Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction von Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin

Volltext

A distal regulatory region of a class I human histone deacetylase von Werbeck, Nicolas D., Shukla, Vaibhav Kumar, Kunze, Micha B. A., Yalinca, Havva, Pritchard, Ruth B., Siemons, Lucas, Mondal, Somnath, Greenwood, Simon O. R., Kirkpatrick, John, Marson, Charles M., Hansen, D. Flemming

Volltext

Coupling and Dynamics of Subunits in the Hexameric AAA+ Chaperone ClpB von Werbeck, Nicolas D., Schlee, Sandra, Reinstein, Jochen

Volltext

Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction von Zeymer, Cathleen, Werbeck, Nicolas D., Zimmermann, Sabine, Reinstein, Jochen, Hansen, D. Flemming

Volltext

The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1 von Leskovar, Adriane, Wegele, Harald, Werbeck, Nicolas D., Buchner, Johannes, Reinstein, Jochen

Volltext

Probing Arginine Side-Chains and Their Dynamics with Carbon-Detected NMR Spectroscopy: Application to the 42 kDa Human Histone Deacetylase 8 at High pH von Werbeck, Nicolas D., Kirkpatrick, John, Hansen, D. Flemming

Volltext

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target von Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, Ter Laak, Antonius, Fernández-Montalván, Amaury E, Eberspaecher, Uwe, Werbeck, Nicolas D, Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L, Stresemann, Carlo

Volltext

The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride von Zeymer, Cathleen, Werbeck, Nicolas D., Schlichting, Ilme, Reinstein, Jochen

Volltext

Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein von Werbeck, Nicolas D, Itzhaki, Laura S

Volltext

Loop Interactions and Dynamics Tune the Enzymatic Activity of the Human Histone Deacetylase 8 von Kunze, Micha B. A, Wright, David W, Werbeck, Nicolas D, Kirkpatrick, John, Coveney, Peter V, Hansen, D. Flemming

Volltext

Identification of Small Molecules that Modulate Mutant p53 Condensation von Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick

Volltext

Coupling of Oligomerization and Nucleotide Binding in the AAA+ Chaperone ClpB von Werbeck, Nicolas D, Zeymer, Cathleen, Kellner, Julian N, Reinstein, Jochen

Volltext

Disaggregases in 4 dimensions von Barends, Thomas RM, Werbeck, Nicolas D, Reinstein, Jochen

Volltext

Shifting transition states in the unfolding of a large ankyrin repeat protein von Werbeck, Nicolas D, Rowling, Pamela J.E, Chellamuthu, Vasuki R, Itzhaki, Laura S

Volltext

Using 15N-Ammonium to Characterise and Map Potassium Binding Sites in Proteins by NMR Spectroscopy von Werbeck, Nicolas D., Kirkpatrick, John, Reinstein, Jochen, Hansen, D. Flemming

Volltext

Strategic Roles of Axial Histidines in Structure Formation and Redox Regulation of Tetraheme Cytochrome c3 von TAKAYAMA, Yuki, WERBECK, Nicolas D., KOMORI, Hirofumi, MORITA, Kumiko, OZAWA, Kiyoshi, HIGUCHI, Yoshiki, AKUTSU, Hideo

Volltext

Nucleotide Binding and Allosteric Modulation of the Second AAA+ Domain of ClpB Probed by Transient Kinetic Studies von Werbeck, Nicolas D, Kellner, Julian N, Barends, Thomas R. M, Reinstein, Jochen

Volltext

Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction von Zeymer, Cathleen, Werbeck, Nicolas D., Zimmermann, Sabine, Reinstein, Jochen, Hansen, D. Flemming

Volltext

Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor von Zeymer, Cathleen, Barends, Thomas R. M., Werbeck, Nicolas D., Schlichting, Ilme, Reinstein, Jochen

Volltext

Strategic Roles of Axial Histidines in Structure Formation and Redox Regulation of Tetraheme Cytochrome c 3 von Takayama, Yuki, Werbeck, Nicolas D, Komori, Hirofumi, Morita, Kumiko, Ozawa, Kiyoshi, Higuchi, Yoshiki, Akutsu, Hideo

Volltext