Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment von Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit

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A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target von Srivastava, Prashant K., van Eyll, Jonathan, Godard, Patrice, Mazzuferi, Manuela, Delahaye-Duriez, Andree, Van Steenwinckel, Juliette, Gressens, Pierre, Danis, Benedicte, Vandenplas, Catherine, Foerch, Patrik, Leclercq, Karine, Mairet-Coello, Georges, Cardenas, Alvaro, Vanclef, Frederic, Laaniste, Liisi, Niespodziany, Isabelle, Keaney, James, Gasser, Julien, Gillet, Gaelle, Shkura, Kirill, Chong, Seon-Ah, Behmoaras, Jacques, Kadiu, Irena, Petretto, Enrico, Kaminski, Rafal M., Johnson, Michael R.

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Comparative study of lacosamide and classical sodium channel blocking antiepileptic drugs on sodium channel slow inactivation von Niespodziany, Isabelle, Leclère, Nathalie, Vandenplas, Catherine, Foerch, Patrik, Wolff, Christian

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EFFECTS OF CHRONIC ANTI-SEIZURE MEDICATIONS IN AN ORGANOTYPIC HIPPOCAMPAL SLICE CULTURE MODEL OF EPILEPSY von Niespodziany, Isabelle, Frey, Aurore, Aguirre, Rodrigo, Szczesny, Grégory, Dedeurwaerdere, Stefanie

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Brivaracetam augments short‐term depression and slows vesicle recycling von Yang, Xiaofeng, Bognar, Joseph, He, Tianyu, Mohammed, Mouhari, Niespodziany, Isabelle, Wolff, Christian, Esguerra, Manuel, Rothman, Steven M., Dubinsky, Janet M.

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Brivaracetam Differentially Affects Voltage‐Gated Sodium Currents Without Impairing Sustained Repetitive Firing in Neurons von Niespodziany, Isabelle, André, Véronique Marie, Leclère, Nathalie, Hanon, Etienne, Ghisdal, Philippe, Wolff, Christian

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Levetiracetam inhibits the high-voltage-activated Ca2+ current in pyramidal neurones of rat hippocampal slices von NIESPODZIANY, Isabelle, KLITGAARD, Henrik, MARGINEANU, Doru Georg

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Activity of the anticonvulsant lacosamide in experimental and human epilepsy via selective effects on slow Na+ channel inactivation von Holtkamp, Dominik, Opitz, Thoralf, Niespodziany, Isabelle, Wolff, Christian, Beck, Heinz

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Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices von Niespodziany, Isabelle, Klitgaard, Henrik, Margineanu, Doru Georg

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Functional characterization of the antiepileptic drug candidate, padsevonil, on GABA A receptors von Niespodziany, Isabelle, Ghisdal, Philippe, Mullier, Brice, Wood, Martyn, Provins, Laurent, Kaminski, Rafal M, Wolff, Christian

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Brivaracetam does not modulate ionotropic channels activated by glutamate, γ‐aminobutyric acid, and glycine in hippocampal neurons von Niespodziany, Isabelle, Rigo, Jean‐Michel, Moonen, Gustave, Matagne, Alain, Klitgaard, Henrik, Wolff, Christian

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Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors von Niespodziany, Isabelle, Ghisdal, Philippe, Mullier, Brice, Wood, Martyn, Provins, Laurent, Kaminski, Rafal M., Wolff, Christian

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Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice von Venkatesan, Kumar, Alix, Philippe, Marquet, Alice, Doupagne, Melissa, Niespodziany, Isabelle, Rogister, Bernard, Seutin, Vincent

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Brivaracetam does not modulate ionotropic channels activated by glutamate, [gamma]-aminobutyric acid, and glycine in hippocampal neurons von Niespodziany, Isabelle, Rigo, Jean-Michel, Moonen, Gustave, Matagne, Alain, Klitgaard, Henrik, Wolff, Christian

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Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ curre... von Uebachs, Mischa, Albus, Christina, Opitz, Thoralf, Isom, Lori, Niespodziany, Isabelle, Wolff, Christian, Beck, Heinz

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Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices von Niespodziany, I, Klitgaard, H, Margineanu, D G

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Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model von Chong, Seon-Ah, Balosso, Silvia, Vandenplas, Catherine, Szczesny, Gregory, Hanon, Etienne, Claes, Kasper, Van Damme, Xavier, Danis, Bénédicte, Van Eyll, Jonathan, Wolff, Christian, Vezzani, Annamaria, Kaminski, Rafal M., Niespodziany, Isabelle

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Discovery of a small molecule modulator of the Kv1.1/Kvβ1 channel complex that reduces neuronal excitability and in vitro epileptiform activity von Niespodziany, Isabelle, Mullier, Brice, André, Véronique Marie, Ghisdal, Philippe, Jnoff, Eric, Moreno‐Delgado, David, Swinnen, Dominique, Sands, Zara, Wood, Martyn, Wolff, Christian

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Hippocampal slices from long-term streptozotocin-injected rats are prone to epileptiform responses von Margineanu, Doru Georg, Niespodziany, Isabelle, Wülfert, Ernst

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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV 2A ligand for epilepsy treatment von Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit

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