2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition von Banerjee, Soojay, Bartesaghi, Alberto, Merk, Alan, Rao, Prashant, Bulfer, Stacie L., Yan, Yongzhao, Green, Neal, Mroczkowski, Barbara, Neitz, R. Jeffrey, Wipf, Peter, Falconieri, Veronica, Deshaies, Raymond J., Milne, Jacqueline L. S., Huryn, Donna, Arkin, Michelle, Subramaniam, Sriram

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Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments von Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.

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Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2 von Gahbauer, Stefan, Correy, Galen J, Schuller, Marion, Ferla, Matteo P, Doruk, Yagmur Umay, Rachman, Moira, Wu, Taiasean, Diolaiti, Morgan, Wang, Siyi, Neitz, R Jeffrey, Fearon, Daren, Radchenko, Dmytro S, Moroz, Yurii S, Irwin, John J, Renslo, Adam R, Taylor, Jenny C, Gestwicki, Jason E, von Delft, Frank, Ashworth, Alan, Ahel, Ivan, Shoichet, Brian K, Fraser, James S

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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease von Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek

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Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni von Long, Thavy, Neitz, R Jeffrey, Beasley, Rachel, Kalyanaraman, Chakrapani, Suzuki, Brian M, Jacobson, Matthew P, Dissous, Colette, McKerrow, James H, Drewry, David H, Zuercher, William J, Singh, Rahul, Caffrey, Conor R

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From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking von Visser, Emira J., Jaishankar, Priyadarshini, Sijbesma, Eline, Pennings, Marloes A. M., Vandenboorn, Edmee M. F., Guillory, Xavier, Neitz, R. Jeffrey, Morrow, John, Dutta, Shubhankar, Renslo, Adam R., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian

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Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease von Neitz, R. Jeffrey, Chen, Steven, Supek, Frantisek, Yeh, Vince, Kellar, Danielle, Gut, Jiri, Bryant, Clifford, Gallardo-Godoy, Alejandra, Molteni, Valentina, Roach, Steven L., Chatterjee, Arnab K., Robertson, Stephanie, Renslo, Adam R., Arkin, Michelle, Glynne, Richard, McKerrow, James, Siqueira-Neto, Jair L.

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Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones von SHENAI, Bhaskar R, LEE, Belinda J, ALVAREZ-HERNANDEZ, Alejandro, CHONG, Pek Y, EMAL, Cory D, NEITZ, R. Jeffrey, ROUSH, William R, ROSENTHAL, Philip J

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A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers von Kenanova, Dyana N., Visser, Emira J., Virta, Johanna M., Sijbesma, Eline, Centorrino, Federica, Vickery, Holly R., Zhong, Mengqi, Neitz, R. Jeffrey, Brunsveld, Luc, Ottmann, Christian, Arkin, Michelle R.

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Structure–Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 von Alverez, Celeste, Arkin, Michelle R, Bulfer, Stacie L, Colombo, Raffaele, Kovaliov, Marina, LaPorte, Matthew G, Lim, Chaemin, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Yan, Yongzhao, Yue, Zhizhou, Huryn, Donna M, Wipf, Peter

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Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease von Neitz, R. Jeffrey, Bryant, Clifford, Chen, Steven, Gut, Jiri, Hugo Caselli, Estefania, Ponce, Servando, Chowdhury, Somenath, Xu, Haichao, Arkin, Michelle R., Ellman, Jonathan A., Renslo, Adam R.

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TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling von Wolfe, Alan R., Neitz, R. Jeffrey, Burlingame, Mark, Suzuki, Brian M., Lim, KC, Scheideler, Mark, Nelson, David L., Benet, Leslie Z., Caffrey, Conor R.

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Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97 von LaPorte, Matthew G, Burnett, James C, Colombo, Raffaele, Bulfer, Stacie L, Alverez, Celeste, Chou, Tsui-Fen, Neitz, R. Jeffrey, Green, Neal, Moore, William J, Yue, Zhizhou, Li, Shan, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M

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Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening von Ortiz, Gloria, Longbotham, James E, Qin, Sophia L, Zhang, Meng Yao, Lee, Gregory M, Neitz, R. Jeffrey, Kelly, Mark J. S, Arkin, Michelle R, Fujimori, Danica Galoni

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration von Bowers, Simeon, Truong, Anh P., Jeffrey Neitz, R., Hom, Roy K., Sealy, Jennifer M., Probst, Gary D., Quincy, David, Peterson, Brian, Chan, Wayman, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Lin, May, Yao, Nanhua, Artis, Dean R., Zhang, Heather, Chen, Linda, Dryer, Mark, Samant, Bhushan, Zmolek, Wes, Wong, Karina, Lorentzen, Colin, Goldbach, Erich, Tonn, George, Quinn, Kevin P., Sauer, John-Michael, Wright, Sarah, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking von Visser, Emira J., Jaishankar, Priyadarshini, Sijbesma, Eline, Pennings, Marloes A. M., Vandenboorn, Edmee M. F., Guillory, Xavier, Neitz, R. Jeffrey, Morrow, John, Dutta, Shubhankar, Renslo, Adam R., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian

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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway von Alverez, Celeste, Bulfer, Stacie L, Chakrasali, Ramappa, Chimenti, Michael. S, Deshaies, Raymond J, Green, Neal, Kelly, Mark, LaPorte, Matthew G, Lewis, Taber S, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Peshkov, Vsevolod A, Walters, Michael A, Zhang, Feng, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor von Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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Novel cinnoline-based inhibitors of LRRK2 kinase activity von Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Bowers, Simeon, Franzini, Maurizio, Goldbach, Erich, Lorentzen, Colin, Neitz, R. Jeffrey, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors von Bowers, Simeon, Truong, Anh P., Ye, Michael, Aubele, Danielle L., Sealy, Jennifer M., Neitz, R. Jeffrey, Hom, Roy K., Chan, Wayman, Dappen, Michael S., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Tonn, George, Zhang, Heather, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Pandya, Deepal, Diep, Linnea, Fitzgerald, Kent, Artis, Dean R., Anderson, John P., Bergeron, Marcelle

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