya, Sakashita, Hitoshi, Matsumoto, Yuzo, Orita, Masaya, Takeuchi, Makoto

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Design and Synthesis of Non-peptidic Inhibitors for the Syk C-Terminal SH2 Domain Based on Structure-Based In-Silico Screening von Niimi, Tatsuya, Orita, Masaya, Okazawa-Igarashi, Miwa, Sakashita, Hitoshi, Kikuchi, Kazumi, Ball, Evelyn, Ichikawa, Atsushi, Yamagiwa, Yoko, Sakamoto, Shuichi, Tanaka, Akihiro, Tsukamoto, Shinichi, Fujita, Shigeo, Tatsuta, Kuniaki, Maeda, Yasuhide, Chikauchi, Ken

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