Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas von MITA, Monica M, SPEAR, Matthew A, PILAT, Maryjo, LLOYD, G. Kenneth, NEUTEBOOM, Saskia T. C, CROPP, Gillian, ASHTON, Edward, LORUSSO, Patricia M, YEE, Lorrin K, MITA, Alain C, HEATH, Elisabeth I, PAPADOPOULOS, Kyriakos P, FEDERICO, Kristine C, REICH, Steven D, ROMERO, Ofelia, MALBURG, Lisa

Volltext

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor von Macherla, Venkat R, Mitchell, Scott S, Manam, Rama Rao, Reed, Katherine A, Chao, Ta-Hsiang, Nicholson, Benjamin, Deyanat-Yazdi, Gordafaried, Mai, Bao, Jensen, Paul R, Fenical, William F, Neuteboom, Saskia T. C, Lam, Kin S, Palladino, Michael A, Potts, Barbara C. M

Volltext

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides von Manam, Rama Rao, McArthur, Katherine A, Chao, Ta-Hsiang, Weiss, Jeffrey, Ali, Janid A, Palombella, Vito J, Groll, Michael, Lloyd, G. Kenneth, Palladino, Michael A, Neuteboom, Saskia T. C, Macherla, Venkat R, Potts, Barbara C. M

Volltext

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on... von Millward, Michael, Price, Timothy, Townsend, Amanda, Sweeney, Christopher, Spencer, Andrew, Sukumaran, Shawgi, Longenecker, Angie, Lee, Lonnie, Lay, Ana, Sharma, Girish, Gemmill, Robert M., Drabkin, Harry A., Lloyd, G. Kenneth, Neuteboom, Saskia T. C., McConkey, David J., Palladino, Michael A., Spear, Matthew A.

Volltext

Lajollamycin, a nitro-tetraene spiro-β-lactone-γ-lactam antibiotic from the marine actinomycete Streptomyces nodosus von Manam, R.R, Teisan, S, White, D.J, Nicholson, B, Grodberg, J, Neuteboom, S.T.C, Lam, K.S, Mosca, D.A, Lloyd, G.K, Potts, B.C.M

Volltext

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome von Reed, Katherine A, Manam, Rama Rao, Mitchell, Scott S, Xu, Jianlin, Teisan, Sy, Chao, Ta-Hsiang, Deyanat-Yazdi, Gordafaried, Neuteboom, Saskia T. C, Lam, Kin S, Potts, Barbara C. M

Volltext

Antiprotealide Is a Natural Product von Manam, Rama Rao, Macherla, Venkat R, Tsueng, Ginger, Dring, Chris W, Weiss, Jeffrey, Neuteboom, Saskia T. C, Lam, Kin S, Potts, Barbara C

Volltext

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products von Ahn, Kwang Seok, Sethi, Gautam, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Chaturvedi, Madan M., Palladino, Michael A., Younes, Anas, Aggarwal, Bharat B.

Volltext

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs von Obaidat, Amanda, Weiss, Jeffrey, Wahlgren, Brett, Manam, Rama R, Macherla, Venkat R, McArthur, Katherine, Chao, Ta-Hsiang, Palladino, Michael A, Lloyd, G Kenneth, Potts, Barbara C, Enna, Salvatore J, Neuteboom, Saskia T C, Hagenbuch, Bruno

Volltext

NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint von Dellinger, Ryan W, Karjian, Patricia L, Neuteboom, Saskia T. C

Volltext

Oncogenic Homeodomain Transcription Factor E2A-Pbx1 Activates a Novel WNT Gene in Pre-B Acute Lymphoblastoid Leukemia von McWhirter, J R, Neuteboom, S T, Wancewicz, E V, Monia, B P, Downing, J R, Murre, C

Volltext

Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011 von Boyer, Christopher R, Karjian, Patricia L, Wahl, Geoffrey M, Pegram, Mark, Neuteboom, Saskia TC

Volltext

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib von Chauhan, Dharminder, Catley, Laurence, Li, Guilan, Podar, Klaus, Hideshima, Teru, Velankar, Mugdha, Mitsiades, Constantine, Mitsiades, Nicolas, Yasui, Hiroshi, Letai, Anthony, Ovaa, Huib, Berkers, Celia, Nicholson, Benjamin, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Richardson, Paul, Palladino, Michael A., Anderson, Kenneth C.

Volltext

The Hexapeptide LFPWMR in Hoxb-8 is Required for Cooperative DNA Binding with Pbx1 and Pbx2 Proteins von Saskia T. C. Neuteboom, Lucy T. C. Peltenburg, van Dijk, Marc A., Murre, Cornelis

Volltext

NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model von CUSACK, James C, RONG LIU, LIJUN XIA, CHAO, Ta-Hsiang, PIEN, Christine, WEI NIU, PALOMBELLA, Vito J, NEUTEBOOM, Saskia T. C, PALLADINO, Michael A

Volltext

NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent von Nicholson, Benjamin, Lloyd, G Kenneth, Miller, Brian R, Palladino, Michael A, Kiso, Yoshiaki, Hayashi, Yoshio, Neuteboom, Saskia T.C

Volltext

Inhibition of Cell Growth by NB1011 Requires High Thymidylate Synthase Levels and Correlates with p53, p21, Bax, and GADD45 Induction von Neuteboom, Saskia T C, Karjian, Patricia L, Boyer, Christopher R, Beryt, Malgorzhata, Pegram, Mark, Wahl, Geoffrey M, Shepard, H Michael

Volltext

Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces n odosus von Manam, Rama Rao, Teisan, Sy, White, Donald J, Nicholson, Benjamin, Grodberg, Jennifer, Neuteboom, Saskia T. C, Lam, Kin S, Mosca, Deborah A, Lloyd, G. Kenneth, Potts, Barbara C. M

Volltext

Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins von Neuteboom, Saskia T. C., Murre, Cornelis

Volltext

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products von Ahn, Kwang Seok, Sethi, Gautam, Chao, Ta-Hsiang, Neuteboom, Saskia T C, Chaturvedi, Madan M, Palladino, Michael A, Younes, Anas, Aggarwal, Bharat B

Volltext