Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model von Spangenberg, Elizabeth, Severson, Paul L., Hohsfield, Lindsay A., Crapser, Joshua, Zhang, Jiazhong, Burton, Elizabeth A., Zhang, Ying, Spevak, Wayne, Lin, Jack, Phan, Nicole Y., Habets, Gaston, Rymar, Andrey, Tsang, Garson, Walters, Jason, Nespi, Marika, Singh, Parmveer, Broome, Stephanie, Ibrahim, Prabha, Zhang, Chao, Bollag, Gideon, West, Brian L., Green, Kim N.

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Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling von Tripathi, Rakshamani, Liu, Zulong, Jain, Aditi, Lyon, Anastasia, Meeks, Christina, Richards, Dana, Liu, Jinpeng, He, Daheng, Wang, Chi, Nespi, Marika, Rymar, Andrey, Wang, Peng, Wilson, Melissa, Plattner, Rina

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BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor von Ozer, Hatice Gulcin, El-Gamal, Dalia, Powell, Ben, Hing, Zachary A, Blachly, James S, Harrington, Bonnie, Mitchell, Shaneice, Grieselhuber, Nicole R, Williams, Katie, Lai, Tzung-Huei, Alinari, Lapo, Baiocchi, Robert A, Brinton, Lindsey, Baskin, Elizabeth, Cannon, Matthew, Beaver, Larry, Goettl, Virginia M, Lucas, David M, Woyach, Jennifer A, Sampath, Deepa, Lehman, Amy M, Yu, Lianbo, Zhang, Jiazhong, Ma, Yan, Zhang, Ying, Spevak, Wayne, Shi, Songyuan, Severson, Paul, Shellooe, Rafe, Carias, Heidi, Tsang, Garson, Dong, Ken, Ewing, Todd, Marimuthu, Adhirai, Tantoy, Christina, Walters, Jason, Sanftner, Laura, Rezaei, Hamid, Nespi, Marika, Matusow, Bernice, Habets, Gaston, Ibrahim, Prabha, Zhang, Chao, Mathé, Ewy A, Bollag, Gideon, Byrd, John C, Lapalombella, Rosa

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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor von Zhang, Chao, Ibrahim, Prabha N., Zhang, Jiazhong, Burton, Elizabeth A., Habets, Gaston, Zhang, Ying, Powell, Ben, West, Brian L., Matusow, Bernice, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Nguyen, Hoa, Marimuthu, Adhirai, Zhang, Kam Y. J., Oh, Angela, Bremer, Ryan, Hurt, Clarence R., Artis, Dean R., Wu, Guoxian, Nespi, Marika, Spevak, Wayne, Lin, Paul, Nolop, Keith, Hirth, Peter, Tesch, Greg H., Bollag, Gideon

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Vehicle effect on in-vitro and in-vivo performance of spray-dried dispersions von Nespi, Marika, Ly, Justin, Fan, Yuchen, Chen, Shu, Liu, Liling, Gu, Yimin, Castleberry, Steven

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RAF inhibitors that evade paradoxical MAPK pathway activation von Zhang, Chao, Spevak, Wayne, Zhang, Ying, Burton, Elizabeth A., Ma, Yan, Habets, Gaston, Zhang, Jiazhong, Lin, Jack, Ewing, Todd, Matusow, Bernice, Tsang, Garson, Marimuthu, Adhirai, Cho, Hanna, Wu, Guoxian, Wang, Weiru, Fong, Daniel, Nguyen, Hoa, Shi, Songyuan, Womack, Patrick, Nespi, Marika, Shellooe, Rafe, Carias, Heidi, Powell, Ben, Light, Emily, Sanftner, Laura, Walters, Jason, Tsai, James, West, Brian L., Visor, Gary, Rezaei, Hamid, Lin, Paul S., Nolop, Keith, Ibrahim, Prabha N., Hirth, Peter, Bollag, Gideon

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Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide... von McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.

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Optimization of Spray-Drying Parameters for Formulation Development at Preclinical Scale von Nespi, Marika, Kuhn, Robert, Yen, Chun-Wan, Lubach, Joseph W., Leung, Dennis

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Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-s... von McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.

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PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors von Gebreyohannes, Yemarshet K., Burton, Elizabeth A., Wozniak, Agnieszka, Matusow, Bernice, Habets, Gaston, Wellens, Jasmien, Cornillie, Jasmien, Lin, Jack, Nespi, Marika, Wu, Guoxian, Zhang, Chao, Bollag, Gideon, Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick

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Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2) von Zeng, Mingshuo, Grandner, Jessica M., Bryan, Marian C., Verma, Vishal, Larouche-Gauthier, Robin, Leclerc, Jean-Philippe, Zhao, Liang, Haghshenas, Pouyan, Aubert-Nicol, Samuel, Yadav, Arun, Ashley, Melissa, Chen, Jacob Z., Durk, Matthew, Samy, Karen E., Nespi, Marika, Levy, Elizabeth, Merrick, Karl, Moffat, John G., Murray, Jeremy, Oh, Angela, Orr, Christine, Segal, Ehud, Sims, Jessica, Sneeringer, Christopher, Prangley, Madeleine, Vartanian, Steffan, Magnuson, Steven, Parr, Brendan T.

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PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors von Gebreyohannes, Yemarshet K, Burton, Elizabeth A, Wozniak, Agnieszka, Matusow, Bernice, Habets, Gaston, Wellens, Jasmien, Cornillie, Jasmien, Lin, Jack, Nespi, Marika, Wu, Guoxian, Zhang, Chao, Bollag, Gideon, Debiec-Rychter, Maria, Sciot, Raf, Schoffski, Patrick

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Total synthesis of both enantiomers of trans-2,3- cis-3,4-dihydroxyproline von Zanardi, Franca, Battistini, Lucia, Nespi, Marika, Rassu, Gloria, Spanu, Pietro, Cornia, Mara, Casiraghi, Giovanni

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Abstract A229: BRAF inhibitors upregulate EGFR ligands: A molecular link to RAF inhibitor-induced cutaneous squamous cell carcinomas von Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A., Wong, Bernice, Nguyen, Hoa, Spevak, Wayne, zhang, Jiazhong, Cho, Hanna, Wu, Guoxian, Lin, Jack L., Ewing, Todd, Zhang, Ying, Shi, Songyuan, Nespi, Marika, Tsang, Garson, Marimuthu, Adhirai, Light, Emily, Powell, Ben, Shellooe, Rafe, Tsai, James, West, Brian L., Ibrahim, Prabha N., Hirth, Peter, Bollag, Gideon

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Formulations of a compound modulating kinases von NESPI, Marika, REZAEI, Hamid, IBRAHIM, Prabha N, VISOR, Gary Conard

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FORMULATIONS OF A COMPOUND MODULATING KINASES von NESPI, Marika, REZAEI, Hamid, IBRAHIM, Prabha N, VISOR, Gary Conard

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FORMULATIONS OF A COMPOUND MODULATING KINASES von VISOR, GARY CONARD, NESPI, MARIKA, REZAEI, HAMID, IBRAHIM, PRABHA N

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FORMULATIONS OF A COMPOUND MODULATING KINASES von Nespi, Marika, Ibrahim, Prabha N, Rezaei, Hamid, Visor, Gary Conard

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Crystalline forms of a compound that inhibits bromodomain von Nespi, Marika, Lin, Jack, Walters, Jason

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CRYSTALLINE FORMS OF 4-(1-(1,1-DI(PYRIDIN-2-YL)ETHYL)-6-(3,5-DIMETHYLISOXAZOL-4-YL)-1H- PYRROLO[3,2-B]PYRIDIN-3-YL)BENZOIC ACID THAT INHIBITS BROMODOMAIN von NESPI, Marika, LIN, Jack, WALTERS, Jason

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