Reductive carboxylation supports redox homeostasis during anchorage-independent growth von Jiang, Lei, Shestov, Alexander A., Swain, Pamela, Yang, Chendong, Parker, Seth J., Wang, Qiong A., Terada, Lance S., Adams, Nicholas D., McCabe, Michael T., Pietrak, Beth, Schmidt, Stan, Metallo, Christian M., Dranka, Brian P., Schwartz, Benjamin, DeBerardinis, Ralph J.

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin von Knight, Steven D, Adams, Nicholas D, Burgess, Joelle L, Chaudhari, Amita M, Darcy, Michael G, Donatelli, Carla A, Luengo, Juan I, Newlander, Ken A, Parrish, Cynthia A, Ridgers, Lance H, Sarpong, Martha A, Schmidt, Stanley J, Van Aller, Glenn S, Carson, Jeffrey D, Diamond, Melody A, Elkins, Patricia A, Gardiner, Christine M, Garver, Eric, Gilbert, Seth A, Gontarek, Richard R, Jackson, Jeffrey R, Kershner, Kevin L, Luo, Lusong, Raha, Kaushik, Sherk, Christian S, Sung, Chiu-Mei, Sutton, David, Tummino, Peter J, Wegrzyn, Ronald J, Auger, Kurt R, Dhanak, Dashyant

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Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase von Adams, Nicholas D, Adams, Jerry L, Burgess, Joelle L, Chaudhari, Amita M, Copeland, Robert A, Donatelli, Carla A, Drewry, David H, Fisher, Kelly E, Hamajima, Toshihiro, Hardwicke, Mary Ann, Huffman, William F, Koretke-Brown, Kristin K, Lai, Zhihong V, McDonald, Octerloney B, Nakamura, Hiroko, Newlander, Ken A, Oleykowski, Catherine A, Parrish, Cynthia A, Patrick, Denis R, Plant, Ramona, Sarpong, Martha A, Sasaki, Kosuke, Schmidt, Stanley J, Silva, Domingos J, Sutton, David, Tang, Jun, Thompson, Christine S, Tummino, Peter J, Wang, Jamin C, Xiang, Hong, Yang, Jingsong, Dhanak, Dashyant

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Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss von Fedoriw, Andrew, Rajapurkar, Satyajit R., O'Brien, Shane, Gerhart, Sarah V., Mitchell, Lorna H., Adams, Nicholas D., Rioux, Nathalie, Lingaraj, Trupti, Ribich, Scott A., Pappalardi, Melissa B., Shah, Niyant, Laraio, Jenny, Liu, Yan, Butticello, Michael, Carpenter, Chris L., Creasy, Caretha, Korenchuk, Susan, McCabe, Michael T., McHugh, Charles F., Nagarajan, Raman, Wagner, Craig, Zappacosta, Francesca, Annan, Roland, Concha, Nestor O., Thomas, Roberta A., Hart, Timothy K., Smith, Jesse J., Copeland, Robert A., Moyer, Mikel P., Campbell, John, Stickland, Kim, Mills, James, Jacques-O’Hagan, Suzanne, Allain, Christina, Johnston, Danielle, Raimondi, Alejandra, Porter Scott, Margaret, Waters, Nigel, Swinger, Kerren, Boriack-Sjodin, Ann, Riera, Tom, Shapiro, Gideon, Chesworth, Richard, Prinjha, Rabinder K., Kruger, Ryan G., Barbash, Olena, Mohammad, Helai P.

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New IDH1 mutant inhibitors for treatment of acute myeloid leukemia von Okoye-Okafor, Ujunwa C, Bartholdy, Boris, Cartier, Jessy, Gao, Enoch N, Pietrak, Beth, Rendina, Alan R, Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J, Reif, Alexander J, Schmidt, Stanley J, Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-Rao, Antony-Debre, Iléana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D, Schwartz, Benjamin, McCabe, Michael T, Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich

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Total Synthesis of Bafilomycin V1:  A Methanolysis Product of the Macrolide Bafilomycin C2 von Marshall, James A., Adams, Nicholas D.

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Shortcut Method for Extraction of Staphylococcus aureus DNA from Blood Cultures and Conventional Cultures for Use in Real-Time PCR Assays von Adams, D. Nicholas

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Mutant IDH1 Enhances the Production of 2‑Hydroxyglutarate Due to Its Kinetic Mechanism von Rendina, Alan R, Pietrak, Beth, Smallwood, Angela, Zhao, Huizhen, Qi, Hongwei, Quinn, Chad, Adams, Nicholas D, Concha, Nestor, Duraiswami, Chaya, Thrall, Sara H, Sweitzer, Sharon, Schwartz, Benjamin

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Addition of Allenylzinc Reagents, Prepared in Situ from Nonracemic Propargylic Mesylates, to Aldehydes. A New Synthesis of Highly Enantioenriched Homopropargylic Alcohols von Marshall, James A, Adams, Nicholas D

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Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT) von Yang, Hongfang, Medeiros, Patricia F, Raha, Kaushik, Elkins, Patricia, Lind, Kenneth E, Lehr, Ruth, Adams, Nicholas D, Burgess, Joelle L, Schmidt, Stanley J, Knight, Steven D, Auger, Kurt R, Schaber, Michael D, Franklin, G. Joseph, Ding, Yun, DeLorey, Jennifer L, Centrella, Paolo A, Mataruse, Sibongile, Skinner, Steven R, Clark, Matthew A, Cuozzo, John W, Evindar, Ghotas

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Diastereoselective and Enantioselective Synthesis of Homopropargyl and Allenylcarbinols from Nonracemic Propargyl Mesylates via the Derived Allenyl and Propargyl Trichlorosilanes von Marshall, James A, Adams, Nicholas D

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Novel ATP-Competitive Kinesin Spindle Protein Inhibitors von Parrish, Cynthia A, Adams, Nicholas D, Auger, Kurt R, Burgess, Joelle L, Carson, Jeffrey D, Chaudhari, Amita M, Copeland, Robert A, Diamond, Melody A, Donatelli, Carla A, Duffy, Kevin J, Faucette, Leo F, Finer, Jeffrey T, Huffman, William F, Hugger, Erin D, Jackson, Jeffrey R, Knight, Steven D, Luo, Lusong, Moore, Michael L, Newlander, Ken A, Ridgers, Lance H, Sakowicz, Roman, Shaw, Antony N, Sung, Chiu-Mei M, Sutton, David, Wood, Kenneth W, Zhang, Shu-Yun, Zimmerman, Michael N, Dhanak, Dashyant

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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295 von Qian, Xiangping, McDonald, Andrew, Zhou, Han-Jie, Adams, Nicholas D, Parrish, Cynthia A, Duffy, Kevin J, Fitch, Duke M, Tedesco, Rosanna, Ashcraft, Luke W, Yao, Bing, Jiang, Hong, Huang, Jennifer K, Marin, Melchor V, Aroyan, Carrie E, Wang, Jianchao, Ahmed, Seyed, Burgess, Joelle L, Chaudhari, Amita M, Donatelli, Carla A, Darcy, Michael G, Ridgers, Lance H, Newlander, Ken A, Schmidt, Stanley J, Chai, Deping, Colón, Mariela, Zimmerman, Michael N, Lad, Latesh, Sakowicz, Roman, Schauer, Stephen, Belmont, Lisa, Baliga, Ramesh, Pierce, Daniel W, Finer, Jeffrey T, Wang, Zhengping, Morgan, Bradley P, Morgans, David J, Auger, Kurt R, Sung, Chiu-Mei, Carson, Jeff D, Luo, Lusong, Hugger, Erin D, Copeland, Robert A, Sutton, David, Elliott, John D, Jackson, Jeffrey R, Wood, Kenneth W, Dhanak, Dashyant, Bergnes, Gustave, Knight, Steven D

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A novel synthesis of substituted 4H-pyrazolo[3,4-d]pyrimidin-4-ones von Adams, Nicholas D., Schmidt, Stanley J., Knight, Steven D., Dhanak, Dashyant

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Synthesis of Chiral Enantioenriched Homopropargylic Alcohols from Propargylic Mesylates via Chiral Allenylzinc Intermediates von Marshall, James A, Adams, Nicholas D

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Progress toward the Total Synthesis of Bafilomycin A1:  Stereoselective Synthesis of the C15−C25 Subunit by Additions of Nonracemic Allenylzinc Reagents to Aldehydes von Marshall, James A, Adams, Nicholas D

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Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) von Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn, Carson, Jeff D., Elkins, Patricia A., Diamond, Melody, Gardiner, Christine M., Garver, Eric, Luo, Lusong, Raha, Kaushik, Sung, Chiu-Mei, Tummino, Peter J., Auger, Kurt R., Dhanak, Dashyant

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Abstract A35: Cytosolic reductive carboxylation is required for mitochondrial redox homeostasis during anchorage-independent cell growth von Jiang, Lei, Shestov, Alexander, Terada, Lance S., Adams, Nicholas D., McCabe, Michael T., Pietrak, Beth, Schimidt, Stan J., Schwartz, Benjamin, DeBerardinis, Ralph J.

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New IDH1 mutant inhibitors for treatment of acute myeloid leukemiaf von Okoye-oka, Ujunwa C, Bartholdy, Boris, Cartier, Jessy, Gao, Enoch N, Pietrak, Beth, Rendina, Alan R, Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Kenneth J, Reif, Alexander J, Schmidt, Stanley J, Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Groy, Arthur, Narayanagari, Swathi-rao, Antony-debre, Iléana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Makishima, Hideki, Will, Britta, Concha, Nestor, Adams, Nicholas D, Schwartz, Benjamin, Mccabe, Michael T, Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich

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Abstract C38: Novel allosteric IDH1 mutant Inhibitors for differentiation therapy of acute myeloid leukemia von Okoye-Okafor, Ujunwa C., Bartholdy, Boris, Cartier, Jessy, Gao, Enoch, Pietrak, Beth, Rendina, Alan R., Rominger, Cynthia, Quinn, Chad, Smallwood, Angela, Wiggall, Ken, Reif, Alexander, Schmidt, Stan, Qi, Hongwei, Zhao, Huizhen, Joberty, Gerard, Faelth-Savitski, Maria, Bantscheff, Marcus, Drewes, Gerard, Duraiswami, Chaya, Brady, Pat, Narayanagari, Swathi-Rao, Antony-Debre, Ileana, Mitchell, Kelly, Wang, Heng Rui, Kao, Yun-Ruei, Christopeit, Maximilian, Carvajal, Luis, Barreyro, Laura, Paietta, Elisabeth, Will, Britta, Concha, Nestor, Adams, Nicholas D., Schwartz, Benjamin, McCabe, Michael T., Maciejewski, Jaroslav, Verma, Amit, Steidl, Ulrich

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