Mechanism-Based Inactivation of Cytochrome P450 3A4 by Lapatinib von Teng, Woon Chien, Oh, Jing Wen, New, Lee Sun, Wahlin, Michelle D., Nelson, Sidney D., Ho, Han Kiat, Chan, Eric Chun Yong

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High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry von Wen, Bo, Ma, Li, Nelson, Sidney D, Zhu, Mingshe

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Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer von Kyriakides, Michael, Maitre, Lea, Stamper, Brendan D., Mohar, Isaac, Kavanagh, Terrance J., Foster, John, Wilson, Ian D., Holmes, Elaine, Nelson, Sidney D., Coen, Muireann

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An Inducible Cytochrome P450 3A4-Dependent Vitamin D Catabolic Pathway von Wang, Zhican, Lin, Yvonne S., Zheng, Xi Emily, Senn, Tauri, Hashizume, Takanori, Scian, Michele, Dickmann, Leslie J., Nelson, Sidney D., Baillie, Thomas A., Hebert, Mary F., Blough, David, Davis, Connie L., Thummel, Kenneth E.

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The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4 von Roberts, Arthur G, Yang, Jing, Halpert, James R, Nelson, Sidney D, Thummel, Kenneth T, Atkins, William M

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Rearrangement reactions catalyzed by cytochrome P450s von Ortiz de Montellano, Paul R., Nelson, Sidney D.

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Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib von Takakusa, Hideo, Wahlin, Michelle D., Zhao, Chunsheng, Hanson, Kelsey L., New, Lee Sun, Chan, Eric Chun Yong, Nelson, Sidney D.

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Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6 von Mohar, Isaac, Stamper, Brendan D, Rademacher, Peter M, White, Collin C, Nelson, Sidney D, Kavanagh, Terrance J

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Metabolism and Toxicity of Menthofuran in Rat Liver Slices and in Rats von Khojasteh, S. Cyrus, Oishi, Shimako, Nelson, Sidney D

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Proteomic Analysis of Acetaminophen-Induced Changes in Mitochondrial Protein Expression Using Spectral Counting von Stamper, Brendan D, Mohar, Isaac, Kavanagh, Terrance J, Nelson, Sidney D

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Inhibition of Macrophage Migration Inhibitory Factor (MIF) Tautomerase and Biological Activities by Acetaminophen Metabolites von Senter, Peter D., Al-Abed, Yousef, Metz, Christine N., Benigni, Fabio, Mitchell, Robert A., Chesney, J., Han, Jianlin, Gartner, Carlos G., Nelson, Sidney D., Todaro, George J., Bucala, Richard

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Identification of the Interactions between Cytochrome P450 2E1 and Cytochrome b5 by Mass Spectrometry and Site-directed Mutagenesis von Gao, Qiuxia, Doneanu, Catalin E., Shaffer, Scott A., Adman, Elinor T., Goodlett, David R., Nelson, Sidney D.

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Cooperative Binding of Acetaminophen and Caffeine within the P450 3A4 Active Site von Cameron, Michael D, Wen, Bo, Roberts, Arthur G, Atkins, William M, Patricia Campbell, A, Nelson, Sidney D

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Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells von Hardy, Klarissa D, Wahlin, Michelle D, Papageorgiou, Ioannis, Unadkat, Jashvant D, Rettie, Allan E, Nelson, Sidney D

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Nrf2 Activation Involves an Oxidative-Stress Independent Pathway in Tetrafluoroethylcysteine-Induced Cytotoxicity von Ho, Han K., White, Collin C., Fernandez, Carolina, Fausto, Nelson, Kavanagh, Terrance J., Nelson, Sidney D., Bruschi, Sam A.

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p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo von Stamper, Brendan D., Garcia, Michael L., Nguyen, Duy Q., Beyer, Richard P., Bammler, Theo K., Farin, Frederico M., Kavanagh, Terrance J., Nelson, Sidney D.

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Oxidation of Acetaminophen to Its Toxic Quinone Imine and Nontoxic Catechol Metabolites by Baculovirus-Expressed and Purified Human Cytochromes P450 2E1 and 2A6 von Chen, Weiqiao, Koenigs, Luke L, Thompson, Stella J, Peter, Raimund M, Rettie, Allan E, Trager, William F, Nelson, Sidney D

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Differential Oxidation of Two Thiophene-Containing Regioisomers to Reactive Metabolites by Cytochrome P450 2C9 von Rademacher, Peter M, Woods, Caleb M, Huang, Qingbiao, Szklarz, Grazyna D, Nelson, Sidney D

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Interaction of Lapatinib with Cytochrome P450 3A5 von Chan, Eric Chun Yong, New, Lee Sun, Chua, Teck Beng, Yap, Chun Wei, Ho, Han Kiat, Nelson, Sidney D.

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Fluorescent Photoaffinity Labeling of Cytochrome P450 3A4 by Lapachenole:  Identification of Modification Sites by Mass Spectrometry von Wen, Bo, Doneanu, Catalin E., Gartner, Carlos A., Roberts, Arthur G., Atkins, William M., Nelson, Sidney D.

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