Crystallographic structure of a small molecule SIRT1 activator-enzyme complex von Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.

Volltext

Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription-Factor Inhibitor von Ng, Pui Yee, Tang, Yuchen, Knosp, Wendy M, Stadler, H. Scott, Shaw, Jared T

Volltext

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators von Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Yen E, Sook, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.

Volltext

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes von Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei

Volltext

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma von Devlin, Jennifer R, Hannan, Katherine M, Hein, Nadine, Cullinane, Carleen, Kusnadi, Eric, Ng, Pui Yee, George, Amee J, Shortt, Jake, Bywater, Megan J, Poortinga, Gretchen, Sanij, Elaine, Kang, Jian, Drygin, Denis, O'Brien, Sean, Johnstone, Ricky W, McArthur, Grant A, Hannan, Ross D, Pearson, Richard B

Volltext

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms von Yue, Lanzhu, Sharma, Vasundhara, Horvat, Nathan P., Akuffo, Afua A., Beatty, Matthew S., Murdun, Cem, Colin, Christelle, Billington, Julia M.R., Goodheart, William E., Sahakian, Eva, Zhang, Ling, Powers, John J., Amin, Narmin E., Lambert-Showers, Que T., Darville, Lancia N., Pinilla-Ibarz, Javier, Reuther, Gary W., Wright, Kenneth L., Conti, Chiara, Lee, Jennifer Y., Zheng, Xiaozhang, Ng, Pui Yee, Martin, Matthew W., Marshall, C. Gary, Koomen, John M., Levine, Ross L., Verma, Amit, Grimes, H. Leighton, Sotomayor, Eduardo M., Shao, Zonghong, Epling-Burnette, Pearlie K.

Volltext

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer von Chan, Joanna C, Hannan, Katherine M, Riddell, Kim, Ng, Pui Yee, Peck, Abigail, Lee, Rachel S, Hung, Sandy, Astle, Megan V, Bywater, Megan, Wall, Meaghan, Poortinga, Gretchen, Jastrzebski, Katarzyna, Sheppard, Karen E, Hemmings, Brian A, Hall, Michael N, Johnstone, Ricky W, McArthur, Grant A, Hannan, Ross D, Pearson, Richard B

Volltext

SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging von Blum, Charles A, Ellis, James L, Loh, Christine, Ng, Pui Yee, Perni, Robert B, Stein, Ross L

Volltext

Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators von Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B

Volltext

Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators von Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.

Volltext

Strained Silacycles in Organic Synthesis:  A New Reagent for the Enantioselective Allylation of Aldehydes von Kinnaird, James W. A, Ng, Pui Yee, Kubota, Katsumi, Wang, Xiaolun, Leighton, James L

Volltext

Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11 von Martin, Matthew W., Lee, Jennifer Y., Lancia, David R., Ng, Pui Yee, Han, Bingsong, Thomason, Jennifer R., Lynes, Maureen S., Marshall, C. Gary, Conti, Chiara, Collis, Alan, Morales, Monica Alvarez, Doshi, Kshama, Rudnitskaya, Aleksandra, Yao, Lili, Zheng, Xiaozhang

Volltext

Abstract P229: Pre-clinical evaluation of next-generation inhibitor targeting a wide spectrum of oncogenic BRAF dimers von Han, Yoon-Chi, Ng, Pui Yee, Schulz, Ryan, Yang, Shao Ning, Lelo, Alana, Shin, Luisa, O'Connor, Matthew, Jewett, Ivan, Ishiyama, Noboru, Romashko, Darlene, Thakur, Shalabh, Salomatov, Andrei, Smith, Sherri, Buck, Elizabeth, Roberts, Christopher, Lucas, Matthew, Lin, Tai-An

Volltext

Abstract A090: Preclinical efficacy of BDTX-4933, a brain-penetrant, orthosteric RAF inhibitor, targeting oncogenic RAF conformation shared by groups of BRAF and upstream driver mu... von Han, Yoon-Chi, Ng, Pui Yee, Ogawa, Luisa Shin, Yang, Shao Ning, Chen, Miao, Romashko, Darlene, Lin, Tai-An, Buck, Elizabeth

Volltext

Abstract 3415: Preclinical characterization of a brain penetrant RAF inhibitor, BDTX-4933, targeting oncogenic BRAF Class I/II/III and RAS mutations von Han, Yoon-Chi, Ng, Pui-Yee, Ogawa, Luisa Shin, Yang, Shao Ning, Chen, Miao, Ishiyama, Noboru, Lin, Tai-An, Buck, Elizabeth

Volltext

Cycloaddition Reactions of Imines with 3-Thiosuccinic Anhydrides:  Synthesis of the Tricyclic Core of Martinellic Acid von Ng, Pui Yee, Masse, Craig E, Shaw, Jared T

Volltext

Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms von Sharma, Vasundhara, Yue, Lanzhu, Horvat, Nathan P., Christodoulidou, Agni, Akuffo, Afua Adutwumwa, Beatty, Mathew, Murdun, Cem, Billington, Julia, Goodheart, William E, Sahakian, Eva, Zhang, Ling, Powers, John J., Amin, Narmin E., Lambert-Showers, Que T., Darville, Lancia, Pinilla Ibarz, Javier, Reuther, Gary W., Lee, Jennifer, Zheng, Xiaozhang, Yee Ng, Pui, Martin, Mathew W., Marshall, Gary C., Koomen, John M., Levine, Ross L., Verma, Amit, Grimes, H. Leighton, Sotomayor, Eduardo, Shao, Zonghong, Wright, Kenneth, Epling-Burnette, Pearlie K.

Volltext

Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription-Factor Inhibitor von Ng, Pui Yee, Tang, Yuchen, Knosp, Wendy M., Stadler, H. Scott, Shaw, Jared T.

Volltext

The Enantioselective Allylation and Crotylation of Sterically Hindered and Functionalized Aryl Ketones: Convenient Access to Unusual Tertiary Carbinol Structures von Burns, Noah Z., Hackman, Blaine M., Ng, Pui Yee, Powelson, Ian A., Leighton, James L.

Volltext

2-SPIRO-5- AND 6-HYDROXAMIC ACID INDANES AS HDAC INHIBITORS von Zablocki, Mary-Margaret, Ng, Pui Yee, Zheng, Xiaozhang

Volltext bestellen