RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors von Su, Fei, Viros, Amaya, Milagre, Carla, Trunzer, Kerstin, Bollag, Gideon, Spleiss, Olivia, Reis-Filho, Jorge S, Kong, Xiangju, Koya, Richard C, Flaherty, Keith T, Chapman, Paul B, Kim, Min Jung, Hayward, Robert, Martin, Matthew, Yang, Hong, Wang, Qiongqing, Hilton, Holly, Hang, Julie S, Noe, Johannes, Lambros, Maryou, Geyer, Felipe, Dhomen, Nathalie, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Zambon, Alfonso, Preece, Natasha, Robert, Lídia, Otte, Nicholas J, Mok, Stephen, Kee, Damien, Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A, Wong, Bernice, Nguyen, Hoa, Kockx, Mark, Andries, Luc, Lestini, Brian, Nolop, Keith B, Lee, Richard J, Joe, Andrew K, Troy, James L, Gonzalez, Rene, Hutson, Thomas E, Puzanov, Igor, Chmielowski, Bartosz, Springer, Caroline J, McArthur, Grant A, Sosman, Jeffrey A, Lo, Roger S, Ribas, Antoni, Marais, Richard

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Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia von Packer, Leisl M., Rana, Sareena, Hayward, Robert, O'Hare, Thomas, Eide, Christopher A., Rebocho, Ana, Heidorn, Sonja, Zabriskie, Matthew S., Niculescu-Duvaz, Ion, Druker, Brian J., Springer, Caroline, Marais, Richard

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Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes von Pedersen, Malin, Küsters-Vandevelde, Heidi V N, Viros, Amaya, Groenen, Patricia J T A, Sanchez-Laorden, Berta, Gilhuis, Jacobus H, van Engen-van Grunsven, Ilse A, Renier, Willy, Schieving, Jolanda, Niculescu-Duvaz, Ion, Springer, Caroline J, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, Marais, Richard

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Small molecule inhibitors of BRAF in clinical trials von Zambon, Alfonso, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J

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Prodrug-activating systems in suicide gene therapy von Springer, C J, Niculescu-Duvaz, I

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Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents von Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Davies, Lawrence, Pons, Jean-Francois, Whittaker, Steven, Marais, Richard, Springer, Caroline J.

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Abstract LB-212: Therapeutic efficacy of the paradox-breaking panRAF and SRC drug CCT3833/BAL3833 in KRAS-driven cancer models von Saturno, Grazia, Lopes, Filipa, Girotti, Maria Romina, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Zambon, Alfonso, Davies, Lawrence, Johnson, Louise, Preece, Natasha, Viros, Amaya, Pedersen, Malin, McLeary, Robert, Knight, Ruth, Lee, Rebecca, Holovanchuk, Denys, Lorigan, Paul, Dhomen, Nathalie, Marais, Richard, Springer, Caroline

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A Phase 1 first-in-human trial to evaluate the safety and tolerability of CCT3833, an oral panRAF inhibitor, in patients with advanced solid tumours, including metastatic melanoma von Dean, Emma Jane, Banerji, Udai, Girotti, Romina, Niculescu-Duvaz, Ion, Lopes, Filipa, Davies, Lawrence, Niculescu-Duvaz, Dan, Dhomen, Natalie, Ellis, Sally, Ali, Zohra, O'Carrigan, Brent, Carter, Louise, Chisolm, Luke, Dive, Caroline, Lane, Heidi A, Lorigan, Paul, Gore, Martin Eric, Larkin, James, Marais, Richard, Springer, Caroline

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ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts von BLAKEY, D. C, BURKE, P. J, PINDER, P. E, SHARMA, S. K, WRIGHT, A. F, SPRINGER, C. J, DAVIES, D. H, DOWELL, R. I, EAST, S. J, ECKERSLEY, K. P, FITTON, J. E, MCDAID, J, MELTON, R. G, NICULESCU-DUVAZ, I. A

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Novel Hinge Binder Improves Activity and Pharmacokinetic Properties of BRAF Inhibitors von Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M, Niculescu-Duvaz, Ion, Whittaker, Steven, Niculescu-Duvaz, Dan, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A, Lopes, Filipa, Preece, Natasha, Hedley, Douglas, Ogilvie, Lesley M, Kirk, Ruth, Marais, Richard, Springer, Caroline J

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Introduction to the background, principles, and state of the art in suicide gene therapy von Niculescu-Duvaz, Ion, Springer, Caroline J

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Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring von Ménard, Delphine, Niculescu-Duvaz, Ion, Dijkstra, Harmen P, Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M, Zambon, Alfonso, Nourry, Arnaud, Roman, Esteban, Davies, Lawrence, Manne, Helen A, Friedlos, Frank, Kirk, Ruth, Whittaker, Steven, Gill, Adrian, Taylor, Richard D, Marais, Richard, Springer, Caroline J

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Novel Inhibitors of B-RAF Based on a Disubstituted Pyrazine Scaffold. Generation of a Nanomolar Lead von Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R, Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J, Davies, Lawrence C, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J

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Novel Inhibitors of the v-raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) Based on a 2,6-Disubstituted Pyrazine Scaffold von Niculescu-Duvaz, Ion, Roman, Esteban, Whittaker, Steven R, Friedlos, Frank, Kirk, Ruth, Scanlon, Ian J, Davies, Lawrence C, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J

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Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) von Niculescu-Duvaz, Dan, Gaulon, Catherine, Dijkstra, Harmen P, Niculescu-Duvaz, Ion, Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M, Nourry, Arnaud, Davies, Lawrence, Manne, Helen, Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Whittaker, Steven, Kirk, Ruth, Gill, Adrian, Taylor, Richard D, Raynaud, Florence I, Moreno-Farre, Javier, Marais, Richard, Springer, Caroline J

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Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromat... von Suijkerbuijk, Bart M. J. M, Niculescu-Duvaz, Ion, Gaulon, Catherine, Dijkstra, Harmen P, Niculescu-Duvaz, Dan, Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A, Friedlos, Frank, Ogilvie, Lesley M, Hedley, Douglas, Lopes, Filipa, Preece, Natasha P. U, Moreno-Farre, Javier, Raynaud, Florence I, Kirk, Ruth, Whittaker, Steven, Marais, Richard, Springer, Caroline J

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Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds von Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A., Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Takle, Andrew K., Wilson, David M., Pons, Jean-Francois, Coulter, Tom, Kirk, Ruth, Cantarino, Neus, Whittaker, Steven, Marais, Richard, Springer, Caroline J.

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BRAF Inhibitors Based on an Imidazo[4,5]pyridin-2-one Scaffold and a Meta Substituted Middle Ring von Nourry, Arnaud, Zambon, Alfonso, Davies, Lawrence, Niculescu-Duvaz, Ion, Dijkstra, Harmen P, Ménard, Delphine, Gaulon, Catherine, Niculescu-Duvaz, Dan, Suijkerbuijk, Bart M. J. M, Friedlos, Frank, Manne, Helen A, Kirk, Ruth, Whittaker, Steven, Marais, Richard, Springer, Caroline J

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The emerging fields of suicide gene therapy and virotherapy von Kirn, David, Niculescu-Duvaz, Ion, Hallden, Gunnel, Springer, Caroline J

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A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[ N, N-bis(2-hydroxyethyl)amino]phenyl chloroformate von Niculescu-Duvaz, Dan, Scanlon, Ian, Niculescu-Duvaz, Ion, Springer, Caroline J.

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